Zobrazeno 1 - 10
of 21
pro vyhledávání: '"diagnostic imaging [Neurodegenerative Diseases]"'
Autor:
Minoshima, Satoshi, Cross, Donna, Thientunyakit, Tanyaluck, Foster, Norman L., Drzezga, Alexander
Publikováno v:
Journal of nuclear medicine 63(Suppl 1), 2S-12S (2022). doi:10.2967/jnumed.121.263194
Journal of nuclear medicine 63(Supplement 1), 2S-12S (2022). doi:10.2967/jnumed.121.263194
Journal of nuclear medicine 63(Supplement 1), 2S-12S (2022). doi:10.2967/jnumed.121.263194
Since the invention of 18F-FDG as a neurochemical tracer in the 1970s, 18F-FDG PET has been used extensively for dementia research and clinical applications. FDG, a glucose analog, is transported into the brain via glucose transporters and metabolize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e5bfb26a14127cc527b3ad8e8853541
https://doi.org/10.2967/jnumed.121.263194
https://doi.org/10.2967/jnumed.121.263194
Autor:
Katzdobler, Sabrina, Nitschmann, Alexander, Nack, Anne, Fietzek, Urban, Kurz, Carolin, Häckert, Jan, Stapf, Theresa, Ferschmann, Christian, Scheifele, Heinrich Maximilian, Eckenweber, Florian, Biechele, Gloria, Franzmeier, Nicolai, Barthel, Henryk, Dewenter, Anna, Schönecker, Sonja, Saur, Dorothee, Schroeter, Matthias L, Rumpf, Jost-Julian, Rullmann, Michael, Schildan, Andreas, Patt, Marianne, Stephens, Andrew W, van Eimeren, Thilo, Bischof, Gerard, Neumaier, Bernd, Drzezga, Alexander, Danek, Adrian, Classen, Joseph, Bürger, Katharina, Janowitz, Daniel, Rauchmann, Boris Stephan, Stöcklein, Sophia, Perneczky, Robert, Schöberl, Florian, Beyer, Leonie, Zwergal, Andreas, Höglinger, Günter U, Bartenstein, Peter, Villemagne, Victor, Seibyl, John, Sabri, Osama, Levin, Johannes, Brendel, Matthias, Tauopathies, German Imaging Initiative for, Marek, Ken, Song, Mengmeng, Wagemann, Olivia, Palleis, Carla, Weidinger, Endy
Publikováno v:
European journal of nuclear medicine and molecular imaging 50(2), 423-434 (2023). doi:10.1007/s00259-022-05964-w
European Journal of Nuclear Medicine and Molecular Imaging
European Journal of Nuclear Medicine and Molecular Imaging
Purpose Early after [18F]PI-2620 PET tracer administration, perfusion imaging has potential for regional assessment of neuronal injury in neurodegenerative diseases. This is while standard late-phase [18F]PI-2620 tau-PET is able to discriminate the 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::444aaa06df012997249a3b4b760f94a4
https://pub.dzne.de/record/165243
https://pub.dzne.de/record/165243
Publikováno v:
Journal of nuclear medicine 63(Supplement 1), 68S-74S (2022). doi:10.2967/jnumed.121.263202
Journal of nuclear medicine 63(Suppl 1), 68S-74S (2022). doi:10.2967/jnumed.121.263202
Journal of nuclear medicine 63(Suppl 1), 68S-74S (2022). doi:10.2967/jnumed.121.263202
The improvement of existing techniques and the development of new molecular imaging methods are an exciting and rapidly developing field in clinical care and research of neurodegenerative disorders. In the clinic, molecular imaging has the potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1264026dbd9e76c39c8e9cab7166267d
https://pubmed.ncbi.nlm.nih.gov/35649650
https://pubmed.ncbi.nlm.nih.gov/35649650
Publikováno v:
Science translational medicine 14(659), eabn5104 (2022). doi:10.1126/scitranslmed.abn5104
Microglial FDG uptake alterations are the source of FDG-PET changes in models of neurodegenerative diseases.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf9e981fe392037a6cd0cdb545d5d870
https://pub.dzne.de/record/165136
https://pub.dzne.de/record/165136
Autor:
Günter U. Höglinger, Matthias Brendel, Nils Briel, Sibylle Ziegler, Michael Willem, Charlotte Spitz, Johannes Levin, Maximilian Deussing, Franz-Josef Gildehaus, Thomas Wiedemann, Gloria Biechele, Karin Wind, Jochen Herms, Sabina Tahirovic, Sara Ribicic, Yuan Shi, Tanja Blume, Robert Perneczky, Peter Bartenstein, Carla Palleis, Sven Lammich, Boris-Stephan Rauchmann, Simon Lindner, Artem Zatcepin, Axel Rominger, Karlheinz Baumann, Katharina Buerger, Florian Eckenweber, Alexander Drzezga, Leonie Beyer, Xianyuan Xiang, Gesine Respondek, Nicolai Franzmeier, Christian Haass
Publikováno v:
Science translational medicine 13(615), eabe5640 (2021). doi:10.1126/scitranslmed.abe5640
2-Deoxy-2-[18F]fluoro-d-glucose positron emission tomography (FDG-PET) is widely used to study cerebral glucose metabolism. Here, we investigated whether the FDG-PET signal is directly influenced by microglial glucose uptake in mouse models and patie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a2ed464903b494989f1b31774cb6b23
https://doi.org/10.1126/scitranslmed.abe5640
https://doi.org/10.1126/scitranslmed.abe5640
Autor:
James B. Rowe, Merle C Hoenig, Ece Kocagoncu, Michael Ewers, Minc faculty, Nicolai Franzmeier, Julia Neitzel, Michel J. Grothe, Alexander Drzezga, Antonio P. Strafella, Thilo van Eimeren, Gérard N. Bischof
Publikováno v:
Eur J Nucl Med Mol Imaging
European journal of nuclear medicine and molecular imaging 46(13), 2819-2830 (2019). doi:10.1007/s00259-019-04394-5
European journal of nuclear medicine and molecular imaging 46(13), 2819-2830 (2019). doi:10.1007/s00259-019-04394-5
Our understanding on human neurodegenerative disease was previously limited to clinical data and inferences about the underlying pathology based on histopathological examination. Animal models and in vitro experiments have provided evidence for a cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d8ff1452a5f301b673b5d12c9aefce2
https://doi.org/10.1007/s00259-019-04394-5
https://doi.org/10.1007/s00259-019-04394-5
Autor:
Thilo van Eimeren, Frank Jessen, Bernd Neumaier, Özgür A. Onur, Jochen Hammes, Klaus Fliessbach, Alexander Drzezga, Gérard N. Bischof, Anja Schneider, Karl Peter Bohn, Merle C. Hönig
Publikováno v:
Journal of nuclear medicine 62(2), 240-246 (2021). doi:10.2967/jnumed.120.244061
Tau protein aggregations are a hallmark of amyloid-associated Alzheimer disease and some forms of non–amyloid-associated frontotemporal lobar degeneration. In recent years, several tracers for in vivo tau imaging have been under evaluation. This st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d9f39cac14700a27d4bb79680608273
Autor:
Alexander Drzezga
Publikováno v:
Journal of nuclear medicine 59(11), 1645-1648 (2018). doi:10.2967/jnumed.117.206300
The network degeneration hypothesis suggests that neurodegenerative disorders are characterized by the spread of molecular neuropathologic features along specific neuronal brain networks, leading to functional impairment of these networks. Interestin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6efcbc53bd864a5ae51c33ebbc3ecac7
https://doi.org/10.2967/jnumed.117.206300
https://doi.org/10.2967/jnumed.117.206300
Autor:
Birgit Ertl-Wagner, Franziska Dorn, Steffen Tiedt, Martin Dichgans, Marco Duering, Christian Barro, Benno Gesierich, Felix J. Bode, Asli Gizem Kaya, Gabor C. Petzold, Jens Kuhle, Lars Kellert, Matthias Klein, Julia Boeck, Frank A. Wollenweber, Nils Peters, Michael W. Goertler
Publikováno v:
Neurology 91(14), e1338-e1347 (2018). doi:10.1212/WNL.0000000000006282
ObjectiveTo explore the utility of serum neurofilament light chain (NfL) as a biomarker for primary and secondary neuroaxonal injury after ischemic stroke (IS) and study its value for the prediction of clinical outcome.MethodsWe used an ultrasensitiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9fbe5138aef4bd3216fe3eaf39e712c
https://doi.org/10.1212/wnl.0000000000006282
https://doi.org/10.1212/wnl.0000000000006282
Autor:
Christian Lambert, Arturo Cardenas-Blanco, Oliver Speck, Matthew J. Betts, Raymond J. Dolan, Luigi Zecca, Kamil Uludag, Martin J. Dahl, James B. Rowe, Anne Maaß, Klaus Fliessbach, Julio Acosta-Cabronero, Nikos Priovoulos, Hartwig R. Siebner, Paula Trujillo, Kathy Y. Liu, Evgeniya Kirilina, Helmut Heinsen, Dimo Ivanov, David Meder, Markus Morawski, Kerrin Pine, Luca Passamonti, Maria Concepcion Garcia Otaduy, Mara Mather, Heidi I.L. Jacobs, Falk Lüsebrink, Dorothea Hämmerer, Ben Inglis, Emrah Düzel, Alexander J. Ehrenberg, Max C. Keuken, Lea T. Grinberg, Hendrik Mattern, Nikolaus Weiskopf, Benedikt A. Poser, Fabio A. Zucca, Robert Howard, Clare Loane, Duygu Tosun, Christopher Fugl Madelung, Martina F. Callaghan
Publikováno v:
Brain 142(9), 2558-2571 (2019). doi:10.1093/brain/awz193
Brain, 142(9), 2558-2571. Oxford University Press
Brain : a journal of neurology, vol 142, iss 9
Brain
Betts, M J, Kirilina, E, Otaduy, M C G, Ivanov, D, Acosta-Cabronero, J, Callaghan, M F, Lambert, C, Cardenas-Blanco, A, Pine, K, Passamonti, L, Loane, C, Keuken, M C, Trujillo, P, Lüsebrink, F, Mattern, H, Liu, K Y, Priovoulos, N, Fliessbach, K, Dahl, M J, Maaß, A, Madelung, C F, Meder, D, Ehrenberg, A J, Speck, O, Weiskopf, N, Dolan, R, Inglis, B, Tosun, D, Morawski, M, Zucca, F A, Siebner, H R, Mather, M, Uludag, K, Heinsen, H, Poser, B A, Howard, R, Zecca, L, Rowe, J B, Grinberg, L T, Jacobs, H I L, Düzel, E & Hämmerer, D 2019, ' Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases ', Brain, vol. 142, no. 9, pp. 2558-2571 . https://doi.org/10.1093/brain/awz193
Brain (Online) 142 (2019): 2558–2571.. doi:10.1093/brain/awz193
info:cnr-pdr/source/autori:Betts M.J.; Kirilina E.; Otaduy M.C.G.; Ivanov D.; Acosta-Cabronero J.; Callaghan M.F.; Lambert C.; Cardenas-Blanco A.; Pine K.; Passamonti L.; Loane C.; Keuken M.C.; Trujillo P.; Lüsebrink F.; Mattern H.; Liu K.Y.; Priovoulos N.; Fliessbach K.; Dahl M.J.; Maaß A.; Madelung C.F.; Meder D.; Ehrenberg A.J.; Speck O.; Weiskopf N.; Dolan R.; Inglis B.; Tosun D.; Morawski M.; Zucca F.A.; Siebner H.R.; Mather M.; Uludag K.; Heinsen H.; Poser B.A.; Howard R.; Zecca L.; Rowe J.B.; Grinberg L.T.; Jacobs H.I.L.; Düzel E.; Hämmerer D./titolo:Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases./doi:10.1093%2Fbrain%2Fawz193/rivista:Brain (Online)/anno:2019/pagina_da:2558/pagina_a:2571./intervallo_pagine:2558–2571./volume:142
Brain, 142(9). Oxford University Press
Brain, 142(9), 2558-2571. Oxford University Press
Brain : a journal of neurology, vol 142, iss 9
Brain
Betts, M J, Kirilina, E, Otaduy, M C G, Ivanov, D, Acosta-Cabronero, J, Callaghan, M F, Lambert, C, Cardenas-Blanco, A, Pine, K, Passamonti, L, Loane, C, Keuken, M C, Trujillo, P, Lüsebrink, F, Mattern, H, Liu, K Y, Priovoulos, N, Fliessbach, K, Dahl, M J, Maaß, A, Madelung, C F, Meder, D, Ehrenberg, A J, Speck, O, Weiskopf, N, Dolan, R, Inglis, B, Tosun, D, Morawski, M, Zucca, F A, Siebner, H R, Mather, M, Uludag, K, Heinsen, H, Poser, B A, Howard, R, Zecca, L, Rowe, J B, Grinberg, L T, Jacobs, H I L, Düzel, E & Hämmerer, D 2019, ' Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases ', Brain, vol. 142, no. 9, pp. 2558-2571 . https://doi.org/10.1093/brain/awz193
Brain (Online) 142 (2019): 2558–2571.. doi:10.1093/brain/awz193
info:cnr-pdr/source/autori:Betts M.J.; Kirilina E.; Otaduy M.C.G.; Ivanov D.; Acosta-Cabronero J.; Callaghan M.F.; Lambert C.; Cardenas-Blanco A.; Pine K.; Passamonti L.; Loane C.; Keuken M.C.; Trujillo P.; Lüsebrink F.; Mattern H.; Liu K.Y.; Priovoulos N.; Fliessbach K.; Dahl M.J.; Maaß A.; Madelung C.F.; Meder D.; Ehrenberg A.J.; Speck O.; Weiskopf N.; Dolan R.; Inglis B.; Tosun D.; Morawski M.; Zucca F.A.; Siebner H.R.; Mather M.; Uludag K.; Heinsen H.; Poser B.A.; Howard R.; Zecca L.; Rowe J.B.; Grinberg L.T.; Jacobs H.I.L.; Düzel E.; Hämmerer D./titolo:Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases./doi:10.1093%2Fbrain%2Fawz193/rivista:Brain (Online)/anno:2019/pagina_da:2558/pagina_a:2571./intervallo_pagine:2558–2571./volume:142
Brain, 142(9). Oxford University Press
The locus coeruleus is the site of the earliest pathological changes in many neurodegenerative diseases. Betts et al. describe how in vivo locus coeruleus imaging can be used as a biomarker for noradrenergic dysfunction in neurodegenerative diseases,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4bace2e8f0b5ec397bb3fa847c6913b