Zobrazeno 1 - 8 of 8 pro vyhledávání: '"diagnostic imaging [Plaque, Amyloid]"'
1
Association of PET-based stages of amyloid deposition with neuropathological markers of Aβ pathology
Autor: Teipel, Stefan, Temp, Anna Gesine Marie, Levin, Fedor, Dyrba, Martin, Grothe, Michel, Initiative, Alzheimer's Disease Neuroimaging
Publikováno v: Annals of Clinical and Translational Neurology 8(1), 29-42 (2021). doi:10.1002/acn3.51238
Annals of Clinical and Translational Neurology
Objective To determine if PET‐based stages of regional amyloid deposition are associated with neuropathological phases of Aβ pathology. Methods We applied data‐driven regional frequency‐based and a‐priori striatum‐based PET staging approac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1f072a19cbe0e569dede7a8185b39e03
https://pub.dzne.de/record/154235
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2
Asymmetry of Fibrillar Plaque Burden in Amyloid Mouse Models
Autor: Christian Haass, Barbara von Ungern-Sternberg, Karlheinz Baumann, Florian Eckenweber, Sabina Tahirovic, Samira Parhizkar, Tanja Blume, Matthias Brendel, Franz-Josef Gildehaus, Michael Willem, Christian Sacher, Peter Bartenstein, Gloria Biechele, Carola Focke, Jochen Herms, Maximilian Deussing, Axel Rominger, Leonie Beyer, Gernot Kleinberger, Julia Sauerbeck, Paul Cumming, Simon Lindner
Publikováno v: Journal of nuclear medicine 61(12), 1825-1831 (2020). doi:10.2967/jnumed.120.242750
Asymmetries of amyloid-β (Aβ) burden are well known in Alzheimer disease (AD) but did not receive attention in Aβ mouse models of Alzheimer disease. Therefore, we investigated Aβ asymmetries in Aβ mouse models examined by Aβ small-animal PET an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdcad1b2fbac716bd6219397b87226cc
https://pubmed.ncbi.nlm.nih.gov/32414948
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3
Ultra-High Field MRI in Alzheimer’s Disease: Effective Transverse Relaxation Rate and Quantitative Susceptibility Mapping of Human Brain In Vivo and Ex Vivo compared to Histology
Autor: Manuela Neumann, Dávid Z. Balla, Rolf Pohmann, Gisela E. Hagberg, Klaus Scheffler, Christoph Laske, Joana Loureiro, Oliver Preische, E Tuzzi
Publikováno v: Journal of Alzheimer's disease 73(4), 1481-1499 (2020). doi:10.3233/JAD-190424
Journal of Alzheimer's Disease
Alzheimer's disease (AD) is the most common cause of dementia worldwide. So far, diagnosis of AD is only unequivocally defined through postmortem histology. Amyloid plaques are a classical hallmark of AD and amyloid load is currently quantified by Po
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81318a8936e0e9735ba48dfa79884a20
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4
Assessment of Tau Tangles and Amyloid-β Plaques Among Super Agers Using PET Imaging
Autor: Merle C Hoenig, Niclas Willscheid, Gérard N. Bischof, Alexander Drzezga, Thilo van Eimeren, Alzheimer’s Disease Neuroimaging Initiative
Publikováno v: JAMA network open 3(12), e2028337 (2020). doi:10.1001/jamanetworkopen.2020.28337
JAMA Network Open
JAMA network open 3(12), e2028337-(2020). doi:10.1001/jamanetworkopen.2020.28337
This cross-sectional study examines positron emission tomography (PET) imaging to investigate the burden of tau tangles and amyloid β plaques in super agers, normal agers, and patients with mild cognitive impairment vs younger amyloid-negative contr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c054599096dbbab9620d931e551a8a9b
https://doi.org/10.1001/jamanetworkopen.2020.28337
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5
Development of Alzheimer-disease neuroimaging-biomarkers using mouse models with amyloid-precursor protein-transgene expression
Autor: Stefan J. Teipel, Johannes Thome, Ralph Buchert, Jens Pahnke, Harald Hampel
Publikováno v: Progress in neurobiology 95(4), 547-556 (2011). doi:10.1016/j.pneurobio.2011.05.004
There are important recent developments in Alzheimer's disease (AD) translational research, especially with respect to the imaging of amyloid pathology in vivo using MRI and PET technologies. Here we exploit the most widely used transgenic mouse mode
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::349dcabbb902d6146ef5838ba24050b5
https://doi.org/10.1016/j.pneurobio.2011.05.004
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6
Cross-Sectional Comparison of Small Animal [18F]-Florbetaben Amyloid-PET between Transgenic AD Mouse Models
Autor: Steffen Burgold, Paul Cumming, Harald Steiner, Jochen Herms, Christian Haass, Karlheinz Baumann, Matthias Brendel, Franz-Josef Gildehaus, Axel Rominger, Janette Carlsen, Anna Jaworska, Peter Bartenstein, Eric Grießinger, Christina Rötzer
Publikováno v: PLOS ONE 10(2), e0116678 (2015). doi:10.1371/journal.pone.0116678
PLoS ONE, Vol 10, Iss 2, p e0116678 (2015)
PLoS ONE
We aimed to compare [18F]-florbetaben PET imaging in four transgenic mouse strains modelling Alzheimer’s disease (AD), with the main focus on APPswe/PS2 mice and C57Bl/6 mice serving as controls (WT). A consistent PET protocol (N = 82 PET scans) wa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e29e7f83308a4f726b0cc06d2e9312c
https://opus4.kobv.de/opus4-fau/frontdoor/index/index/docId/6034
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7
Amyloid-PET predicts inhibition of de novo plaque formation upon chronic γ-secretase modulator treatment
Autor: Franz-Josef Gildehaus, Matthias Brendel, Janette Carlsen, Anna Jaworska, Peter Bartenstein, Christian Haass, Christina Rötzer, Thomas Luebbers, Johannes Trambauer, Harald Steiner, Johan Bylund, Paul Cumming, Karlheinz Baumann, Jochen Herms, Axel Rominger
Publikováno v: Molecular psychiatry 20(10), 1179-1187 (2015). doi:10.1038/mp.2015.74
Molecular Psychiatry
In a positron-emission tomography (PET) study with the β-amyloid (Aβ) tracer [(18)F]-florbetaben, we previously showed that Aβ deposition in transgenic mice expressing Swedish mutant APP (APP-Swe) mice can be tracked in vivo. γ-Secretase modulato
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a856cd45d5200ce586d07ac7fc141153
https://pub.dzne.de/record/138131
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8
Longitudinal PET-MRI reveals β-amyloid deposition and rCBF dynamics and connects vascular amyloidosis to quantitative loss of perfusion
Autor: Chommanad Lerdkrai, Mathias Jucker, Carsten Calaminus, Hans F. Wehrl, Andreas Schmid, Detlef Stiller, Lan Ye, Gerald Reischl, Olga Garaschuk, Mathias Staufenbiel, Stefan Wiehr, Julia G. Mannheim, Anke Stahlschmidt, Osama Sabri, Bernd J. Pichler, Florian C. Maier, Michael Burnet
Publikováno v: Nature medicine 20(12), 1485-1492 (2014). doi:10.1038/nm.3734
The dynamics of β-amyloid deposition and related second-order physiological effects, such as regional cerebral blood flow (rCBF), are key factors for a deeper understanding of Alzheimer's disease (AD). We present longitudinal in vivo data on the dyn
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69842385ff2286b45170aeb00442079d
https://pubmed.ncbi.nlm.nih.gov/25384087
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