Zobrazeno 1 - 10
of 1 462
pro vyhledávání: '"docking analysis"'
Autor:
Hamdoon A. Mohammed, Rana Said, Manal M. Abbas, Belal O. Al-Najjar, Essam Abd-Elmoniem, Riaz A. Khan, Abdullah S. Alsohim, Suliman A. Almahmoud, Taha A. Kedra, Safia M. Shehata, Ahmed Ismail
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Ephedra alata Decne is a medicinal plant widely used in traditional medicine for the management of bronchial asthma and cancer. Phytochemical analysis and biological activities, including antioxidant and anticancer effects, were investigated
Externí odkaz:
https://doaj.org/article/5fa586ba4e8942cebdac8a4b709b440b
Autor:
Adam Mustapha, Ahmed Nouri AlSharksi, Ukpai A. Eze, Rahma Kudla Samaila, Boniface Nwofoke Ukwah, Arinze Favour Anyiam, Shivanthi Samarasinghe, Musa Adamu Ibrahim
Publikováno v:
BioMed, Vol 4, Iss 3, Pp 277-292 (2024)
Klebsiella pneumoniae is an opportunistic Gram-negative bacterium in the Enterobacteriaceae family associated with a wide range of diseases, such as pneumonia, bloodstream infections, meningitis and urinary tract infections. Infections caused by drug
Externí odkaz:
https://doaj.org/article/6f9d8874846d4e819cbf014fc0575c09
Autor:
Chaochao Gong, Zhuoqi Chen, Yunbing Tang, Han Lu, Sailing Chen, Yang Zhu, Ren-shan Ge, Junzhao Zhao
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 286, Iss , Pp 117244- (2024)
Aromatase (CYP19A1), a pivotal enzyme in the biosynthesis of estradiol from testosterone, is predominantly expressed in reproductive tissues including placentas. This study investigated the effects of paraben acid and nine parabens on the activity of
Externí odkaz:
https://doaj.org/article/50175f4a2f904ad495b7fb8f1cd51844
Autor:
Chunyan Zhao, Zelin Li, Yusuf Chisti, Shuwen Lei, Yue Miao, Huijuan Liu, Jiashun Gong, Qiuping Wang
Publikováno v:
Journal of Functional Foods, Vol 121, Iss , Pp 106440- (2024)
The leaves of Metapanax delavayi shrub have been widely used in Chinese traditional diet to prepare tea-like beverages for alleviating inflammation. This study aimed to identify phytochemical components of M. delavayi leaf extract (MDE), and assess t
Externí odkaz:
https://doaj.org/article/a5169b9a251d4f719c56db73fc935e15
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 283, Iss , Pp 116852- (2024)
Dithiocarbamates have been widely used in various industrial applications, such as insecticides (ferbam) or drug (disulfiram). This study explored the inhibitory effects of dithiocarbamates on human and rat gonadal 3β-hydroxysteroid dehydrogenases (
Externí odkaz:
https://doaj.org/article/df252a107121430586636d6d33820e6f
Autor:
A. S. Akisheva, V. B. Larionov, M. Y. Golovenko, O. A. Makarenko, I. P. Valivodz, I. Y. Borysiuk, Y. O. Molodan
Publikováno v:
Regulatory Mechanisms in Biosystems, Vol 15, Iss 2, Pp 327-336 (2024)
Recently, scientists have established that several benzodiazepines were found to enhance the activation of a cAMP response element pathway by α1A-adrenergic receptors, but this effect was attributed to off-target inhibition of phosphodiesterases 4.
Externí odkaz:
https://doaj.org/article/e3ac540fd3f349c09aa62b8701c85f60
Autor:
Thaniwan Cheun-Arom, Tharita Kitisripanya, Poomraphie Nuntawong, Boonchoo Sritularak, Taksina Chuanasa
Publikováno v:
Heliyon, Vol 10, Iss 14, Pp e34502- (2024)
Eight compounds, including one anthraquinone, two bibenzyls, one phenanthrene, three dihydrophenanthrenes, and one flavonoid, were isolated from the roots of Dendrobium polyanthum Wall. ex Lindl. Among these, six compounds were investigated for inhib
Externí odkaz:
https://doaj.org/article/5166d97aa5fa4988ac965182158a952c
Autor:
Md Sahadot Hossen, Adiba Akter, Mahir Azmal, Mostakim Rayhan, Kazi Saiful Islam, Md Mahmodul Islam, Shamim Ahmed, Mohammad Abdullah-Al-Shoeb
Publikováno v:
Biochemistry and Biophysics Reports, Vol 38, Iss , Pp 101727- (2024)
Background and aim: N-acetyl-p-benzoquinoneimine (NAPQI), a toxic byproduct of paracetamol (Acetaminophen, APAP), can accumulate and cause liver damage by depleting glutathione and forming protein adducts in the mitochondria. These adducts disrupt th
Externí odkaz:
https://doaj.org/article/9b6d915b9306406baf391972a50ba104
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Background: Ischemic Stroke (IS) stands as one of the primary cerebrovascular diseases profoundly linked with inflammation. In the context of neuroinflammation, an excessive activation of microglia has been observed. Consequently, regulating microgli
Externí odkaz:
https://doaj.org/article/5cd7dc5be83a412bad83bf4b1baff113
Publikováno v:
Asian Journal of Surgery, Vol 47, Iss 3, Pp 1533-1535 (2024)
Externí odkaz:
https://doaj.org/article/936307e6c93a4cc2a9751e546167eeb3