Zobrazeno 1 - 10
of 1 592
pro vyhledávání: '"drug candidate"'
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 9, Pp 4189-4192 (2024)
Externí odkaz:
https://doaj.org/article/12464dbf511143de968887e923a534db
Autor:
Jinming Zhang, Yixin Li, Liu Yang, Ningning Ma, Shengying Qian, Yingfen Chen, Yajun Duan, Xiaogang Xiang, Yong He
Publikováno v:
Cell & Bioscience, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Metabolic disorders are currently threatening public health worldwide. Discovering new targets and developing promising drugs will reduce the global metabolic-related disease burden. Metabolic disorders primarily consist of lipid and glucose
Externí odkaz:
https://doaj.org/article/2a4e3c43fd9f4123a4465768d3316b0f
Autor:
Yanying Sun, Zhenzhen Zhou, Zhongling Shi, Fabao Zhao, Minghui Xie, Zongji Zhuo, Erik De Clercq, Christophe Pannecouque, Dongwei Kang, Peng Zhan, Xinyong Liu
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 7, Pp 3110-3124 (2024)
HIV-1 reverse transcriptase (RT) has received great attention as an attractive therapeutic target for acquired immune deficiency syndrome (AIDS), but the inevitable drug resistance and side effects have always been major challenges faced by non-nucle
Externí odkaz:
https://doaj.org/article/11cdd506ac7a43449abb83e409f2a953
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Hepatocellular carcinoma (HCC) is one of the most significant causes of cancer-related deaths in the worldwide. Currently, predicting the survival of patients with HCC and developing treatment drugs still remain a significant challenge. In t
Externí odkaz:
https://doaj.org/article/e170550f8f904564a1b53b45a69abe85
Autor:
Md. Minhazul Abedin, Tarun Kumar Pal, Md. Najem Uddin, Mohammad Abdul Alim, Md. Chanmiya Sheikh, Subrata Paul
Publikováno v:
Heliyon, Vol 10, Iss 14, Pp e34556- (2024)
The sulfonamide Schiff base compound (E)-4-((4-(dimethylamino)benzylidene)amino)-N-(5-methylisoxazol-3-yl)benzenesulfonamide was successfully prepared and fully characterized. The foremost objective of this study was to explore the molecular geometry
Externí odkaz:
https://doaj.org/article/3857d63b0db34d6b9495a052ae84fce0
Autor:
Ahmad Misbakhus Sururi, Dwi Anggorowati Rahayu, Martina Kurnia Rohma, Maftukhatul Faizah, Elsa Aulia Vebianawati, Mia Savita
Publikováno v:
Future Journal of Pharmaceutical Sciences, Vol 9, Iss 1, Pp 1-8 (2023)
Abstract Background Carcinoscorpius rotundicauda is a species of horseshoe crab that is rarely studied. This animal is often used as part of the blood as a medical sterilization material. This study aims to identify the content of bioactive compounds
Externí odkaz:
https://doaj.org/article/c120f6e0d5e2449299bacb7630a3f502
Autor:
Hüseyin Oğuzhan Kaya, Gokay Albayrak, Hasan Isbilir, Fatma Kurul, Sura Baykan, Yeni Wahyuni Hartati, Seda Nur Topkaya
Publikováno v:
ADMET and DMPK (2024)
Background and purpose: In this study, we present an electrochemical sensor for the detection of oxypeucedanin (Oxyp) and prantschimgin (Pra), two natural furanocoumarin derivatives. The determination of the effects of these molecules on DNA is impor
Externí odkaz:
https://doaj.org/article/ab839316db04430a8c7b00bcc791ca19
Autor:
Bo Jin, Xuechao Pang, Qingce Zang, Man Ga, Jing Xu, Zhigang Luo, Ruiping Zhang, Jiangong Shi, Jiuming He, Zeper Abliz
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 4, Pp 1699-1710 (2023)
Deconvolution of potential drug targets of the central nervous system (CNS) is particularly challenging because of the complicated structure and function of the brain. Here, a spatiotemporally resolved metabolomics and isotope tracing strategy was pr
Externí odkaz:
https://doaj.org/article/9de02e4a0e7b4044a94de686097a0b78
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Akademický článek
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