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Aspartic protease inhibitors. An integrated approach for the design and synthesis of diaminodiol-based peptidomimetics

Autor: Anil C. Nair, Nikolinka Antcheva, Irena Bonin, Alessandro Tossi, Domenico Romeo, Fabio Benedetti, Giorgio Palù, Stefano Norbedo, Stanislav Miertus, Federico Dal Bello, Tibor Maliar

Aspartic proteases play key roles in a variety of pathologies, including acquired immunodeficiency syndrome. Peptidomimetic inhibitors can act as drugs to combat these pathologies. We have developed an integrated methodology for preparing human immun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::712f9f4f4a7f2a9ffd14aadecc38b4a7
http://hdl.handle.net/11577/1360624

Aspartic protease inhibitors. An integrated approach for the design andsynthesis of diaminodiol-based peptidomimetics.

Autor: Tossi A; Department of Biochemistry, Biophysics and Macromolecular Chemistry, University of Trieste, Italy. tossi@bbcm.univ.trieste.it, Bonin I, Antcheva N, Norbedo S, Benedetti F, Miertus S, Nair AC, Maliar T, Dal Bello F, Palù G, Romeo D

Publikováno v: European journal of biochemistry [Eur J Biochem] 2000 Mar; Vol. 267 (6), pp. 1715-22.

Synthesis and Biological Activity of Potent HIV-1 Protease Inhibitors Based on Phe-Pro Dihydroxyethylene Isosteres

Autor: Alessandro Tossi, Petia Genova, Federico Berti, Pietro Campaner, Fabio Benedetti, Francesca Dinon, Anton Hinkov, Sara Budal, Radka Argirova, Vasil Atanassov

Publikováno v: Journal of Medicinal Chemistry. 55:3900-3910

Peptidomimetic inhibitors of HIV-1 PR are still a key resource in the fight against AIDS. Here we describe the synthesis and biological activity of HIV-1 PR inhibitors based on four novel dihydroxyethylene isosteres of the Phe-Pro and Pro- Pro dipept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::772e2e15d6980b4454241b94655d4a6f
https://doi.org/10.1021/jm3001136