Výsledky vyhledávání - "double negative feedback"

Akademický článek

The miR-200–Zeb1 axis regulates key aspects of β-cell function and survival in vivo

Autor: Alexandra C. Title, Pamuditha N. Silva, Svenja Godbersen, Lynn Hasenöhrl, Markus Stoffel

Publikováno v: Molecular Metabolism, Vol 53, Iss , Pp 101267- (2021)

Objective: The miR-200–Zeb1 axis regulates the epithelial-to-mesenchymal transition (EMT), differentiation, and resistance to apoptosis. A better understanding of these processes in diabetes is highly relevant, as β-cell dedifferentiation and apop

Externí odkaz: https://doaj.org/article/e229bf2c2f6941d39f712f934bc69355

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Akademický článek

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The miR-200-Zeb1 axis regulates key aspects of β-cell function and survival in vivo

Autor: Svenja Godbersen, Pamuditha N. Silva, Lynn Hasenöhrl, Alexandra C. Title, Markus Stoffel

Publikováno v: Molecular Metabolism
Molecular Metabolism, Vol 53, Iss, Pp 101267-(2021)
Molecular Metabolism, 53

Objective The miR-200–Zeb1 axis regulates the epithelial-to-mesenchymal transition (EMT), differentiation, and resistance to apoptosis. A better understanding of these processes in diabetes is highly relevant, as β-cell dedifferentiation and apopt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab341477b37288c8277923e83df480a8
https://pubmed.ncbi.nlm.nih.gov/34116231

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Multistability and consequent phenotypic plasticity in AMPK-Akt double negative feedback loop in cancer cells

Autor: Mohit Kumar Jolly, Kishore Hari, Adithya Chedere, Saurav Kumar, Annapoorni Rangarajan

Publikováno v: Journal of Clinical Medicine, Vol 10, Iss 472, p 472 (2021)
Journal of Clinical Medicine
Volume 10
Issue 3

Adaptation and survival of cancer cells to various stress and growth factor conditions is crucial for successful metastasis. A double-negative feedback loop between two serine/threonine kinases AMPK and Akt can regulate the adaptation of breast cance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15e602e51d9a8b736efc732ecfaa3512
https://doi.org/10.1101/2020.12.21.423274

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Insulin Receptors and Intracellular Ca

Autor: Igor, Pomytkin, Vsevolod, Pinelis

Publikováno v: F1000Research

Since the discovery of insulin and insulin receptors (IR) in the brain in 1978, numerous studies have revealed a fundamental role of IR in the central nervous system and its implication in regulating synaptic plasticity, long-term potentiation and de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::68745cf68e180d4c3503d291cae466bd
https://pubmed.ncbi.nlm.nih.gov/33552476

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Copy number gain of ZEB1 mediates a double-negative feedback loop with miR-33a-5p that regulates EMT and bone metastasis of prostate cancer dependent on TGF-β signaling

Autor: Qing Yang, Hong Du, Zhengquan Wu, Yingrong Lai, Xinsheng Peng, Dong Ren, Xin Zhang, Chuandong Lang, Shaofu He, Wei Guo, Yuhu Dai

Publikováno v: Theranostics

Background: The reciprocal repressive loop between ZEB1 and miRNAs has been extensively reported to play an important role in tumor progression and metastasis of various human tumor types. The aim of this study was to elucidate the role and the under

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ccbb528e0a38b188354cd31f9f43802
https://doi.org/10.7150/thno.36735

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Dysregulation of the miR-194-CUL4B negative feedback loop drives tumorigenesis in non-small-cell lung carcinoma

Autor: Changshun Shao, Xiaohua Lin, Jun Mi, Yongxin Zou, Xiang Ye, Baichun Jiang, Yaoqin Gong, Juanjuan Lu, Xiaochen Liu, Hui Zhao, Huili Hu, Bo Han

Publikováno v: Molecular Oncology

Cullin 4B (CUL4B), a scaffold protein that assembles CRL4B ubiquitin ligase complexes, is overexpressed in many types of cancers and represses many tumor suppressors through epigenetic mechanisms. However, the mechanisms by which CUL4B is upregulated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f73d7b335d99f42b183b4a4d1e55cf7f
https://doi.org/10.1002/1878-0261.12038

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A Double Negative Feedback Loop between mTORC1 and AMPK Kinases Guarantees Precise Autophagy Induction upon Cellular Stress

Autor: Gábor Bánhegyi, Bence Hajdú, Orsolya Kapuy, Marianna Holczer, Tamás Lőrincz, András Szarka

Publikováno v: International Journal of Molecular Sciences; Volume 20; Issue 22; Pages: 5543
International Journal of Molecular Sciences, Vol 20, Iss 22, p 5543 (2019)
International Journal of Molecular Sciences

Cellular homeostasis is controlled by an evolutionary conserved cellular digestive process called autophagy. This mechanism is tightly regulated by the two sensor elements called mTORC1 and AMPK. mTORC1 is one of the master regulators of proteostasis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e74aa80cbe693ec963bd433d8c9d41c

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