Zobrazeno 1 - 10
of 102
pro vyhledávání: '"drug delivery and targeting"'
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/3358d1f849bb4242a31af2eb235eb86f
Autor:
D. Parajuli
Publikováno v:
Frontiers in Chemistry, Vol 12 (2024)
The article discusses the promising synergy between MXenes and polymers in developing advanced nanocomposites with diverse applications in biomedicine domains. MXenes, possessing exceptional properties, are integrated into polymer matrices through va
Externí odkaz:
https://doaj.org/article/e26c9214fccc4f3ab1b36e790c02aaf6
Autor:
Junpei Takahashi, Yudai Ueta, Daisuke Yamada, Sachie Sasaki‐Hamada, Takashi Iwai, Tomomi Akita, Chikamasa Yamashita, Akiyoshi Saitoh, Jun‐Ichiro Oka
Publikováno v:
Neuropsychopharmacology Reports, Vol 42, Iss 4, Pp 492-501 (2022)
Abstract Aim We previously reported that oxytocin, a peptide hormone, can reverse the β‐amyloid peptide (25–35) (Aβ25–35)‐induced impairments of the murine hippocampal synaptic plasticity. In this study, we examined the effects of oxytocin
Externí odkaz:
https://doaj.org/article/ff4dd2c485744413a1596cf3f380bc36
Autor:
Ye-Wei Yang, Nian-Hua Deng, Kai-Jiang Tian, Lu-Shan Liu, Zuo Wang, Dang-Heng Wei, Hui-Ting Liu, Zhi-Sheng Jiang
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Hydrogen sulfide (H2S), a gas transmitter found in eukaryotic organisms, plays an essential role in several physiological processes. H2S is one of the three primary biological gas transmission signaling mediators, along with nitric oxide and carbon m
Externí odkaz:
https://doaj.org/article/b85ca2d0a4204be79575c59e9efa40af
Publikováno v:
Al-Mustansiriyah Journal of Pharmaceutical Sciences, Vol 21, Iss 2 (2022)
Polymeric micelles are nanoscale core-shell structures formed by amphiphilic (block or graft) copolymers, that can self-aggregate in an aqueous medium. PMs characterized by small size, spherical shape, lower critical micellar concentration, which gav
Externí odkaz:
https://doaj.org/article/56fe3fe7ac9347a6a827e00987bf2cd2
Autor:
Nicholas J. Hunt, Peter A. G. McCourt, Zdenka Kuncic, David G. Le Couteur, Victoria C. Cogger
Publikováno v:
Frontiers in Nanotechnology, Vol 4 (2022)
Nanotherapeutics utilize the properties of nanomaterials to alter the pharmacology of the drugs and therapies being transported, leading to changes in their biological disposition (absorption, distribution, cellular uptake, metabolism and elimination
Externí odkaz:
https://doaj.org/article/c722c246b3e84f3eaf91e28120394986
Autor:
Patrizia Colucci, Martina Giannaccini, Matteo Baggiani, Breandán N. Kennedy, Luciana Dente, Vittoria Raffa, Chiara Gabellini
Publikováno v:
Pharmaceutics, Vol 15, Iss 4, p 1096 (2023)
Neuroprotective drug delivery to the posterior segment of the eye represents a major challenge to counteract vision loss. This work focuses on the development of a polymer-based nanocarrier, specifically designed for targeting the posterior eye. Poly
Externí odkaz:
https://doaj.org/article/9e283d5e21a04d8885aed0d715cd42b2
Autor:
Hendrik Schneider, Simon Englert, Arturo Macarrón Palacios, Jorge Alberto Lerma Romero, Ataurehman Ali, Olga Avrutina, Harald Kolmar
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
Herein, we present the design, synthesis, and biological evaluation of novel integrin-targeting molecular hybrids combining RGD peptides and a potent cytotoxin presented on dextran polysaccharides. Based on an aglycosylated Fc as a centerpiece, endos
Externí odkaz:
https://doaj.org/article/7457a920b2374692ac7c334e6ac165cf
Autor:
Chaahat S. B. Singh, Brett A. Eyford, Thomas Abraham, Lonna Munro, Kyung Bok Choi, Mark Okon, Timothy Z. Vitalis, Reinhard Gabathuler, Chieh-Ju Lu, Cheryl G. Pfeifer, Mei Mei Tian, Wilfred A. Jefferies
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
The blood-brain barrier (BBB) hinders the distribution of therapeutics intended for treatment of diseases of the brain. Our previous studies demonstrated that that a soluble form of melanotransferrin (MTf; Uniprot P08582; also known as p97, MFI2, and
Externí odkaz:
https://doaj.org/article/288f8666a28c48d19137c9e3c081e799
Autor:
Shiqi Wang
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
The intracellular delivery of emerging biomacromolecular therapeutics, such as genes, peptides, and proteins, remains a great challenge. Unlike small hydrophobic drugs, these biotherapeutics are impermeable to the cell membrane, thus relying on the e
Externí odkaz:
https://doaj.org/article/79a0c2a45e054fe7818cc674e3cade05