Novel polygenic risk score links depression-related cortical transcriptomic changes to brain morphology and symptom severity

Autor: Amy Miles, Jianxin Shi, James B. Potash, Giorgio Pistis, Enrique Castelao, Mark Adams, Jordan W. Smoller, Yuliya S. Nikolova, Glyn Lewis, Brenda W.J.H. Penninx, Martin Preisig, Dos Santos Fc, Etienne Sibille, Schubert Ko, Roy H. Perlis, Ian Jones, Miguel E. Rentería, Ahmad R. Hariri, Douglas F. Levinson, Cathryn M. Lewis, S. P. Hamilton, Lisa Jones, Myrna M. Weissman, Rudolf Uher, Enda M. Byrne, Andrew M. McIntosh, Dorret I. Boomsma, Bernhardt T. Baune

Our group developed a transcriptome-based polygenic risk score (T-PRS) that uses common genetic variants to capture ‘depression-like’ shifts in cortical gene expression. Here, we mapped T-PRS onto diagnosis and symptom severity in major depressiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::952d737da2b2213a3696abd4470a9019
https://doi.org/10.1101/2021.02.28.21251786

The vision of professional nursing in care provided to children with HIV[sic]. (Portuguese)

Autor: Menezes ANS, dos Santos FC

Publikováno v: Revista de Pesquisa: Cuidado é Fundamental; oct2011, Vol. 3 Issue 4, p2375-2386, 12p

Examining the Role of Neuroticism Polygenic Risk in Late Life Cognitive Change: A UK Biobank Study.

Autor: Akbarian N; Tanenbaum Centre for Pharmacogenetics, Molecular Brain Science, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada.; Institute of Medical Science, University of Toronto, Toronto, ON M5S 1A8, Canada., Ebrahimi M; Tanenbaum Centre for Pharmacogenetics, Molecular Brain Science, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada.; Institute of Medical Science, University of Toronto, Toronto, ON M5S 1A8, Canada., Dos Santos FC; Tanenbaum Centre for Pharmacogenetics, Molecular Brain Science, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada., Afjeh SS; Tanenbaum Centre for Pharmacogenetics, Molecular Brain Science, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada., Abdelhack M; Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada., Sanches M; Biostatistics Core, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada., Diaconescu AO; Institute of Medical Science, University of Toronto, Toronto, ON M5S 1A8, Canada.; Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada., Rajji TK; Institute of Medical Science, University of Toronto, Toronto, ON M5S 1A8, Canada.; Adult Neurodevelopment and Geriatric Psychiatry Division, Centre for Addiction and Mental Health, Toronto, ON M6J 1H4, Canada.; Department of Psychiatry, University of Toronto, Toronto, ON M5T 1R8, Canada., Felsky D; Institute of Medical Science, University of Toronto, Toronto, ON M5S 1A8, Canada.; Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada., Zai CC; Tanenbaum Centre for Pharmacogenetics, Molecular Brain Science, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada.; Institute of Medical Science, University of Toronto, Toronto, ON M5S 1A8, Canada.; Department of Psychiatry, University of Toronto, Toronto, ON M5T 1R8, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada., Kennedy JL; Tanenbaum Centre for Pharmacogenetics, Molecular Brain Science, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada.; Institute of Medical Science, University of Toronto, Toronto, ON M5S 1A8, Canada.; Department of Psychiatry, University of Toronto, Toronto, ON M5T 1R8, Canada.

Publikováno v: Behavioral sciences (Basel, Switzerland) [Behav Sci (Basel)] 2024 Sep 29; Vol. 14 (10). Date of Electronic Publication: 2024 Sep 29.

Vertical transfer of gut microbiota from dam to neonate calf in the early of life.

Autor: Gomes V; Department of Internal Medicine, Cidade Universitária, 87, Prof. Dr. Orlando Marques de Paiva Avenue, Butantã, São Paulo, 05508-270, Brazil. viviani.gomes@usp.br., Hoffmann C; Department of Food Sciences and Experimental Nutrition, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP, Brazil., Castro-Tardón DI; Department of Internal Medicine, Cidade Universitária, 87, Prof. Dr. Orlando Marques de Paiva Avenue, Butantã, São Paulo, 05508-270, Brazil., Ramos Dos Santos FC; Department of Internal Medicine, Cidade Universitária, 87, Prof. Dr. Orlando Marques de Paiva Avenue, Butantã, São Paulo, 05508-270, Brazil., Suárez-Retamozo S; Facultad de Medicina Veterinaria y Zootecnia, Universidad Peruana Cayetano Heredia, Lima, Peru., Hurley DJ; Food Animal Health and Management Program, College of Veterinary Medicine, University of Georgia, Athens, GA, 30602, USA.

Publikováno v: Scientific reports [Sci Rep] 2024 Sep 18; Vol. 14 (1), pp. 21746. Date of Electronic Publication: 2024 Sep 18.

Neurodevelopmental signature of a transcriptome-based polygenic risk score for depression.

Autor: Miles AE; Campbell Family Mental Health Research Institute at the Centre for Addiction and Mental Health, Toronto, Ontario, Canada., Rashid SS; Campbell Family Mental Health Research Institute at the Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada., Dos Santos FC; Campbell Family Mental Health Research Institute at the Centre for Addiction and Mental Health, Toronto, Ontario, Canada., Clifford KP; Campbell Family Mental Health Research Institute at the Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada., Sibille E; Campbell Family Mental Health Research Institute at the Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ontario, Canada., Nikolova YS; Campbell Family Mental Health Research Institute at the Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada. Electronic address: yuliya.nikolova@camh.ca.

Publikováno v: Psychiatry research [Psychiatry Res] 2024 Sep; Vol. 339, pp. 116030. Date of Electronic Publication: 2024 Jun 13.