Zobrazeno 1 - 10
of 278
pro vyhledávání: '"digital spatial profiling"'
Autor:
Victoria Bingham, Louise Harewood, Stephen McQuaid, Stephanie G. Craig, Julia F. Revolta, Chang S. Kim, Shambhavi Srivastava, Javier Quezada-Marín, Matthew P. Humphries, Manuel Salto-Tellez
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal human malignancies. Tissue microarrays (TMA) are an established method of high throughput biomarker interrogation in tissues but may not capture histological features of
Externí odkaz:
https://doaj.org/article/d25a41f56be2446d9bbeea882fd613c5
Autor:
Mark B. Wiley, Jessica Bauer, Valentina Alvarez, Kunaal Mehrotra, Wenxuan Cheng, Zoe Kolics, Michael Giarrizzo, Komala Ingle, Agnieszka B. Bialkowska, Barbara Jung
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Acute Pancreatitis (AP) is associated with high mortality and current treatment options are limited to supportive care. We found that blockade of activin A (activin) in mice improves outcomes in two murine models of AP. To test the hypothesi
Externí odkaz:
https://doaj.org/article/a7d303b3264a468a9a6c0e386cd0a69d
Autor:
Tim Bathe, Gabriela P. Hery, Jonathan A. B. Villareal, Jennifer L. Phillips, Eric M. Cohen, Rohan V. Sharma, Wangchen Tsering, Stefan Prokop
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-25 (2024)
Abstract The disease-specific accumulation of pathological proteins has long been the major focus of research in neurodegenerative diseases (ND), including Alzheimer’s disease (AD) and related dementias (RD), but the recent identification of a mult
Externí odkaz:
https://doaj.org/article/12cef3313feb4dd79e438d8394192c0c
Autor:
Jill M. Brooks, Yuanning Zheng, Kelly Hunter, Benjamin E. Willcox, Janet Dunn, Paul Nankivell, Olivier Gevaert, Hisham Mehanna
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundThe incidence of oropharyngeal cancer (OPC) is increasing, due mainly to a rise in Human Papilloma Virus (HPV)-mediated disease. HPV-mediated OPC has significantly better prognosis compared with HPV-negative OPC, stimulating interest in tre
Externí odkaz:
https://doaj.org/article/f12a3ff832bb48f7a7eb35b9911523e9
Autor:
S. Böning, F. Schneider, A.-K. Huber, D. Langhoff, H. Lin, A. Kaczorowski, A. Stenzinger, M. Hohenfellner, S. Duensing, A. Duensing
Publikováno v:
Immuno-Oncology and Technology, Vol 23, Iss , Pp 100727- (2024)
Background: Spatial biology is an emerging concept to interrogate tumor heterogeneity. The NanoString GeoMx® Digital Spatial Profiling (DSP) platform has become increasingly available. It combines high-plex analysis of protein or messenger RNA expre
Externí odkaz:
https://doaj.org/article/ed80adec76e24926bc48da86a8414767
Autor:
Zicheng Zhang, Xujie Sun, Yutao Liu, Yibo Zhang, Zijian Yang, Jiyan Dong, Nan Wang, Jianming Ying, Meng Zhou, Lin Yang
Publikováno v:
Advanced Science, Vol 11, Iss 31, Pp n/a-n/a (2024)
Abstract Small cell lung cancer (SCLC) is a highly aggressive malignancy characterized by rapid growth and early metastasis and is susceptible to treatment resistance and recurrence. Understanding the intra‐tumoral spatial heterogeneity in SCLC is
Externí odkaz:
https://doaj.org/article/93e0d99e563f43319be331130ef22947
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 10, Iss 4, Pp n/a-n/a (2024)
Abstract Gastric poorly cohesive carcinoma (PCC) manifests with a diffuse pattern and diverse tumor cell morphologies, often indicating a more unfavorable prognosis. Recent consensus has reclassified PCC based on the proportion of signet‐ring cells
Externí odkaz:
https://doaj.org/article/1a58e37629db423f918ea3f73c647efb
Autor:
William P. Duggan, Batuhan Kisakol, Ina Woods, Mohammedreza Azimi, Heiko Dussmann, Joanna Fay, Tony O’Grady, Barry Maguire, Ian S. Reynolds, Manuela Salvucci, Daniel J. Slade, Deborah A. McNamara, John P. Burke, Jochen H.M. Prehn
Publikováno v:
Gut Microbes, Vol 16, Iss 1 (2024)
ABSTRACTMucinous colorectal cancer (CRC) is a common histological subtype of colorectal adenocarcinoma, associated with a poor response to chemoradiotherapy. The commensal facultative anaerobes fusobacteria, have been associated with poor prognosis s
Externí odkaz:
https://doaj.org/article/2b11e6dc763e4a1aacdfb8cd8e2a82f3
Publikováno v:
Immuno-Oncology and Technology, Vol 21, Iss , Pp 100690- (2024)
Background: Clear-cell renal cell carcinoma (ccRCC) is the most common and aggressive form of renal cancer and a paradigm of inter- and intratumor heterogeneity. We carried out an exploratory digital spatial profiling of the tumor interior and periph
Externí odkaz:
https://doaj.org/article/c1691d05fa1843ee8916eef333910c7f
Autor:
Vahid Yaghoubi Naei, James Monkman, Habib Sadeghirad, Ahmed Mehdi, Tony Blick, William Mullally, Ken O'Byrne, Majid Ebrahimi Warkiani, Arutha Kulasinghe
Publikováno v:
Clinical & Translational Immunology, Vol 13, Iss 7, Pp n/a-n/a (2024)
Abstract Objectives Non‐small‐cell lung carcinoma (NSCLC) is the most prevalent and lethal form of lung cancer. The need for biomarker‐informed stratification of targeted therapies has underpinned the need to uncover the underlying properties o
Externí odkaz:
https://doaj.org/article/71afaa1369b246e48af2b950a8616b55