Zobrazeno 1 - 10
of 2 297
pro vyhledávání: '"differentiation therapy"'
Autor:
Wei Zhang, Xianhui Ruan, Yue Huang, Weiyu Zhang, Guangwei Xu, Jingzhu Zhao, Jie Hao, Nan Qin, Jinjian Liu, Qian Su, Jianfeng Liu, Mei Tao, Yuqi Wang, Songfeng Wei, Xiangqian Zheng, Ming Gao
Publikováno v:
Advanced Science, Vol 11, Iss 32, Pp n/a-n/a (2024)
Abstract Thyroid cancer is the most common type of endocrine cancer, and most patients have a good prognosis. However, the thyroid cancer differentiation status strongly affects patient response to conventional treatment and prognosis. Therefore, exp
Externí odkaz:
https://doaj.org/article/c341cffecf914f6ea73ee505e93c08f7
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-23 (2024)
Abstract All-trans retinoic acid (ATRA) is the most relevant and functionally active metabolite of Vitamin-A. From a therapeutic standpoint, ATRA is the first example of pharmacological agent exerting its anti-tumor activity via a cell differentiatin
Externí odkaz:
https://doaj.org/article/b2f3bf0f31de440d8e1ace0368e9d1b0
Autor:
Varvara Kolesnikova, Alexander Revishchin, Lika Fab, Anna Alekseeva, Anastasia Ryabova, Igor Pronin, Dmitry Y. Usachev, Alexey Kopylov, Galina Pavlova
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Current therapy protocols fail to cure high-grade gliomas and prevent recurrence. Therefore, novel approaches need to be developed. A re-programing of glioma cell fate is an alternative attractive way to stop tumor growth. The two-step protocol appli
Externí odkaz:
https://doaj.org/article/2c76eb8de8804426b451aec90f01153d
Autor:
Daniela Magliulo, Matilde Simoni, Carolina Caserta, Cristina Fracassi, Serena Belluschi, Kety Giannetti, Raffaella Pini, Ettore Zapparoli, Stefano Beretta, Martina Uggè, Eleonora Draghi, Federico Rossari, Nadia Coltella, Cristina Tresoldi, Marco J Morelli, Raffaella Di Micco, Bernhard Gentner, Luca Vago, Rosa Bernardi
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 11, Pp 1-19 (2023)
Abstract One of the defining features of acute myeloid leukemia (AML) is an arrest of myeloid differentiation whose molecular determinants are still poorly defined. Pharmacological removal of the differentiation block contributes to the cure of acute
Externí odkaz:
https://doaj.org/article/2d1702404ed248f580d807aa7c1fabee
Autor:
Eleanor O’Brien, Carmen Tse, Ian Tracy, Ian Reddin, Joanna Selfe, Jane Gibson, William Tapper, Reuben J. Pengelly, Jinhui Gao, Ewa Aladowicz, Gemma Petts, Khin Thway, Sergey Popov, Anna Kelsey, Timothy J. Underwood, Janet Shipley, Zoë S. Walters
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-16 (2023)
Abstract Background Rhabdomyosarcomas (RMS) are predominantly paediatric sarcomas thought to originate from muscle precursor cells due to impaired myogenic differentiation. Despite intensive treatment, 5-year survival for patients with advanced disea
Externí odkaz:
https://doaj.org/article/b09403c2536c486da89cc39dfaf84132
Autor:
Myoteri, D.1 dmyoteri@gmail.com, Dellaportas, D.2, Tsavari, A.1, Tsagkaroulaki, L.3, Moschouris, H.4, Kamperos, A.3, Zizi-Sermpetzoglou, A.1
Publikováno v:
Scientific Chronicles / Epistimonika Chronika. 2016, Vol. 21 Issue 1, p97-103. 7p.
Autor:
Zheng, Ruifang1 (AUTHOR), Studzinski, George P.1 (AUTHOR) studzins@njms.rutgers.edu
Publikováno v:
Leukemia & Lymphoma. Jun2017, Vol. 58 Issue 6, p1468-1480. 13p.
Autor:
Gasch, Claudia1,2, Ffrench, Brendan1,2, O'Leary, John J.1,2, Gallagher, Michael F.1,2 gallagmi@tcd.ie
Publikováno v:
Molecular Cancer. 2/23/2017, Vol. 16, p1-15. 15p. 2 Diagrams.
Autor:
Rakefet Ben-Yishay, Opher Globus, Nora Balint-Lahat, Sheli Arbili-Yarhi, Neta Bar-Hai, Vered Bar, Sara Aharon, Anna Kosenko, Adi Zundelevich, Raanan Berger, Dana Ishay-Ronen
Publikováno v:
Cells, Vol 13, Iss 17, p 1506 (2024)
Epithelial-to-mesenchymal transition (EMT) plays a major role in breast cancer progression and the development of drug resistance. We have previously demonstrated a trans-differentiation therapeutic approach targeting invasive dedifferentiated cancer
Externí odkaz:
https://doaj.org/article/c330496992df471197afa20b6a4dc4ea
Autor:
Jie Lei, Yujia Pan, Rui Gao, Bin He, Zifeng Wang, Xinxing Lei, Zijian Zhang, Na Yang, Min Yan
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-19 (2023)
Abstract Background Triple-negative breast cancer (TNBC) is one of the most aggressive human cancers and has poor prognosis. Approximately 80% of TNBC cases belong to the molecular basal-like subtype, which can be exploited therapeutically by inducin
Externí odkaz:
https://doaj.org/article/27f85126c65746f5859e00bfdc93205b