Zobrazeno 1 - 10
of 432
pro vyhledávání: '"developmental signaling"'
Autor:
Sara Duhachek‐Muggy, Kruttika Bhat, Paul Medina, Fei Cheng, Ling He, Claudia Alli, Mohammad Saki, Sree Deepthi Muthukrishnan, Gregoire Ruffenach, Mansoureh Eghbali, Erina Vlashi, Frank Pajonk
Publikováno v:
Stem Cells Translational Medicine, Vol 9, Iss 1, Pp 106-119 (2020)
Abstract The objective of the study was to identify the mechanism of action for a radiation mitigator of the gastrointestinal (GI) acute radiation syndrome (ARS), identified in an unbiased high‐throughput screen. We used mice irradiated with a leth
Externí odkaz:
https://doaj.org/article/91a88a70c1ea425785506c378e541c3e
Autor:
Patricia A. Umberger, Stacey K. Ogden
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The speckle-type POZ protein (SPOP) functions as a guardian of genome integrity and controls transcriptional regulation by functioning as a substrate adaptor for CUL3/RING-type E3 ubiquitin ligase complexes. SPOP-containing CUL3 complexes target a my
Externí odkaz:
https://doaj.org/article/378722c20b1f4337aa08544dadfd525e
Akademický článek
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Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 6 (2019)
CDK8 and its paralog, CDK19, collectively termed ‘Mediator Kinase,’ are cyclin-dependent kinases that have been implicated as key rheostats in cellular homeostasis and developmental programming. CDK8 and CDK19 are incorporated, in a mutually excl
Externí odkaz:
https://doaj.org/article/5cb522a851e44ac9acad06e538975b46
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Paweł Niewiadomski, Sylwia M. Niedziółka, Łukasz Markiewicz, Tomasz Uśpieński, Brygida Baran, Katarzyna Chojnowska
Publikováno v:
Cells, Vol 8, Iss 2, p 147 (2019)
Gli proteins are transcriptional effectors of the Hedgehog signaling pathway. They play key roles in the development of many organs and tissues, and are deregulated in birth defects and cancer. We review the molecular mechanisms of Gli protein regula
Externí odkaz:
https://doaj.org/article/795fdaf4b8f940fe9c800b6aadf842c0
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2009 Mar 01. 106(9), 3196-3201.
Externí odkaz:
https://www.jstor.org/stable/40443292
Autor:
Deepika Sharma, Anthony J. Mirando, Abigail Leinroth, Jason T. Long, Courtney M. Karner, Matthew J. Hilton
Publikováno v:
PLoS Genetics, Vol 17, Iss 12, p e1009982 (2021)
PLoS Genetics
PLoS Genetics
Sonic Hedgehog/GLI3 signaling is critical in regulating digit number, such that Gli3-deficiency results in polydactyly and Shh-deficiency leads to digit number reductions. SHH/GLI3 signaling regulates cell cycle factors controlling mesenchymal cell p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2ea86c07e1bf91f9d3d03785f979efd
https://doaj.org/article/c0ddf0fe38a04ddc84c2ce80fbc65e0e
https://doaj.org/article/c0ddf0fe38a04ddc84c2ce80fbc65e0e
Autor:
Sara Duhachek-Muggy, Gregoire Ruffenach, Fei Cheng, Paul Medina, Sree Deepthi Muthukrishnan, Claudia Alli, Kruttika Bhat, Frank Pajonk, Mohammad Saki, Erina Vlashi, Mansoureh Eghbali, Ling He
Publikováno v:
Stem Cells Translational Medicine, Vol 9, Iss 1, Pp 106-119 (2020)
Stem cells translational medicine, vol 9, iss 1
Stem Cells Translational Medicine
Stem cells translational medicine, vol 9, iss 1
Stem Cells Translational Medicine
The objective of the study was to identify the mechanism of action for a radiation mitigator of the gastrointestinal (GI) acute radiation syndrome (ARS), identified in an unbiased high‐throughput screen. We used mice irradiated with a lethal dose o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb2d67b5dd592cda68d03406d23b1b9f
https://doi.org/10.1002/sctm.19-0136
https://doi.org/10.1002/sctm.19-0136
Publikováno v:
PLoS ONE
PLoS ONE, Vol 7, Iss 5, p e36941 (2012)
PLoS ONE, Vol 7, Iss 5, p e36941 (2012)
Our previous study shows that inhibiting activator protein one (AP1) transcription factor function in murine epidermis, using dominant-negative c-jun (TAM67), increases cell proliferation and delays differentiation. To understand the mechanism of act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2ad3e5077a9d898978fe9edfcd099c0
http://europepmc.org/articles/PMC7877661
http://europepmc.org/articles/PMC7877661