Structural basis of ligand binding modes at the neuropeptide Y Y 1 receptor.

Autor: Yang Z; Chinese Academy of Sciences Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China., Han S; Chinese Academy of Sciences Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China., Keller M; Pharmaceutical/Medicinal Chemistry II, Institute of Pharmacy, University of Regensburg, Regensburg, Germany. max.keller@chemie.uni-regensburg.de., Kaiser A; Institute of Biochemistry, Faculty of Life Sciences, Leipzig University, Leipzig, Germany., Bender BJ; Department of Pharmacology, Center for Structural Biology, Vanderbilt University, Nashville, TN, USA., Bosse M; Institute for Medical Physics and Biophysics, Leipzig University, Leipzig, Germany., Burkert K; Institute of Biochemistry, Faculty of Life Sciences, Leipzig University, Leipzig, Germany., Kögler LM; Institute of Biochemistry, Faculty of Life Sciences, Leipzig University, Leipzig, Germany., Wifling D; Pharmaceutical/Medicinal Chemistry II, Institute of Pharmacy, University of Regensburg, Regensburg, Germany., Bernhardt G; Pharmaceutical/Medicinal Chemistry II, Institute of Pharmacy, University of Regensburg, Regensburg, Germany., Plank N; Pharmaceutical/Medicinal Chemistry II, Institute of Pharmacy, University of Regensburg, Regensburg, Germany., Littmann T; Pharmaceutical/Medicinal Chemistry II, Institute of Pharmacy, University of Regensburg, Regensburg, Germany., Schmidt P; Institute for Medical Physics and Biophysics, Leipzig University, Leipzig, Germany., Yi C; Chinese Academy of Sciences Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China., Li B; Chinese Academy of Sciences Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China., Ye S; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China., Zhang R; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.; National Center for Protein Science Shanghai, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China., Xu B; Department of Neuroscience, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Larhammar D; Department of Neuroscience, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Stevens RC; iHuman Institute, ShanghaiTech University, Shanghai, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai, China., Huster D; Institute for Medical Physics and Biophysics, Leipzig University, Leipzig, Germany., Meiler J; Department of Pharmacology, Center for Structural Biology, Vanderbilt University, Nashville, TN, USA.; Departments of Chemistry and Bioinformatics, Center for Structural Biology, Vanderbilt University, Nashville, TN, USA., Zhao Q; Chinese Academy of Sciences Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.; Chinese Academy of Sciences Center for Excellence in Biomacromolecules, Chinese Academy of Sciences, Beijing, China., Beck-Sickinger AG; Institute of Biochemistry, Faculty of Life Sciences, Leipzig University, Leipzig, Germany. abeck-sickinger@uni-leipzig.de., Buschauer A; Pharmaceutical/Medicinal Chemistry II, Institute of Pharmacy, University of Regensburg, Regensburg, Germany., Wu B; Chinese Academy of Sciences Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. beiliwu@simm.ac.cn.; University of Chinese Academy of Sciences, Beijing, China. beiliwu@simm.ac.cn.; School of Life Science and Technology, ShanghaiTech University, Shanghai, China. beiliwu@simm.ac.cn.; Chinese Academy of Sciences Center for Excellence in Biomacromolecules, Chinese Academy of Sciences, Beijing, China. beiliwu@simm.ac.cn.

Publikováno v: Nature [Nature] 2018 Apr; Vol. 556 (7702), pp. 520-524. Date of Electronic Publication: 2018 Apr 18.

Condensed bridgehead nitrogen heterocyclic system: synthesis and pharmacological activities of 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole derivatives of ibuprofen and biphenyl-4-yloxy acetic acid.

Autor: Amir M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, New Delhi 110 062, India. mamir_s2003@yahoo.co.in, Kumar H, Javed SA

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2008 Oct; Vol. 43 (10), pp. 2056-66. Date of Electronic Publication: 2007 Oct 06.

Inhalation by design: novel tertiary amine muscarinic M₃ receptor antagonists with slow off-rate binding kinetics for inhaled once-daily treatment of chronic obstructive pulmonary disease.

Autor: Glossop PA; Department of Worldwide Medicinal Chemistry, Pfizer Global Research and Development, Sandwich Laboratories, Ramsgate Road, Kent CT13 9NJ, U.K. paglossop@gmail.com, Watson CA, Price DA, Bunnage ME, Middleton DS, Wood A, James K, Roberts D, Strang RS, Yeadon M, Perros-Huguet C, Clarke NP, Trevethick MA, Machin I, Stuart EF, Evans SM, Harrison AC, Fairman DA, Agoram B, Burrows JL, Feeder N, Fulton CK, Dillon BR, Entwistle DA, Spence FJ

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2011 Oct 13; Vol. 54 (19), pp. 6888-904. Date of Electronic Publication: 2011 Sep 20.

Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors.

Autor: Tessier P; MethylGene Inc., Department of Medicinal Chemistry, 7220 Frederick-Banting, Montréal, Québec, Canada H4S 2A1., Smil DV, Wahhab A, Leit S, Rahil J, Li Z, Déziel R, Besterman JM

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2009 Oct 01; Vol. 19 (19), pp. 5684-8. Date of Electronic Publication: 2009 Aug 07.

Cardiovascular effects of a proprietary l-methadone/fenpipramide combination (Polamivet) alone and in addition to acepromazine in healthy Beagle dogs.

Autor: Tünsmeyer J; Small Animal Clinic, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany. julia.tuensmeyer@tiho-hannover.de, Vaske B, Bösing B, Kästner SB

Publikováno v: Veterinary anaesthesia and analgesia [Vet Anaesth Analg] 2012 Sep; Vol. 39 (5), pp. 451-63. Date of Electronic Publication: 2012 Jul 13.