Zobrazeno 1 - 10
of 3 460
pro vyhledávání: '"dnmt3a"'
Autor:
Naomi Kawashima, Yasuo Kubota, Carlos Bravo-Perez, Luca Guarnera, Nakisha D. Williams, Arda Durmaz, Michaela Witt, Arooj Ahmed, Carmelo Gurnari, Jaroslaw P. Maciejewski, Valeria Visconte
Publikováno v:
Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-6 (2024)
Abstract DNA methyltransferase 3 A mutations (DNMT3A MT) are frequent in myeloid neoplasia (MN) and mostly heterozygous. However, cases with multiple DNMT3A MT can be also encountered but their clinical and genetic landscape remains unexplored. We re
Externí odkaz:
https://doaj.org/article/eb8828e15ae0440189a9cfafde31b70a
Autor:
Ahmed Mahmoud Taha Khattab, Afaf Abdel Aziz Abdel Ghaffar, Dalia Ahmed El-Sewefy, Yasmin Nabil ElSakhawy, Ramy Mahmoud Salem, Heba Samy Agamy Omar
Publikováno v:
Egyptian Journal of Medical Human Genetics, Vol 25, Iss 1, Pp 1-13 (2024)
Abstract Background Acute myeloid leukemia (AML) is a clonal disorder arising from the differentiation arrest of myeloid precursor and malignant proliferation of a bone marrow derived, self-renewing stem or progenitor cells inside the bone marrow (BM
Externí odkaz:
https://doaj.org/article/7e76366d8a6c4daa8df12b2705bac6ed
Autor:
Genki Kudo, Takumi Hirao, Ryuhei Harada, Takatsugu Hirokawa, Yasuteru Shigeta, Ryunosuke Yoshino
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract DNA methylation is an epigenetic mechanism that introduces a methyl group at the C5 position of cytosine. This reaction is catalyzed by DNA methyltransferases (DNMTs) and is essential for the regulation of gene transcription. The DNMT1 and D
Externí odkaz:
https://doaj.org/article/b38df8e4c2e54e1aaa78f6499faa8322
Autor:
Dovile Zebrauskiene, Egle Sadauskiene, Justas Dapkunas, Visvaldas Kairys, Joris Balciunas, Aleksandras Konovalovas, Ruta Masiuliene, Gunda Petraityte, Nomeda Valeviciene, Mindaugas Mataciunas, Jurate Barysiene, Violeta Mikstiene, Migle Tomkuviene, Egle Preiksaitiene
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-15 (2024)
Abstract Tatton-Brown–Rahman syndrome (TBRS) is a rare congenital genetic disorder caused by autosomal dominant pathogenic variants in the DNA methyltransferase DNMT3A gene. Typical TBRS clinical features are overgrowth, intellectual disability, an
Externí odkaz:
https://doaj.org/article/1c9dd59da3c14eceb348640c7603e7f9
Autor:
Xuelei Liu, Jingjing Wang, Ziyi Yang, Qipeng Xie, Xinqi Diao, Xiaoyan Yao, Shirui Huang, Ruifan Chen, Yunping Zhao, Tengda Li, Minghua Jiang, Zhefeng Lou, Chuanshu Huang
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 286, Iss , Pp 117157- (2024)
NNK, formally known as 4-(methyl nitrosamine)-1-(3-pyridyl)-1-butanoe, is a potent chemical carcinogen prevalent in cigarette smoke and is a key contributor to the development of human lung adenocarcinomas. On the other hand, autophagy plays a comple
Externí odkaz:
https://doaj.org/article/3bb11761066d46debba545ae147eee7d
Autor:
Jianling GUO, Huijie JIA
Publikováno v:
Journal of Applied Oral Science, Vol 32 (2024)
Abstract Background and objective Periodontitis is an inflammatory disease typically characterized by the destruction of periodontal tissues and complicated etiology. DNA methyltransferase 3A (DNMT3A) has been implicated in possessing pro-inflammator
Externí odkaz:
https://doaj.org/article/817df6c1e4434a809a5f5c3e372af3d9
Autor:
Khairunnisa Mohd Kamal, Ahmad Rohi Ghazali, Nurul Syakima Ab Mutalib, Nadiah Abu, Eng Wee Chua, Siti Fathiah Masre
Publikováno v:
Heliyon, Vol 10, Iss 19, Pp e38663- (2024)
Lung cancer as the second most death cancer reported cases is becoming a major threat to the global healthcare system. With the different subtypes of lung cancer and their limited therapy options due to the lack of targetable genes, rising cases of t
Externí odkaz:
https://doaj.org/article/0834229e87f2481abc309a1bd41f9c8f
Publikováno v:
Clinics and Practice, Vol 14, Iss 3, Pp 928-933 (2024)
Tatton–Brown–Rahman syndrome is a rare autosomal dominant hereditary disease caused by pathogenic variants in the DNMT3A gene, which is an important participant in epigenetic regulation, especially during embryonic development, and is highly expr
Externí odkaz:
https://doaj.org/article/2595bc68969147bdaef5ea35068678a1
Publikováno v:
Cellular & Molecular Biology Letters, Vol 29, Iss 1, Pp 1-20 (2024)
Abstract Background Viral myocarditis (VMC) is a disease resulting from viral infection, which manifests as inflammation of myocardial cells. Until now, the treatment of VMC is still a great challenge for clinicians. Increasing studies indicate the p
Externí odkaz:
https://doaj.org/article/ac460027ef054f72bd0994194463f114
Autor:
Mio Harachi, Kenta Masui, Erika Shimizu, Kumiko Murakami, Hiromi Onizuka, Yoshihiro Muragaki, Takakazu Kawamata, Hisako Nakayama, Mariko Miyata, Takashi Komori, Webster K. Cavenee, Paul S. Mischel, Atsushi Kurata, Noriyuki Shibata
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-17 (2024)
Abstract DNA methylation is crucial for chromatin structure and gene expression and its aberrancies, including the global “hypomethylator phenotype”, are associated with cancer. Here we show that an underlying mechanism for this phenotype in the
Externí odkaz:
https://doaj.org/article/59ba976a12834ee782df85c5cc6333ba