Výsledky vyhledávání - "dimerization inhibitors"

Akademický článek

Small Molecule–Peptide Conjugates as Dimerization Inhibitors of Leishmania infantum Trypanothione Disulfide Reductase

Autor: Alejandro Revuelto, Isabel López-Martín, Héctor de Lucio, Juan Carlos García-Soriano, Nicola Zanda, Sonia de Castro, Federico Gago, Antonio Jiménez-Ruiz, Sonsoles Velázquez, María-José Camarasa

Publikováno v: Pharmaceuticals, Vol 14, Iss 7, p 689 (2021)

Trypanothione disulfide reductase (TryR) is an essential homodimeric enzyme of trypanosomatid parasites that has been validated as a drug target to fight human infections. Using peptides and peptidomimetics, we previously obtained proof of concept th

Externí odkaz: https://doaj.org/article/ae16e1932b9142b884536d0bb5ad011f

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Akademický článek

An Atomic-Level Perspective of HMG-CoA-Reductase: The Target Enzyme to Treat Hypercholesterolemia

Autor: Diana S. Gesto, Carlos M. S. Pereira, Nuno M. F. S. Cerqueira, Sérgio F. Sousa

Publikováno v: Molecules, Vol 25, Iss 17, p 3891 (2020)

This review provides an updated atomic-level perspective regarding the enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoAR), linking the more recent data on this enzyme with a structure/function interpretation. This enzyme catalyzes one

Externí odkaz: https://doaj.org/article/3e60b7dbee53428da7e73e9e03849fcf

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Small Molecule–Peptide Conjugates as Dimerization Inhibitors of Leishmania infantum Trypanothione Disulfide Reductase

Autor: Nicola Zanda, Sonia de Castro, Juan Carlos García-Soriano, Antonio Jiménez-Ruiz, Héctor de Lucio, Federico Gago, Alejandro Revuelto, María-José Camarasa, Isabel López-Martín, Sonsoles Velázquez

Publikováno v: Pharmaceuticals
Volume 14
Issue 7
Pharmaceuticals, Vol 14, Iss 689, p 689 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33a9ce634fa455ae08cf88bb33627385

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An atomic-level perspective of HMG-CoA-reductase: The target enzyme to treat hypercholesterolemia

Autor: Gesto, Diana S., Pereira, Carlos M. S., Cerqueira, Nuno M. F. S., Sousa, Sérgio F.

UIDB/04378/2020 PTDC/QUI-QFI/31689/2017 This review provides an updated atomic-level perspective regarding the enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoAR), linking the more recent data on this enzyme with a structure/function in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1437::0787d172617590f6f5ee33f2875e7f99
https://hdl.handle.net/10362/120974

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Akademický článek

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Akademický článek

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Alkyl hydroxybenzoic acid derivatives that inhibit HIV-1 protease dimerization

Autor: Vanderlan da Silva Bolzani, Michèle Reboud-Ravaux, Dulce Helena Siqueira Silva, Laure Dufau, Maicon Segalla Petrônio, Luis Octávio Regasini, Otavio Flausino, Thierry Rose

Publikováno v: Current Medicinal Chemistry
Current Medicinal Chemistry, 2012, 19 (26), pp.4534-4540. ⟨10.2174/092986712803251557⟩
Current Medicinal Chemistry, Bentham Science Publishers, 2012, 19 (26), pp.4534-4540. ⟨10.2174/092986712803251557⟩
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International audience; The therapeutic potential of gallic acid and its derivatives as anti-cancer, antimicrobial and antiviral agents is well known. We have examined the mechanism by which natural gallic acid and newly synthesized gallic acid alkyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28e5d588e20746ddc89412f8757340ff
https://pubmed.ncbi.nlm.nih.gov/22963666

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