Advances in structure-based drug design targeting membrane protein markers in prostate cancer.

Autor: Batista-Silva JP; CICS-UBI-Health Sciences Research Centre, University of Beira Interior, 6201-506 Covilhã, Portugal; UCIBIO-Applied Molecular Biosciences Unit, Chemistry Department, NOVA School of Science and Technology, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal; Associate Laboratory i4HB-Institute for Health and Bioeconomy, NOVA School of Science and Technology, Universidade NOVA de Lisboa, 2819-516 Caparica, Portugal., Gomes D; CICS-UBI-Health Sciences Research Centre, University of Beira Interior, 6201-506 Covilhã, Portugal; UCIBIO-Applied Molecular Biosciences Unit, Chemistry Department, NOVA School of Science and Technology, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal; Associate Laboratory i4HB-Institute for Health and Bioeconomy, NOVA School of Science and Technology, Universidade NOVA de Lisboa, 2819-516 Caparica, Portugal., Sousa SF; LAQV/REQUIMTE, BioSIM - Department of Medicine, Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal., Sousa Â; CICS-UBI-Health Sciences Research Centre, University of Beira Interior, 6201-506 Covilhã, Portugal. Electronic address: angela@fcsaude.ubi.pt., Passarinha LA; CICS-UBI-Health Sciences Research Centre, University of Beira Interior, 6201-506 Covilhã, Portugal; UCIBIO-Applied Molecular Biosciences Unit, Chemistry Department, NOVA School of Science and Technology, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal; Associate Laboratory i4HB-Institute for Health and Bioeconomy, NOVA School of Science and Technology, Universidade NOVA de Lisboa, 2819-516 Caparica, Portugal; Laboratório de Fármaco-Toxicologia-UBIMedical, University of Beira Interior, 6200-284 Covilhã, Portugal. Electronic address: lpassarinha@fcsaude.ubi.pt.

Publikováno v: Drug discovery today [Drug Discov Today] 2024 Sep; Vol. 29 (9), pp. 104130. Date of Electronic Publication: 2024 Aug 03.

Scaffold hopping approaches for dual-target antitumor drug discovery: opportunities and challenges.

Autor: Mishra A; School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan., Thakur A; School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan., Sharma R; School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan., Onuku R; Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA., Kaur C; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, India., Liou JP; School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan.; Program in Drug Discovery and Development Industry, College of Pharmacy, Taipei Medical University, Taiwan., Hsu SP; Department of Physiology, School of Medicine, College of Medicine, Taipei Medical University, Taiwan., Nepali K; School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan.; Program in Drug Discovery and Development Industry, College of Pharmacy, Taipei Medical University, Taiwan.

Publikováno v: Expert opinion on drug discovery [Expert Opin Drug Discov] 2024 Nov; Vol. 19 (11), pp. 1355-1381. Date of Electronic Publication: 2024 Oct 17.

Design and Synthesis of Potential Multi-Target Antidepressants: Exploration of 1-(4-(7-Azaindole)-3,6-dihydropyridin-1-yl)alkyl-3-(1 H -indol-3-yl)pyrrolidine-2,5-dione Derivatives with Affinity for the Serotonin Transporter.

Autor: Wróbel MZ; Department of Drug Technology and Pharmaceutical Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Street, 02-097 Warszawa, Poland., Chodkowski A; Department of Drug Technology and Pharmaceutical Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Street, 02-097 Warszawa, Poland., Siwek A; Department of Pharmacobiology, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Kraków, Poland., Satała G; Department of Medicinal Chemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31-343 Kraków, Poland., Bojarski AJ; Department of Medicinal Chemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31-343 Kraków, Poland., Dawidowski M; Department of Drug Technology and Pharmaceutical Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Street, 02-097 Warszawa, Poland.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2024 Oct 20; Vol. 25 (20). Date of Electronic Publication: 2024 Oct 20.

Unraveling the future: Innovative design strategies and emerging challenges in HER2-targeted tyrosine kinase inhibitors for cancer therapy.

Autor: Zheng S; Department of Clinical Research, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, 610041, China., Chen R; Department of Breast Center, West China Hospital, Sichuan University, Chengdu, 610041, China., Zhang L; Department of Respiratory and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, Institute of Respiratory Health, Frontiers Science Center for Disease-related Molecular Network, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China., Tan L; Department of Respiratory and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, Institute of Respiratory Health, Frontiers Science Center for Disease-related Molecular Network, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China., Li L; Department of Radiotherapy, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, 610041, China. Electronic address: lilintao@scszlyy.org.cn., Long F; Laboratory Medicine Center, Sichuan Provincial Maternity and Child Health Care Hospital, Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu Medical College, Chengdu, 610032, China. Electronic address: Longfangyi1206@163.com., Wang T; Department of Clinical Research, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, 610041, China. Electronic address: wangting8934@126.com.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2024 Oct 05; Vol. 276, pp. 116702. Date of Electronic Publication: 2024 Jul 23.

Uncovering the antidiabetic potential of heart-friendly and diuretic bioactive compounds through computer-based drug design.

Autor: Ercin N; Department of Medical Biology, Hamidiye School of Medicine, University of Health Sciences, Istanbul, Turkey. Electronic address: nlfrbilgic@gmail.com., Besli N; Department of Medical Biology, Hamidiye School of Medicine, University of Health Sciences, Istanbul, Turkey. Electronic address: beslinail@gmail.com., Kilic U; Department of Medical Biology, Hamidiye School of Medicine, University of Health Sciences, Istanbul, Turkey; Department of Medical Biology, Institute of Health Sciences, University of Health Sciences, Istanbul, Turkey. Electronic address: uckilic@yahoo.com.

Publikováno v: Computational biology and chemistry [Comput Biol Chem] 2024 Oct; Vol. 112, pp. 108180. Date of Electronic Publication: 2024 Aug 18.