Výsledky vyhledávání - "dihydroxyethylene isosters"

Synthesis and Biological Activity of Potent HIV-1 Protease Inhibitors Based on Phe-Pro Dihydroxyethylene Isosteres

Autor: Alessandro Tossi, Petia Genova, Federico Berti, Pietro Campaner, Fabio Benedetti, Francesca Dinon, Anton Hinkov, Sara Budal, Radka Argirova, Vasil Atanassov

Publikováno v: Journal of Medicinal Chemistry. 55:3900-3910

Peptidomimetic inhibitors of HIV-1 PR are still a key resource in the fight against AIDS. Here we describe the synthesis and biological activity of HIV-1 PR inhibitors based on four novel dihydroxyethylene isosteres of the Phe-Pro and Pro- Pro dipept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::772e2e15d6980b4454241b94655d4a6f
https://doi.org/10.1021/jm3001136

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Inibitori peptidomimetici di HIV-PR basati su isosteri diamminodiolici del dipeptide Phe-Pro

Autor: Benedetti, Fabio, Berti, Federico, Campaner, Pietro, Dinon, Francesca, Tossi, Alessandro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0a30127ada73f6743427f3b10c6da42f
https://hdl.handle.net/11368/1684640

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Epoxyalcohol route to hydroxyethylene dipeptide isosteres. Stereodivergent synthesis of the diamino alcohol core of ritonavir and its C-2 epimer

Autor: Fabio Benedetti, Stefano Norbedo, Federico Berti

Publikováno v: The Journal of organic chemistry. 67(24)

A stereoselective synthesis of hydroxyethylene dipeptide isosteres based on the 1,4-diamino-2-hydroxybutane structure is described. Horner-Emmons olefination of phosphonates derived from alpha-amino acids, stereoselective reduction of the resulting e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0978600a01cc0ee477b4d5d13d585a33
https://pubmed.ncbi.nlm.nih.gov/12444650

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