Zobrazeno 1 - 10
of 19 155
pro vyhledávání: '"dna damage response"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract This study aimed to investigate whether the plant DNA damage levels and DNA damage response (DDR) are regulated during Agrobacterium infection and potentially manipulated by Agrobacterium to facilitate T-DNA integration. We investigated the
Externí odkaz:
https://doaj.org/article/2b55dcf9b80e4dfaafa4d0e1da100bf7
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract The DNA damage response is a highly conserved protective mechanism that enables cells to cope with various lesions in the genome. Extensive studies across different eukaryotic cells have identified the crucial roles played by components requ
Externí odkaz:
https://doaj.org/article/9e4b3efb26ad4166a50e46d6622e2966
Autor:
Haihua Yuan, Renjie Cai, Biying Chen, Qian Wang, Mengting Wang, Junyi An, Weishu An, Ye Tao, Jianxiu Yu, Bin Jiang, Yanjie Zhang, Ming Xu
Publikováno v:
Molecular Oncology, Vol 18, Iss 9, Pp 2314-2330 (2024)
Androgen‐regulated DNA damage response (DDR) is one of the essential mechanisms in prostate cancer (PCa), a hormone‐sensitive disease. The heterogeneous nuclear ribonucleoprotein K (hnRNPK)‐homology splicing regulatory protein known as far upst
Externí odkaz:
https://doaj.org/article/9a39442787ce423ba7555c833b7e0f53
Autor:
Jiayi Li, Ziqi Jia, Lin Dong, Heng Cao, Yansong Huang, Hengyi Xu, Zhixuan Xie, Yiwen Jiang, Xiang Wang, Jiaqi Liu
Publikováno v:
Biomarker Research, Vol 12, Iss 1, Pp 1-32 (2024)
Abstract DNA damage response (DDR) deficiency has been one of the emerging targets in treating breast cancer in recent years. On the one hand, DDR coordinates cell cycle and signal transduction, whose dysfunction may lead to cell apoptosis, genomic i
Externí odkaz:
https://doaj.org/article/022406c0024840c49cd64f88da50a85b
Autor:
You Zuo, Jiaqian He, Zheng Zhou, Jingjing Sun, Can Ouyang, Hui Huang, Yajuan Wang, Hairong Liu, Simon H. Reed
Publikováno v:
Non-coding RNA Research, Vol 9, Iss 3, Pp 649-658 (2024)
In recent years, various long non-coding RNAs (lncRNAs) involved in DNA damage response (DDR) have been identified and studied to deepen our understanding. However, there are rare reports on the association between lncRNAs and base excision repair (B
Externí odkaz:
https://doaj.org/article/f6e460879406499fb1d08933b6cbb872
Autor:
Yingying Zhang, Shuting Qiu, Shihan Shao, Yuejia Cao, Yu Hong, Xianrong Xu, Xuexian Fang, Chunhong Di, Jun Yang, Xiaohua Tan
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Cuproptosis is characterized by lipoylated protein aggregation and loss of iron–sulfur (Fe–S) proteins, which are crucial for a wide range of important cellular functions, including DNA replication and damage repair. Sirt2 and sirt4 are
Externí odkaz:
https://doaj.org/article/61c0e6a1b4d84978bce159df7d1337e7
Autor:
Xiuhua Xu, Ziwei Wang, Luyi Lv, Ci Liu, Lili Wang, Ya-nan Sun, Zhiming Zhao, Baojun Shi, Qian Li, Gui-min Hao
Publikováno v:
Reproductive Biology and Endocrinology, Vol 22, Iss 1, Pp 1-13 (2024)
Abstract DNA damage is a key factor affecting gametogenesis and embryo development. The integrity and stability of DNA are fundamental to a woman’s successful conception, embryonic development, pregnancy and the production of healthy offspring. Agi
Externí odkaz:
https://doaj.org/article/409da229c96749328423929a723aa945
Publikováno v:
Military Medical Research, Vol 11, Iss 1, Pp 1-36 (2024)
Abstract Small nucleolar RNAs (snoRNAs) were previously regarded as a class of functionally conserved housekeeping genes, primarily involved in the regulation of ribosome biogenesis by ribosomal RNA (rRNA) modification. However, some of them are invo
Externí odkaz:
https://doaj.org/article/c322321cb98548d28b7a45eb169a40f2
Autor:
Yuichiro Nakata, Shion Nagasawa, Yasuyuki Sera, Norimasa Yamasaki, Akinori Kanai, Kohei Kobatake, Takeshi Ueda, Miho Koizumi, Ichiro Manabe, Osamu Kaminuma, Hiroaki Honda
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract The genome is constantly exposed to DNA damage from endogenous and exogenous sources. Fine modulation of DNA repair, chromatin remodeling, and transcription factors is necessary for protecting genome integrity, but the precise mechanisms are
Externí odkaz:
https://doaj.org/article/82b7b77af190493ea855123415683089
Publikováno v:
Animal Cells and Systems, Vol 28, Iss 1, Pp 401-416 (2024)
Lamin A/C, a core component of the nuclear lamina, forms a mesh-like structure beneath the inner nuclear membrane. While its structural role is well-studied, its involvement in DNA metabolism remains unclear. We conducted sequential protein fractiona
Externí odkaz:
https://doaj.org/article/252959cfcbaf45b6943abeaefa027f3e