Disruption of orbitofrontal-hypothalamic projections in a murine ALS model and in human patients

Autor: Tobias M. Böckers, Albert C. Ludolph, Jan Kassubek, David Bayer, Luc Dupuis, Hans-Peter Müller, Stefano Antonucci, Volker Rasche, Rami Saad, Francesco Roselli

Publikováno v: Translational Neurodegeneration, Vol 10, Iss 1, Pp 1-17 (2021)
Translational Neurodegeneration
Translational Neurodegeneration, [London] : BioMed Central, 2012-, 2021, 10 (1), pp.17. ⟨10.1186/s40035-021-00241-6⟩
Translational Neurodegeneration, 2021, 10 (1), pp.17. ⟨10.1186/s40035-021-00241-6⟩
Translational neurodegeneration 10(1), 17 (2021). doi:10.1186/s40035-021-00241-6

Background Increased catabolism has recently been recognized as a clinical manifestation of amyotrophic lateral sclerosis (ALS). The hypothalamic systems have been shown to be involved in the metabolic dysfunction in ALS, but the exact extent of hypo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::975db4967a8ff48ee26982bd77308f6e
https://doaj.org/article/a6593394dc8947b5b66f4a710304a553

Left Prefrontal Connectivity Links Subthalamic Stimulation with Depressive Symptoms

Autor: Gregor Wenzel, Jan Niklas Petry-Schmelzer, Alistair Perry, Dorothee Kübler, Friederike Irmen, Gerd-Helge Schneider, Michael T. Barbe, Philip E. Mosley, Ningfei Li, Veerle Visser-Vandewalle, Andrea A. Kühn, Andreas Horn, Haidar S. Dafsari

Publikováno v: Annals of neurology 87(6), 962-975 (2020). doi:10.1002/ana.25734
Annals of Neurology

Objective: Subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD) not only stimulates focal target structures but also affects distributed brain networks. The impact this network modulation has on non-motor DBS effects is no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::774e41262c7f7a6879c57d36786ef1b6

Sex differences in functional and molecular neuroimaging biomarkers of Alzheimer's disease in cognitively normal older adults with subjective memory complaints

Autor: Cavedo, Enrica, Chiesa, Patrizia A., Houot, Marion, Ferretti, Maria Teresa, Grothe, Michel J., Teipel, Stefan J., Lista, Simone, Habert, Marie-Odile, Potier, Marie-Claude, Dubois, Bruno, Hampel, Harald, Bakardjian, Hovagim, Benali, Habib, Bertin, Hugo, Bonheur, Joel, Boukadida, Laurie, Boukerrou, Nadia, Chiesa, Patrizia, Colliot, Olivier, Dubois, Marion, Epelbaum, Stéphane, Gagliardi, Geoffroy, Genthon, Remy, Kas, Aurélie, Lamari, Foudil, Levy, Marcel, Metzinger, Christiane, Mochel, Fanny, Nyasse, Francis, Poisson, Catherine, Revillon, Marie, Santos, Antonio, Andrade, Katia Santos, Sole, Marine, Surtee, Mohmed, de Schotten, Michel Thiebaud, Vergallo, Andrea, Younsi, Nadjia, Aguilar, Lisi Flores, Babiloni, Claudio, Baldacci, Filippo, Benda, Norbert, Black, Keith L., Bokde, Arun L. W., Bonuccelli, Ubaldo, Broich, Karl, Bun, René S., Cacciola, Francesco, Castrillo, Juan, Ceravolo, Roberto, Coman, Cristina-Maria, Corvol, Jean-Christophe, Cuello, Augusto Claudio, Cummings, Jeffrey L., Depypere, Herman, Duggento, Andrea, Durrleman, Stanley, Escott-Price, Valentina, Federoff, Howard, Fiandaca, Massimo, Frank, Richard A., Garaci, Francesco, George, Nathalie, Giorgi, Filippo S., Graziani, Manuela, Haberkamp, Marion, Herholz, Karl, Karran, Eric, Kim, Seung H., Koronyo, Yosef, Koronyo-Hamaoui, Maya, Langevin, Todd, Lehéricy, Stéphane, Lorenceau, Jean, Mapstone, Mark, Neri, Christian, Nisticò, Robert, Nyasse-Messene, Francis, O'Bryant, Sid E., Perry, George, Ritchie, Craig, Rojkova, Katrine, Rossi, Simone, Saidi, Amira, Santarnecchi, Emiliano, Schneider, Lon S., Sporns, Olaf, Toschi, Nicola, Verdooner, Steven R., Villain, Nicolas, Welikovitch, Lindsay A., Woodcock, Janet, Younesi, Erfan

Publikováno v: Alzheimer's and dementia 14(9), 1204-1215 (2018). doi:10.1016/j.jalz.2018.05.014

Observational multimodal neuroimaging studies indicate sex differences in Alzheimer's disease pathophysiological markers.Positron emission tomography brain amyloid load, neurodegeneration (hippocampus and basal forebrain volumes adjusted to total int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b37777bed288ac4e99e1c4a104124ca
https://doi.org/10.1016/j.jalz.2018.05.014

Body Topography Parcellates Human Sensory and Motor Cortex

Autor: Pierre-Louis Bazin, Andreas Schäfer, Daniel S. Margulies, Juliane Dinse, Martin I. Sereno, Estrid Jakobsen, Xiangyu Long, Esther Kuehn, Arno Villringer

Publikováno v: Cerebral cortex 27(7), 3790-3805 (2017). doi:10.1093/cercor/bhx026
Cerebral Cortex (New York, NY)
Cerebral Cortex

The cytoarchitectonic map as proposed by Brodmann currently dominates models of human sensorimotor cortical structure, function, and plasticity. According to this model, primary motor cortex, area 4, and primary somatosensory cortex, area 3b, are hom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea765282fbd1aa236f347c411c939050
https://doi.org/10.1093/cercor/bhx026

Tau deposition is associated with functional isolation of the hippocampus in aging

Autor: Richard Du, Theresa M. Harrison, William J. Jagust, Jenna N. Adams, Anne Maass, Suzanne L. Baker

Publikováno v: Nature communications, vol 10, iss 1
Nature Communications 10(1), 4900 (2019). doi:10.1038/s41467-019-12921-z
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications

The tau protein aggregates in aging and Alzheimer disease and may lead to memory loss through disruption of medial temporal lobe (MTL)-dependent memory systems. Here, we investigated tau-mediated mechanisms of hippocampal dysfunction that underlie th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5883d88128dbc4ded7a9899152d29201
https://escholarship.org/uc/item/3sb5s3zv