Zobrazeno 1 - 10
of 3 972
pro vyhledávání: '"drp1"'
Autor:
Dongyao Hou, Ruixue Liu, Shuai Hao, Yong Dou, Guizhen Chen, Liangming Liu, Tao Li, Yunxing Cao, He Huang, Chenyang Duan
Publikováno v:
Pharmaceutical Biology, Vol 62, Iss 1, Pp 250-260 (2024)
Context Sepsis can result in critical organ failure, and notoginsenoside R1 (NGR1) offers mitochondrial protection.Objective To determine whether NGR1 improves organ function and prognosis after sepsis by protecting mitochondrial quality.Materials an
Externí odkaz:
https://doaj.org/article/19166c5812f24bd089ae13a55298d8aa
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract This study investigated the role of mitochondrial dynamics in postoperative cognitive dysfunction (POCD) and assessed the therapeutic potential of mitochondrial modulation, particularly through the inhibition of dynamin-related protein 1 (DR
Externí odkaz:
https://doaj.org/article/4ba713ee0432430d9f6cad8f7bb11920
Autor:
Jiejie Zhang, Shan Wang, Haitao Zhang, Xiaotong Yang, Xin Ren, Lei Wang, Yihan Yang, Yi Yang, Ya Wen
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-19 (2024)
Abstract The aberrant acetylation of mitochondrial proteins is involved in the pathogenesis of multiple diseases including neurodegenerative diseases and cerebral ischemic injury. Previous studies have shown that depletion of mitochondrial NAD+, whic
Externí odkaz:
https://doaj.org/article/51b25f8766ba48aaa422fc9672ae9deb
Autor:
Yong Du, Jiaqing He, Yanni Xu, Xun Wu, Hongbo Cheng, Jiegang Yu, Xiaoliang Wang, Yaqing An, Yang Wu, Wei Guo
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Vascular dementia (VaD) is a prevalent form of dementia resulting from chronic cerebral hypoperfusion (CCH). However, the pathogenic mechanisms of VaD and corresponding therapeutic strategies are not well understood. Sirtuin 6 (SIRT6) has be
Externí odkaz:
https://doaj.org/article/668a3585517941d481c58d00047cc945
Autor:
Marvi Ghani, Bernadett Szabó, Mahmoud Alkhatibe, Hailemariam Amsalu, Peleg Zohar, Eszter Anna Janka, János András Mótyán, Krisztina Tar
Publikováno v:
FEBS Open Bio, Vol 14, Iss 7, Pp 1147-1165 (2024)
Continuous fusion and fission are critical for mitochondrial health. In this study, we further characterize the role played by dynamin‐related protein 1 (Drp1) in mitochondrial fission. We show that a single amino acid change in Drp1 at position 39
Externí odkaz:
https://doaj.org/article/19ffca4c0a7c41e2aa21802b52e4fb16
Autor:
Ruixue Liu, He Huang, Dongyao Hou, Shuai Hao, Qiao Guo, Haitang Liao, Rui Song, Yu Tian, Qian Chen, Zhenchun Luo, Daqing Ma, Liangming Liu, Chenyang Duan
Publikováno v:
Advanced Science, Vol 11, Iss 46, Pp n/a-n/a (2024)
Abstract Unfractionated heparin (UFH) is commonly used as an anticoagulant in sepsis treatment and has recently been found to have non‐anticoagulant effects, but underlying mechanisms remain unclear. This retrospective clinical data showed that UFH
Externí odkaz:
https://doaj.org/article/f2eabf8da73d4287a06b534e576591a3
Autor:
Zhiming Ye, Mingxia Deng, Yang Yang, Yuanming Song, Liangkun Weng, Wanchen Qi, Ping Ding, Yihang Huang, Can Yu, Yan Wang, Yixing Wu, Yan Zhang, Shaoying Yuan, Wenkai Nie, Luyong Zhang, Cheng Zeng
Publikováno v:
Pharmacological Research, Vol 210, Iss , Pp 107538- (2024)
Ulcerative colitis (UC) is characterized by increased cell death in intestinal epithelial cell (IEC), which compromises gut barrier function and activates inflammation. Aberrant mitochondrial dynamics have been implicated in various forms of cell dea
Externí odkaz:
https://doaj.org/article/a86e01045dd64b42b96d8f1a4220b16d
Autor:
Jingxia Du, Hongchao Li, Jingjing Song, Tingting Wang, Yibo Dong, An Zhan, Yan Li, Gaofeng Liang
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/65930a01893249b1b9dae90a8eda31ab
Autor:
Yu Zhu, Lei Kuang, Yue Wu, Haoyue Deng, Han She, Yuanqun Zhou, Jie Zhang, Liangming Liu, Tao Li
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/39be276dba444cdb86ee53412ab49633
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrotic interstitial lung diseases, which mainly existed in middle-aged and elderly people. The accumulation of reactive oxygen species (ROS) is a common characteristic of IPF.
Externí odkaz:
https://doaj.org/article/2f47a8f47fe7410f96bd820fe5cdfee2