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pro vyhledávání: '"diabetes, peptides"'
Autor:
Younis, Mahmoud
Introduction: While diabetes continues to grow as a worldwide major health problem, its cause is obviously simple: β-cell failure. In type 1 diabetes (T1D), β cells are destroyed by autoimmunity, while in type 2 diabetes (T2D), there is a failure o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a42d008e1a9b48a9e9fd06527f9c812f
Publikováno v:
Chemistry (Weinh., Print) 22 (2016): 13287–13300. doi:10.1002/chem.201602816
info:cnr-pdr/source/autori:Magri, Antonio; La Mendola, Diego; Nicoletti, Vincenzo Giuseppe; Pappalardo, Giuseppe; Rizzarelli, Enrico/titolo:New Insight in Copper-Ion Binding to Human Islet Amyloid: The Contribution of Metal-Complex Speciation To Reveal the Polypeptide Toxicity/doi:10.1002%2Fchem.201602816/rivista:Chemistry (Weinh., Print)/anno:2016/pagina_da:13287/pagina_a:13300/intervallo_pagine:13287–13300/volume:22
info:cnr-pdr/source/autori:Magri, Antonio; La Mendola, Diego; Nicoletti, Vincenzo Giuseppe; Pappalardo, Giuseppe; Rizzarelli, Enrico/titolo:New Insight in Copper-Ion Binding to Human Islet Amyloid: The Contribution of Metal-Complex Speciation To Reveal the Polypeptide Toxicity/doi:10.1002%2Fchem.201602816/rivista:Chemistry (Weinh., Print)/anno:2016/pagina_da:13287/pagina_a:13300/intervallo_pagine:13287–13300/volume:22
Type-2 diabetes (T2D) is considered to be a potential threat on a global level. Recently, T2D has been listed as a misfolding disease, such as Alzheimer's and Parkinson's diseases. Human islet amyloid polypeptide (hIAPP) is a molecule cosecreted in p