Zobrazeno 1 - 10
of 2 977
pro vyhledávání: '"domain antibody"'
Autor:
Ling Wang, Ran Luo, Weilang Zhang, Hanyu Jiang, Yongkang Yu, Wenhu Zhou, Fan Zhang, Jian Ma, Lin Mei
Publikováno v:
Smart Materials in Medicine, Vol 5, Iss 4, Pp 501-513 (2024)
Nanobody (Nb) is derived from the variable domain of heavy-chain antibody (HCAb), naturally displaying notable properties like nano-scale size, exceptional stability, high specificity, low immunogenicity, and cryptic epitope accessibility. These feat
Externí odkaz:
https://doaj.org/article/46f53d81aad441afa8025d01061b7619
Autor:
Amirhosein Maali, Shahriyar Abdoli, Mahdi Habibi-Anbouhi, Ahmad Noei, Maryam Kadkhodazadeh, Mahdieh Motamedirad, Arash Arashkia, Zahra Sharifzadeh
Publikováno v:
Cell Journal, Vol 26, Iss 8, Pp 487-495 (2024)
Objective: CD22, as a surface protein of B cells, is used in the diagnosis and target-specific immunotherapy of B-cellmalignancies. SpyTag and SpyCatcher, on the other hand, are two covalently coupled proteins capable of developinga bi- or multi-spec
Externí odkaz:
https://doaj.org/article/ea88165a54bb43b9b785f225dccaeb17
Autor:
Faith Njeru, Olivier Zwaenepoel, Geert Haesaert, Gerald Misinzo, Kris De Jonghe, Jan Gettemans
Publikováno v:
FEBS Open Bio, Vol 14, Iss 10, Pp 1746-1757 (2024)
Maize lethal necrosis (MLN) is a maize disease caused by the maize chlorotic mottle virus (MCMV), a potyvirus which causes yield losses of 30–100%. The present study aimed to isolate nanobodies against the MCMV coat protein (CP) for the diagnosis o
Externí odkaz:
https://doaj.org/article/5793225ef1094772b0488fe26004168c
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 7, Pp 2854-2868 (2024)
Single-domain antibodies (sdAbs), initially identified in camelids or sharks and commonly referred to as nanobodies or VNARs, have emerged as a promising alternative to conventional therapeutic antibodies. These sdAbs have many superior physicochemic
Externí odkaz:
https://doaj.org/article/9520c9a554d343f3aadcc97206844ed8
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/829a5a1aef224bbaacda2646c80bd624
Autor:
Christine N. Vuong, Kevin M. Reynolds, Gerry S. Rivera, Baisen Zeng, Zahra Karimpourkalou, Manith Norng, Yulei Zhang, Robayet Chowdhury, Darlene Pedersen, Melissa Pantoja, Ellen Collarini, Swetha Garimalla, Shelley Izquierdo, Eric G. Vajda, Brett Antonio, Devendra B. Srivastava, Marie-Cecile van de Lavoir, Yasmina Abdiche, William Harriman, Philip A. Leighton
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
Heavy chain-only antibodies have found many applications where conventional heavy-light heterodimeric antibodies are not favorable. Heavy chain-only antibodies with their single antigen-binding domain offer the advantage of a smaller size and higher
Externí odkaz:
https://doaj.org/article/e1ab1681fce44c14a4eb463c71ee1174
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionVHHs (VH of heavy-chain-only antibodies) represent a unique alternative to Q7 conventional antibodies because of their smaller size, comparable binding affinity and biophysical properties. MethodIn this study, we systematically analyzed V
Externí odkaz:
https://doaj.org/article/1f8529b9ff544d39895d20d7960b777e
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Using conventional immunoglobulin G (IgG) molecules as therapeutic agents presents several well-known disadvantages owing to their large size and structural complexity, negatively impacting development and production efficiency. Single-domai
Externí odkaz:
https://doaj.org/article/d86067ade20f4a04a6a1aa6bb6b3d357
Autor:
Lisa A. King, Milon de Jong, Myrthe Veth, David Lutje Hulsik, Parsa Yousefi, Victoria Iglesias-Guimarais, Pauline M. van Helden, Tanja D. de Gruijl, Hans J. van der Vliet
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundVγ9Vδ2 T-cells are antitumor immune effector cells that can detect metabolic dysregulation in cancer cells through phosphoantigen-induced conformational changes in the butyrophilin (BTN) 2A1/3A1 complex. In order to clinically exploit the
Externí odkaz:
https://doaj.org/article/3eb04d8fffbe403ba273566ef54bbcbc
Autor:
Behnam Hasannejad-Asl, Hassan Hashemzadeh, Farkhondeh Pooresmaeil, Mehran Dabiri, Mohammad-Reza Pooresmaeil, Davoud Ahmadvand, Arshad Hosseini
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
IntroductionDuring the last decade, there has been a significant rise in the use of therapeutic antibodies or passive immunotherapy for treating various conditions like inflammation and cancer. However, these proteins face challenges reaching the bra
Externí odkaz:
https://doaj.org/article/5b8d13ba525b4be5842b0305ec777ae6