Zobrazeno 1 - 10
of 2 389
pro vyhledávání: '"dhfr"'
Autor:
Hina Aftab, Saeed Ullah, Ajmal Khan, Mariya al-Rashida, Talha Islam, Kholood A. Dahlous, Saikh Mohammad, Hamdy Kashtoh, Ahmed Al-Harrasi, Zahid Shafiq
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Dihydrofolate reductase (DHFR), an essential enzyme in folate metabolism, presents a promising target for drug development against various diseases, including cancer and tuberculosis. Herein, we present an integrated approach combining in vi
Externí odkaz:
https://doaj.org/article/732fcc615b6948938ec595ad0bf6dde8
Autor:
Laura Rico-San Román, Kai Pascal Alexander Hänggeli, Andrew Hemphill, Pilar Horcajo, Esther Collantes-Fernández, Luis Miguel Ortega-Mora, Ghalia Boubaker
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
As for many other organisms, CRISPR-Cas9 mediated genetic modification has gained increasing importance for the identification of vaccine candidates and drug targets in Neospora caninum, an apicomplexan parasite causing abortion in cattle and neuromu
Externí odkaz:
https://doaj.org/article/380dfd4dffdd44d7813e1951e668dffc
Autor:
Eman M. Sayed, Etify A. Bakhite, Reda Hassanien, Nasser Farhan, Hanan F. Aly, Salma G. Morsy, Nivin A. Hassan
Publikováno v:
BMC Chemistry, Vol 18, Iss 1, Pp 1-19 (2024)
Abstract In this study, we synthesized new 5,6,7,8-tetrahydroisoquinolines and 6,7,8,9-tetrahydrothieno[2,3-c]isoquinolines based on 4-(N,N-dimethylamino)phenyl moiety as expected anticancer and/or antioxidant agents. The structure of all synthesized
Externí odkaz:
https://doaj.org/article/d2e4abd5a00840a0aa8071fdc5b84175
Autor:
Ibrahim M. Salem, Samia M. Mostafa, Ismail Salama, Osama I. El-Sabbagh, Wael A. H. Hegazy, Tarek S. Ibrahim
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1, Pp 203-215 (2023)
The present study aimed to investigate the antitumor effect of simultaneous inhibition of dihydrofolate reductase (DHFR) enzyme. We designed some novel pyrazolo[3,4-d]pyrimidines bearing different amino acid conjugates as efficient antifolate agents
Externí odkaz:
https://doaj.org/article/1b9871a7e6654342ab9bfdb2571fcd71
Autor:
Sawadogo H, Soulama I, Zida A, Zongo C, Sawadogo PM, Guiguemde KT, Nikiema S, Badoum SE, Sawadogo S, Tou A, Sombié S, Tchekounou C, Sermé SS, Ouedraogo-Traoré R, Guiguemdé TR, Savadogo A
Publikováno v:
Infection and Drug Resistance, Vol Volume 16, Pp 6673-6680 (2023)
Haffsatou Sawadogo,1,2 Issiaka Soulama,3,4 Adama Zida,2,5 Cheikna Zongo,1 Patindoilba Marcel Sawadogo,2,5 Kiswendsida Thierry Guiguemde,5,6 Seni Nikiema,7 Salimata Emilie Badoum,1,8 Salam Sawadogo,7 Aïcha Tou,4 Salif Sombié,4 Chanolle Tchekounou,1,
Externí odkaz:
https://doaj.org/article/4c40f0cd40ed4ecf84b987f4caa33569
Publikováno v:
Current Research in Structural Biology, Vol 7, Iss , Pp 100127- (2024)
Acinetobacter baumannii is one of the emerging causes of hospital acquired infections and this bacterium, due to multi-drug resistant and Extensive Drug resistant has been able to develop resistance against the antimicrobial agents that are being use
Externí odkaz:
https://doaj.org/article/6c66bc984477400fb1be283f828a8a21
Autor:
Mater Mahnashi, Mohammed Merae Alshahrani, Amer Al Ali, Abdulaziz Asiri, Mahrous A. Abou-Salim
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
A novel series of multifunctional pyrazolo[3,4-d]pyrimidine-based glutamate analogs (6a–l and 7a,b) have been designed and synthesized as antifolate anticancer agents. Among the tested compounds, 6i exhibited the most potent anti-proliferative acti
Externí odkaz:
https://doaj.org/article/37b6cde31fe648ccb84d13abb5096226
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 3, Pp 1318-1325 (2023)
Dihydrofolate reductase (DHFR), a housekeeping enzyme in primary metabolism, has been extensively studied as a model of acid-base catalysis and a clinic drug target. Herein, we investigated the enzymology of a DHFR-like protein SacH in safracin (SAC)
Externí odkaz:
https://doaj.org/article/df3f533af1fc4b45bed4c51655fc1f64
Autor:
Renu Sehrawat, Ritu Pasrija, Priyanka Rathee, Deepika Kumari, Anurag Khatkar, Esra Küpeli Akkol, Eduardo Sobarzo-Sánchez
Publikováno v:
Antibiotics, Vol 13, Iss 6, p 479 (2024)
A novel series of 1,2,4-triazole analogues of caffeic acid was designed, synthesized, characterized, and assessed for their capacity to inhibit DHFR, as well as their anticancer and antimicrobial properties. A molecular docking analysis was conducted
Externí odkaz:
https://doaj.org/article/49dfd2d6603f43e4b50456d06f17ad3d
Publikováno v:
Biomedicines, Vol 12, Iss 5, p 1079 (2024)
Human dihydrofolate reductase (hDHFR) is an essential cellular enzyme, and inhibiting its activity is a promising strategy for cancer therapy. We have chosen the trimethoprim molecule (TMP) as a model compound in our search for a new class of hDHFR i
Externí odkaz:
https://doaj.org/article/3acb67ff12de46b596d8de0672097109