Zobrazeno 1 - 10
of 1 845
pro vyhledávání: '"dna-pkcs"'
Autor:
Henrike Barbara Zech, Clara von Bargen, Agnes Oetting, Nikolaus Möckelmann, Christina Möller-Koop, Melanie Witt, Nina Struve, Cordula Petersen, Christian Betz, Kai Rothkamm, Adrian Münscher, Till Sebastian Clauditz, Thorsten Rieckmann
Publikováno v:
Radiation Oncology, Vol 19, Iss 1, Pp 1-11 (2024)
Abstract Background Head and neck squamous cell carcinoma (HNSCC) negative for Human Papillomavirus (HPV) has remained a difficult to treat entity, whereas tumors positive for HPV are characterized by radiosensitivity and favorable patient outcome. O
Externí odkaz:
https://doaj.org/article/c1e43d1aa9b54a65af428ae6df20aafc
Publikováno v:
PeerJ, Vol 12, p e18489 (2024)
Neuronal apoptosis, oxidative stress, and ferroptosis play a crucial role in the progression of secondary brain injury following intracerebral hemorrhage (ICH). Although studies have highlighted the important functions of DNA-dependent protein kinase
Externí odkaz:
https://doaj.org/article/177e642b68964128a0d299fe5f81ec11
Publikováno v:
Neurobiology of Disease, Vol 201, Iss , Pp 106675- (2024)
α-synuclein (αSyn) is a presynaptic and nuclear protein that aggregates in important neurodegenerative diseases such as Parkinson's Disease (PD), Parkinson's Disease Dementia (PDD) and Lewy Body Dementia (LBD). Our past work suggests that nuclear
Externí odkaz:
https://doaj.org/article/21878170bbf543eb8878f2c707f5951b
Autor:
Yuhao Liu, Jiaojiao Zhu, Shenghui Zhou, Yifan Hou, Ziyan Yan, Xingkun Ao, Ping Wang, Lin Zhou, Huixi Chen, Xinxin Liang, Hua Guan, Shanshan Gao, Dafei Xie, Yongqing Gu, Ping‐Kun Zhou
Publikováno v:
MedComm, Vol 5, Iss 8, Pp n/a-n/a (2024)
Abstract Thyroid cancer incidence increases worldwide annually, primarily due to factors such as ionizing radiation (IR), iodine intake, and genetics. Papillary carcinoma of the thyroid (PTC) accounts for about 80% of thyroid cancer cases. RET/PTC1 (
Externí odkaz:
https://doaj.org/article/5f76360a4bb247c7a8426fd84949409c
Autor:
Chenxin Xu, Guoyu Chen, Bo Yu, Bowen Sun, Yingwen Zhang, Mingda Zhang, Yi Yang, Yichuan Xiao, Shi‐Yuan Cheng, Yanxin Li, Haizhong Feng
Publikováno v:
Advanced Science, Vol 11, Iss 29, Pp n/a-n/a (2024)
Abstract The factors driving glioma progression remain poorly understood. Here, the epigenetic regulator TRIM24 is identified as a driver of glioma progression, where TRIM24 overexpression promotes HRasV12 anaplastic astrocytoma (AA) progression into
Externí odkaz:
https://doaj.org/article/4533c20a70e64f66876871ae4421263b
Publikováno v:
MedComm, Vol 5, Iss 7, Pp n/a-n/a (2024)
Abstract The DNA‐dependent protein kinase (DNA‐PK), catalytic subunit, also known as DNA‐PKcs, is complexed with the heterodimer Ku70/Ku80 to form DNA‐PK holoenzyme, which is well recognized as initiator in the nonhomologous end joining (NHEJ
Externí odkaz:
https://doaj.org/article/78b9536866554de990089e73b83d871b
Autor:
Ziyan Yan, Jiaojiao Zhu, Yuhao Liu, Zhongqiu Li, Xinxin Liang, Shenghui Zhou, Yifan Hou, Huixi Chen, Lin Zhou, Ping Wang, Xingkun Ao, Shanshan Gao, Xin Huang, Ping‐Kun Zhou, Yongqing Gu
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 5, Pp n/a-n/a (2024)
Abstract Introduction Radiation‐induced pulmonary fibrosis (RIPF) is a chronic, progressive, irreversible lung interstitial disease that develops after radiotherapy. Although several previous studies have focused on the mechanism of epithelial–me
Externí odkaz:
https://doaj.org/article/d2752eac8b304b11a1bef51b72c13e9a
Publikováno v:
Cells, Vol 13, Iss 17, p 1462 (2024)
DNA double strand breaks (DSBs) are critical for the efficacy of radiotherapy as they lead to cell death if not repaired. DSBs caused by ionizing radiation (IR) initiate histone modifications and accumulate DNA repair proteins, including 53BP1, which
Externí odkaz:
https://doaj.org/article/4852a50ac084453b848499be8101e3c2
Autor:
Sk Imran Ali, Mohammad J. Najaf-Panah, Kennedi B. Pyper, F. Ester Lujan, Johnny Sena, Amanda K. Ashley
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
Background: Maintenance of the genome is essential for cell survival, and impairment of the DNA damage response is associated with multiple pathologies including cancer and neurological abnormalities. DNA-PKcs is a DNA repair protein and a core compo
Externí odkaz:
https://doaj.org/article/19e3b32b6e184683acc3ecd9c8efe1c9
Autor:
Litao Wang, Lin Wu, Yuxin Du, Xiang Wang, Bingsheng Yang, Shuai Guo, Yuan Zhou, Yiming Xu, Shuofei Yang, Yingmei Zhang, Jun Ren
Publikováno v:
Redox Biology, Vol 67, Iss , Pp 102893- (2023)
Background: DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a novel instigator for mitochondrial dysfunction, and plays an important role in the pathogenesis of cardiovascular diseases. However, the role and mechanism of DNA-PKcs in angi
Externí odkaz:
https://doaj.org/article/0b0848831a1243188a7fce4133af0866