Carboxy-terminal polyglutamylation regulates signaling and phase separation of the Dishevelled protein.

Autor: Kravec M; Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic., Šedo O; Central European Institute of Technology (CEITEC), Brno, Czech Republic., Nedvědová J; Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV, Vestec, Czech Republic.; Department of Biochemistry, Faculty of Science, Charles University, Prague, Czech Republic., Micka M; Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic.; Central European Institute of Technology (CEITEC), Brno, Czech Republic., Šulcová M; Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic., Zezula N; Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic., Gömöryová K; Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic., Potěšil D; Central European Institute of Technology (CEITEC), Brno, Czech Republic., Sri Ganji R; Central European Institute of Technology (CEITEC), Brno, Czech Republic., Bologna S; Central European Institute of Technology (CEITEC), Brno, Czech Republic., Červenka I; Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic., Zdráhal Z; Central European Institute of Technology (CEITEC), Brno, Czech Republic., Harnoš J; Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic., Tripsianes K; Central European Institute of Technology (CEITEC), Brno, Czech Republic., Janke C; Institut Curie, Université PSL, CNRS UMR3348, Orsay, France.; Université Paris-Saclay, CNRS UMR3348, Orsay, France., Bařinka C; Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV, Vestec, Czech Republic., Bryja V; Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic. bryja@sci.muni.cz.

Publikováno v: The EMBO journal [EMBO J] 2024 Nov; Vol. 43 (22), pp. 5635-5666. Date of Electronic Publication: 2024 Sep 30.

Structural basis of Frizzled 4 in recognition of Dishevelled 2 unveils mechanism of WNT signaling activation.

Autor: Qian Y; Laboratory of Receptor Structure and Signaling, HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, China., Ma Z; Laboratory of Receptor Structure and Signaling, HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, China., Xu Z; Laboratory of Receptor Structure and Signaling, HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, China., Duan Y; Laboratory of Receptor Structure and Signaling, HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, China., Xiong Y; Laboratory of Receptor Structure and Signaling, HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, China., Xia R; Laboratory of Receptor Structure and Signaling, HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, China., Zhu X; Laboratory of Receptor Structure and Signaling, HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, China., Zhang Z; School of Life Science and Technology, Harbin Institute of Technology, Harbin, China., Tian X; School of Life Science and Technology, Harbin Institute of Technology, Harbin, China., Yin H; Laboratory of Receptor Structure and Signaling, HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, China., Liu J; Laboratory of Receptor Structure and Signaling, HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, China., Song J; Laboratory of Receptor Structure and Signaling, HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, China., Lu Y; Laboratory of Receptor Structure and Signaling, HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, China., Zhang A; School of Life Science and Technology, Harbin Institute of Technology, Harbin, China., Guo C; School of Life Science and Technology, Harbin Institute of Technology, Harbin, China., Jin L; Northeast Forestry University, Harbin, China., Kim WJ; Laboratory of Receptor Structure and Signaling, HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, China., Ke J; Institute of Health and Medicine, Hefei Comprehensive National Science Center, Hefei, China., Xu F; iHuman Institute, ShanghaiTech University, Shanghai, China., Huang Z; School of Life Science and Technology, Harbin Institute of Technology, Harbin, China., He Y; Laboratory of Receptor Structure and Signaling, HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, China. ajian.he@hit.edu.cn.

Publikováno v: Nature communications [Nat Commun] 2024 Sep 02; Vol. 15 (1), pp. 7644. Date of Electronic Publication: 2024 Sep 02.

The Dishevelled Duke

Autor: Catherine Curzon, Eleanor Harkstead

From the A Little Bit Cupid collection Will a photographer be swept off his feet by a duke who's more dishevelled than dashing? It's Valentine's Day and it's Billy last shift at The Chelsea Bunn. His photography career never took off, so it's time to

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A Van Gogh/Vangl tyrosine phosphorylation switch regulates its interaction with core Planar Cell Polarity factors Prickle and Dishevelled.

Autor: Humphries AC; Dept. of Cell, Developmental, & Regenerative Biology,Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Molina-Pelayo C; Dept. of Cell, Developmental, & Regenerative Biology,Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Sil P; Dept. of Molecular Biology Princeton University, Princeton, New Jersey, United States of America., Hazelett CC; Dept. of Molecular Biology Princeton University, Princeton, New Jersey, United States of America., Devenport D; Dept. of Molecular Biology Princeton University, Princeton, New Jersey, United States of America., Mlodzik M; Dept. of Cell, Developmental, & Regenerative Biology,Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.

Publikováno v: PLoS genetics [PLoS Genet] 2023 Jul 18; Vol. 19 (7), pp. e1010849. Date of Electronic Publication: 2023 Jul 18 (Print Publication: 2023).