Zobrazeno 1 - 10
of 127
pro vyhledávání: '"differentiation trajectory"'
Autor:
Yuhan Tian, Xia Wu, Songhao Luo, Dan Xiong, Rong Liu, Lanqi Hu, Yuchen Yuan, Guowei Shi, Junjie Yao, Zhiwei Huang, Fang Fu, Xin Yang, Zhonghui Tang, Jiajun Zhang, Kunhua Hu
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 2173-2189 (2024)
The vast neuronal diversity in the human neocortex is vital for high-order brain functions, necessitating elucidation of the regulatory mechanisms underlying such unparalleled diversity. However, recent studies have yet to comprehensively reveal the
Externí odkaz:
https://doaj.org/article/73c7f4a2770f448ba2736defc3f3527e
Autor:
Junxuan Peng, Shengda Cao, Zhen Hu, Jiayi Zhu, Yi Zhu, Xiaole Sheng, Zuchao Cai, Rongpan Bai, Xushen Xiong, Jinghao Sheng
Publikováno v:
Environment International, Vol 191, Iss , Pp 108948- (2024)
Bisphenol A (BPA) and its substitute fluorene-9-bisphenol (BHPF) are used in consumer products; however, their toxic effects on intestinal epithelium remain largely unknown. In this study, we combined intestinal organoids and single-cell RNA sequenci
Externí odkaz:
https://doaj.org/article/9c16797344c44056b0d5ac1e2b937b68
Publikováno v:
BMC Medical Genomics, Vol 17, Iss 1, Pp 1-19 (2024)
Abstract Background Hepatocellular carcinoma represents a significant global burden in terms of cancer-related mortality, posing a substantial risk to human health. Despite the availability of various treatment modalities, the overall survival rates
Externí odkaz:
https://doaj.org/article/85898c8aed49496d8999f94d170582ee
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract It has been found that progression from leukoplakia to head and neck squamous cell carcinoma (HNSCC) is a long-term process that may involve changes in the multicellular ecosystem. We acquired scRNA-seq samples information from gene expressi
Externí odkaz:
https://doaj.org/article/2dc45ed8f2d44785944191b89f4ee33f
Publikováno v:
BMC Cardiovascular Disorders, Vol 24, Iss 1, Pp 1-9 (2024)
Abstract Objective We aimed to explore the heterogeneity of neurons in heart failure with dilated cardiomyopathy (DCM). Methods Single-cell RNA sequencing (scRNA-seq) data of patients with DCM and chronic heart failure and healthy samples from GSE183
Externí odkaz:
https://doaj.org/article/9f75f0f949cb4ac683a73e359d402f8a
Autor:
Qiu Jun, Wang Haoyun, Lv Xin, Mao Lipeng, Huang Junyan, Hao Tao, Li Junliang, Qi Shuo, Chen Guodong, Jiang Haiping
Publikováno v:
Open Life Sciences, Vol 18, Iss 1, Pp 589-604 (2023)
The aim of this study is to explore a novel classification and investigate the clinical significance of hepatocellular carcinoma (HCC) cells. We analyzed integrated single-cell RNA sequencing and bulk RNA-seq data obtained from HCC samples. Cell traj
Externí odkaz:
https://doaj.org/article/191d8984bf7a460a9db00132b6931d0f
Publikováno v:
Jisuanji kexue yu tansuo, Vol 17, Iss 7, Pp 1609-1621 (2023)
The construction of cell differentiation trajectories from single-cell transcriptomic data or proteomic data by single-cell trajectory inference methods can help to understand the developmental process of normal tissues or provide pathologically rele
Externí odkaz:
https://doaj.org/article/2b60d49c61194f568ca52a7ec320e7a7
Publikováno v:
Open Life Sciences, Vol 18, Iss 1, Pp 860-7 (2023)
Bilateral renal clear cell carcinoma (BRCC) is a rare type of renal cell carcinoma (RCC) that accounts for only 1–5% of RCC cases and has a poor clinical prognosis. The origin, tumor microenvironment, cellular molecular features, and intra-tumoral
Externí odkaz:
https://doaj.org/article/aa97c02919684938b3e338179b26c746
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Ovarian cancer is a heterogeneous disease with different molecular phenotypes. We performed molecular typing of ovarian cancer using cell differentiation trajectory analysis and proposed a prognostic risk scoring model. Using the copy number variatio
Externí odkaz:
https://doaj.org/article/f97ac0800f56443d8c4cb7a04b2d2553
Publikováno v:
Journal of Ovarian Research, Vol 16, Iss 1, Pp 1-18 (2023)
Abstract Ovarian cancer is a highly heterogeneous gynecological malignancy that seriously affects the survival and prognosis of female patients. Single-cell sequencing and transcriptome analysis can effectively characterize tumor heterogeneity to bet
Externí odkaz:
https://doaj.org/article/74cb87ab157a4681a7c0b6d9cd5e1ae0