Zobrazeno 1 - 10
of 4 924
pro vyhledávání: '"dna damage repair"'
Autor:
Yilin Yan, Zhengnan Huang, Zhen Zhu, Yang Wang, Xiangqian Cao, Chenkai Yang, Junfeng Jiang, Shujie Xia, Bing Shen
Publikováno v:
Cancer Cell International, Vol 24, Iss 1, Pp 1-18 (2024)
Abstract Background Cisplatin resistance is the leading cause of mortality in muscle-invasive bladder cancer (MIBC) cases. Previous evidence suggests that abnormal epitranscriptome modifications are associated with reduced chemotherapy responses. How
Externí odkaz:
https://doaj.org/article/cd9b8d4ceacc478ca03a5b0f43641bcf
Autor:
Clare E. Murray, Anand V. R. Kornepati, Carlos Ontiveros, Yiji Liao, Bárbara de la Peña Avalos, Cody M. Rogers, Zexuan Liu, Yilun Deng, Haiyan Bai, Suresh Kari, Alvaro S. Padron, Jacob T. Boyd, Ryan Reyes, Curtis A. Clark, Robert S. Svatek, Rong Li, Yanfen Hu, Meiling Wang, José R. Conejo-Garcia, Lauren A. Byers, Kavya Ramkumar, Anil K. Sood, Jung-Min Lee, Christin E. Burd, Ratna K. Vadlamudi, Harshita B. Gupta, Weixing Zhao, Eloïse Dray, Patrick Sung, Tyler J. Curiel
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-24 (2024)
Abstract Background Aside from the canonical role of PDL1 as a tumour surface-expressed immune checkpoint molecule, tumour-intrinsic PDL1 signals regulate non-canonical immunopathological pathways mediating treatment resistance whose significance, me
Externí odkaz:
https://doaj.org/article/324b033e9fa34bbcab45721b8054a03a
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Background Premature ovarian insufficiency (POI) is a condition characterized by a substantial decline or loss of ovarian function in women before the age of 40. However, the pathogenesis of POI remains to be further elucidated, and specific
Externí odkaz:
https://doaj.org/article/e20c4fe7f59347679d2ea0f76ba4bea5
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract The recA gene, encoding Recombinase A (RecA) is one of three Mycobacterium tuberculosis (Mtb) genes encoding an in-frame intervening protein sequence (intein) that must splice out of precursor host protein to produce functional protein. Ongo
Externí odkaz:
https://doaj.org/article/c1127ed367c04b0ca3a5d5a5bbfbf0a8
Autor:
Jangsoon Lee, Kumiko Kida, Jiwon Koh, Huey Liu, Ganiraju C. Manyam, Young Jin Gi, Dileep R. Rampa, Asha S. Multani, Jing Wang, Gitanjali Jayachandran, Dae-Won Lee, James M. Reuben, Aysegul Sahin, Lei Huo, Debu Tripathy, Seock-Ah Im, Naoto T. Ueno
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-20 (2024)
Abstract Background Anti-HER2 therapies, including the HER2 antibody–drug conjugates (ADCs) trastuzumab emtansine (T-DM1) and trastuzumab deruxtecan (T-DXd), have led to improved survival outcomes in patients with HER2-overexpressing (HER2+) metast
Externí odkaz:
https://doaj.org/article/96dec9fe852b4c2f9909c30d5560016b
Publikováno v:
Military Medical Research, Vol 11, Iss 1, Pp 1-36 (2024)
Abstract Small nucleolar RNAs (snoRNAs) were previously regarded as a class of functionally conserved housekeeping genes, primarily involved in the regulation of ribosome biogenesis by ribosomal RNA (rRNA) modification. However, some of them are invo
Externí odkaz:
https://doaj.org/article/c322321cb98548d28b7a45eb169a40f2
Autor:
Jianhao Zhan, Le Huang, Liyan Niu, Wenhui Lu, Chengpeng Sun, Shanshan Liu, Zijun Ding, Enliang Li
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract CD73, a cell surface-bound nucleotidase, serves as a crucial metabolic and immune checkpoint. Several studies have shown that CD73 is widely expressed on immune cells and plays a critical role in immune escape, cell adhesion and migration as
Externí odkaz:
https://doaj.org/article/83a99b15405240b2a21ea2d12b54b4f6
Autor:
Paola Matarrese, Michele Signore, Barbara Ascione, Giulia Fanelli, Marco G. Paggi, Claudia Abbruzzese
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract Background In the fight against GBM, drug repurposing emerges as a viable and time-saving approach to explore new treatment options. Chlorpromazine, an old antipsychotic medication, has recently arisen as a promising candidate for reposition
Externí odkaz:
https://doaj.org/article/b458107db2704a578e8f65b37811408e
Autor:
Melissa R. Laughter, MD, PhD, Cosmin A. Tegla, MD, Shashi Pawar, PhD, Ata S. Moshiri, MD, MPH, Seth J. Orlow, MD, PhD
Publikováno v:
JAAD Case Reports, Vol 49, Iss , Pp 28-31 (2024)
Externí odkaz:
https://doaj.org/article/93bda948a5a947e1b0d01ef4f681aecc
Autor:
Mingxing An, Congcong Chen, Jun Xiang, Yang Li, Pinyu Qiu, Yiru Tang, Xinyue Liu, Yayun Gu, Na Qin, Yuanlin He, Meng Zhu, Yue Jiang, Juncheng Dai, Guangfu Jin, Hongxia Ma, Cheng Wang, Zhibin Hu, Hongbing Shen
Publikováno v:
EBioMedicine, Vol 110, Iss , Pp 105480- (2024)
Summary: Background: Deficiency in DNA-damage repair (DDR) genes, often due to disruptive coding variants, is linked to higher cancer risk. Our previous study has revealed the association between rare loss-of-function variants in DDR genes and the ri
Externí odkaz:
https://doaj.org/article/13489c305f1448f98149ba4a9aa2f4fc