Tapping into the antitubercular potential of 2,5-dimethylpyrroles: A structure-activity relationship interrogation.

Autor: Semenya D; School of Cancer and Pharmaceutical Sciences, King's College London, 150 Stamford Street, SE1 9NH, London, United Kingdom., Touitou M; School of Cancer and Pharmaceutical Sciences, King's College London, 150 Stamford Street, SE1 9NH, London, United Kingdom., Masci D; School of Cancer and Pharmaceutical Sciences, King's College London, 150 Stamford Street, SE1 9NH, London, United Kingdom., Ribeiro CM; Tuberculosis Research Laboratory, School of Pharmaceutical Sciences, Sao Paulo State University (UNESP), Rod. Araraquara-Jau, km1, 14800-903, Araraquara, Brazil., Pavan FR; Tuberculosis Research Laboratory, School of Pharmaceutical Sciences, Sao Paulo State University (UNESP), Rod. Araraquara-Jau, km1, 14800-903, Araraquara, Brazil., Dos Santos Fernandes GF; School of Cancer and Pharmaceutical Sciences, King's College London, 150 Stamford Street, SE1 9NH, London, United Kingdom., Gianibbi B; Dipartimento di Biotecnologie, Chimica e Farmacia, Dipartimento di Eccellenza 2018-2022, University of Siena, via A. Moro 2, I-53100, Siena, Italy., Manetti F; Dipartimento di Biotecnologie, Chimica e Farmacia, Dipartimento di Eccellenza 2018-2022, University of Siena, via A. Moro 2, I-53100, Siena, Italy., Castagnolo D; School of Cancer and Pharmaceutical Sciences, King's College London, 150 Stamford Street, SE1 9NH, London, United Kingdom. Electronic address: d.castagnolo@ucl.ac.uk.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2022 Jul 05; Vol. 237, pp. 114404. Date of Electronic Publication: 2022 Apr 21.

Design, Synthesis, and Characterization of N-Oxide-Containing Heterocycles with in Vivo Sterilizing Antitubercular Activity.

Autor: Dos Santos Fernandes GF; São Paulo State University (UNESP) , Institute of Chemistry, Araraquara 14800060, Brazil.; São Paulo State University (UNESP) , School of Pharmaceutical Sciences, Araraquara 14800903, Brazil.; Universidad de Navarra , Department of Organic and Pharmaceutical Chemistry, Instituto de Salud Tropical, Pamplona 31008, Spain., de Souza PC; São Paulo State University (UNESP) , School of Pharmaceutical Sciences, Araraquara 14800903, Brazil.; Institute of Tuberculosis Research, University of Illinois at Chicago , Chicago, Illinois 60607, United States., Moreno-Viguri E; Universidad de Navarra , Department of Organic and Pharmaceutical Chemistry, Instituto de Salud Tropical, Pamplona 31008, Spain., Santivañez-Veliz M; Universidad de Navarra , Department of Organic and Pharmaceutical Chemistry, Instituto de Salud Tropical, Pamplona 31008, Spain., Paucar R; Universidad de Navarra , Department of Organic and Pharmaceutical Chemistry, Instituto de Salud Tropical, Pamplona 31008, Spain., Pérez-Silanes S; Universidad de Navarra , Department of Organic and Pharmaceutical Chemistry, Instituto de Salud Tropical, Pamplona 31008, Spain., Chegaev K; Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino , Turin 10124, Italy., Guglielmo S; Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino , Turin 10124, Italy., Lazzarato L; Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino , Turin 10124, Italy., Fruttero R; Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino , Turin 10124, Italy., Man Chin C; São Paulo State University (UNESP) , School of Pharmaceutical Sciences, Araraquara 14800903, Brazil., da Silva PB; São Paulo State University (UNESP) , School of Pharmaceutical Sciences, Araraquara 14800903, Brazil., Chorilli M; São Paulo State University (UNESP) , School of Pharmaceutical Sciences, Araraquara 14800903, Brazil., Solcia MC; São Paulo State University (UNESP) , School of Pharmaceutical Sciences, Araraquara 14800903, Brazil., Ribeiro CM; São Paulo State University (UNESP) , School of Pharmaceutical Sciences, Araraquara 14800903, Brazil., Silva CSP; São Paulo State University (UNESP) , School of Pharmaceutical Sciences, Araraquara 14800903, Brazil., Marino LB; São Paulo State University (UNESP) , School of Pharmaceutical Sciences, Araraquara 14800903, Brazil., Bosquesi PL; São Paulo State University (UNESP) , School of Pharmaceutical Sciences, Araraquara 14800903, Brazil., Hunt DM; Mycobacterial Metabolism and Antibiotic Research Laboratory, The Francis Crick Institute , 1 Midland Road, London NW1 1AT, United Kingdom., de Carvalho LPS; Mycobacterial Metabolism and Antibiotic Research Laboratory, The Francis Crick Institute , 1 Midland Road, London NW1 1AT, United Kingdom., de Souza Costa CA; São Paulo State University (UNESP) , School of Odontology, Araraquara 14801903, Brazil., Cho SH; Institute of Tuberculosis Research, University of Illinois at Chicago , Chicago, Illinois 60607, United States., Wang Y; Institute of Tuberculosis Research, University of Illinois at Chicago , Chicago, Illinois 60607, United States., Franzblau SG; Institute of Tuberculosis Research, University of Illinois at Chicago , Chicago, Illinois 60607, United States., Pavan FR; São Paulo State University (UNESP) , School of Pharmaceutical Sciences, Araraquara 14800903, Brazil., Dos Santos JL; São Paulo State University (UNESP) , Institute of Chemistry, Araraquara 14800060, Brazil.; São Paulo State University (UNESP) , School of Pharmaceutical Sciences, Araraquara 14800903, Brazil.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2017 Oct 26; Vol. 60 (20), pp. 8647-8660. Date of Electronic Publication: 2017 Oct 16.

Current Advances in Antitubercular Drug Discovery: Potent Prototypes and New Targets.

Autor: Dos Santos Fernandes GF, Jornada DH, de Souza PC, Chin CM, Pavan FR, Dos Santos JL; School of Pharmaceutical Sciences, State University of Sao Paulo, Zipcode: 14801- 902, Araraquara, Brazil. santosjl@fcfar.unesp.br.

Publikováno v: Current medicinal chemistry [Curr Med Chem] 2015; Vol. 22 (27), pp. 3133-61.