Involvement of A13 dopaminergic neurons located in the zona incerta in nociceptive processing: a fiber photometry study

Autor: Shunpei Moriya, Akira Yamashita, Daiki Masukawa, Honami Setoyama, Yunsu Hwang, Akihiro Yamanaka, Tomoyuki Kuwaki

Publikováno v: Molecular Brain, Vol 13, Iss 1, Pp 1-4 (2020)

Abstract The roles of serotonergic and noradrenergic signaling in nociceptive processing in the central nervous system are well known. However, dopaminergic signaling is also relevant to various physical functions, including nociception. The zona inc

Externí odkaz: https://doaj.org/article/a1a7f8b7b81f49029b41bdd3fa8c7725

Flavonoids, the Family of Plant-Derived Antioxidants Making Inroads into Novel Therapeutic Design Against Ionizing Radiation-Induced Oxidative Stress in Parkinson’s Disease

Autor: Amirhossein Ahmadi, Simona Bungau, Sukhbir Singh, Gokhan Zengin, Aayush Sehgal, Tapan Behl, Gagandeep Kaur

Publikováno v: Current Neuropharmacology. 20:324-343

Background: Ionizing radiation from telluric sources is unceasingly an unprotected pitfall to humans. Thus, the foremost contributors to human exposure are global and medical radiations. Various evidences assembled during preceding years reveal the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::567d4ef04850065c31d7560721c319b4
https://doi.org/10.2174/1570159x19666210524152817

Overexpression of SIRT3 Suppresses Oxidative Stress-induced Neurotoxicity and Mitochondrial Dysfunction in Dopaminergic Neuronal Cells

Autor: Yu-Mi Jeon, Shinrye Lee, Hyungjun Kim, Myungjin Jo

Publikováno v: Experimental Neurobiology

Sirtuin 3 (SIRT3), a well-known mitochondrial deacetylase, is involved in mitochondrial function and metabolism under various stress conditions. In this study, we found that the expression of SIRT3 was markedly increased by oxidative stress in dopami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e90bc246ffabc6d7bf59e46e4bdc351
https://doi.org/10.5607/en21021

Nanostars Carrying Multifunctional Neurotrophic Dendrimers Protect Neurons in Preclinical In Vitro Models of Neurodegenerative Disorders

Autor: Corinne Morfill, Stanislava Pankratova, Pedro Machado, Nathalie K. Fernando, Anna Regoutz, Federica Talamona, Alessandra Pinna, Michal Klosowski, Robert J. Wilkinson, Roland A. Fleck, Fang Xie, Alexandra E. Porter, Darya Kiryushko

Publikováno v: Morfill, C, Pankratova, S, Machado, P, Fernando, N K, Regoutz, A, Talamona, F, Pinna, A, Klosowski, M, Wilkinson, R J, Fleck, R A, Xie, F, Porter, A E & Kiryushko, D 2022, ' Nanostars Carrying Multifunctional Neurotrophic Dendrimers Protect Neurons in Preclinical In Vitro Models of Neurodegenerative Disorders ', ACS applied materials & interfaces, vol. 14, no. 42, pp. 47445–47460 . https://doi.org/10.1021/acsami.2c14220

A challenge in neurology is the lack of efficient brain-penetrable neuroprotectants targeting multiple disease mechanisms. Plasmonic gold nanostars are promising candidates to deliver standard-of-care drugs inside the brain but have not been trialed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46a434b7523f65fd5823f1c295e02141
https://pubmed.ncbi.nlm.nih.gov/36218307

Estimates of Intracellular Dopamine in Parkinson’s Disease: A Systematic Review and Meta-Analysis

Autor: Jonathan Sackner-Bernstein

Publikováno v: Journal of Parkinson's Disease

Background: The hallmark of Parkinson’s disease is depletion of dopamine in the basal ganglia. Models of Parkinson’s disease include dopamine as a contributor to disease progression. However, intraneuronal levels of dopamine have not been reporte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e55118252dba89191e245cb9326e1f20
https://doi.org/10.3233/jpd-212715