Zobrazeno 1 - 10
of 9 135
pro vyhledávání: '"double-strand break"'
Publikováno v:
Успехи молекулярной онкологии, Vol 11, Iss 3, Pp 8-23 (2024)
Disruption of mechanisms that maintain genome stability is an essential factor of tumor progression. Accordingly, predisposition to the development of neoplasms is often associated with germline mutations in genes involved in DNA damage detection and
Externí odkaz:
https://doaj.org/article/5e40f409f8c042eaabb4eac49d3d4a98
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Background Inherited variations in DNA double-strand break (DSB) repair pathway are known to influence ovarian cancer occurrence, progression and treatment response. Despite its significance, survival-associated genetic variants within the D
Externí odkaz:
https://doaj.org/article/44b311a2d8f540fdb61b03090e943cce
Publikováno v:
Neurobiology of Disease, Vol 201, Iss , Pp 106675- (2024)
α-synuclein (αSyn) is a presynaptic and nuclear protein that aggregates in important neurodegenerative diseases such as Parkinson's Disease (PD), Parkinson's Disease Dementia (PDD) and Lewy Body Dementia (LBD). Our past work suggests that nuclear
Externí odkaz:
https://doaj.org/article/21878170bbf543eb8878f2c707f5951b
Publikováno v:
Frontiers in Epigenetics and Epigenomics, Vol 2 (2024)
Histone post-translational modifications and variants play crucial roles in the adaptability of chromatin structure, facilitating rapid responses necessary for biological processes such as transcription, replication, and DNA damage signaling. Notably
Externí odkaz:
https://doaj.org/article/e82cdfecb18a40bd8dd8a5c462e1c11b
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Background The repair of peripheral nerve injury poses a clinical challenge, necessitating further investigation into novel therapeutic approaches. In recent years, bone marrow mesenchymal stromal cell (MSC)-derived mitochondrial transfer ha
Externí odkaz:
https://doaj.org/article/0adb62b5cd9c4000b36847779653c98d
Autor:
Festo Kiragga, Konstantin Brazovskiy
Publikováno v:
Radiation Medicine and Protection, Vol 5, Iss 1, Pp 24-29 (2024)
Fast neutrons have sufficient energy to liberate recoil protons, alpha particles, and other products when they interact with the nuclei of the target material through scattering and absorption processes. Physical interactions with biological tissues
Externí odkaz:
https://doaj.org/article/356b7a2928be45bdb0fb247fc0e00184
Publikováno v:
Radiation Medicine and Protection, Vol 5, Iss 1, Pp 16-23 (2024)
The hematopoietic system is susceptible to ionizing radiation (IR), which can cause acute hematopoietic failure or long-term myelosuppression. As the most primitive cells of the hematopoietic hierarchy, hematopoietic stem cells (HSCs) maintain lifelo
Externí odkaz:
https://doaj.org/article/113e786118ea466b9980df770be7849c
Autor:
Tomoya Suzuki, Ryoya Tetsuka, Atsuya Iwasaki, Tsutomu Shimura, Ryoichi Hirayama, Asako J Nakamura
Publikováno v:
Advances in Redox Research, Vol 13, Iss , Pp 100114- (2024)
In contemporary society, humans are susceptible to various radiation-borne hazards, including exposure to therapeutic modalities using low-linear energy transfer (low-LET) radiations (X-rays and γ-rays), natural high-LET radiation sourced from cosmi
Externí odkaz:
https://doaj.org/article/ca2779aec2444d428c3cf67194b142ea
Publikováno v:
Nucleus, Vol 15, Iss 1 (2024)
ABSTRACTDNA double-strand break (DSB) is the most dangerous type of DNA damage, which may lead to cell death or oncogenic mutations. Homologous recombination (HR) and nonhomologous end-joining (NHEJ) are two typical DSB repair mechanisms. Recently, m
Externí odkaz:
https://doaj.org/article/7751d5556522435ca788274cdf66af7c
Autor:
Asli Muvaffak, Kevin G. Coleman
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundAtaxia telangiectasia-mutated (ATM) kinase is a central regulator of the DNA damage response (DDR) signaling pathway, and its function is critical for the maintenance of genomic stability in cells that coordinate a network of cellular proce
Externí odkaz:
https://doaj.org/article/25bed31213ed4a50acfbdf2081992ecd