Zobrazeno 1 - 10
of 3 742
pro vyhledávání: '"deubiquitination"'
Autor:
Yanyan Zhang, Yun Huang, Dianping Yu, Mengting Xu, Hongmei Hu, Qing Zhang, Minchen Cai, Xiangxin Geng, Hongwei Zhang, Jianhua Xia, Mengmeng Guo, Dong Lu, Hanchi Xu, Linyang Li, Xing Zhang, Qun Wang, Sanhong Liu, Weidong Zhang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 10, Pp 4312-4328 (2024)
Programmed cell death ligand-1 (PD-L1) is a T cell inhibitory immune checkpoint molecule that interacts with programmed cell death-1 (PD-1) to promote immune escape of tumor cells. Compared with antibody therapies, small molecule drugs show better pr
Externí odkaz:
https://doaj.org/article/a7130bd47bb441cfbc68faa19f780568
Autor:
Jia‐He Yang, Jun Gao, Ya‐Qi E, Li‐Jie Jiao, Ren Wu, Qiu‐Yi Yan, Zi‐Yi Wei, Guo‐Liang Yan, Jin‐Long Liang, Hong‐Zhu Li
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 15, Iss 5, Pp 2118-2133 (2024)
Abstract Background Hydrogen sulfide (H2S), the third gasotransmitter discovered, regulates a variety of physiological functions. Whether H2S alleviates skeletal muscle ageing by regulating autophagy has not been reported. Methods Mice were administe
Externí odkaz:
https://doaj.org/article/e9e2fa6e578a47f2bf95d2e201fe9c9f
Autor:
Yang Chen, Hengyang Shen, Zhenling Wang, Changzhi Huang, Hongqiang Zhang, Yu Shao, Ying Tong, Lei Xu, Yunfei Lu, Zan Fu
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-17 (2024)
Abstract Background Long-term accumulation of misfolded proteins leads to endoplasmic reticulum (ER) stress in colorectal cancer (CRC). However, the precise pathways controlling the decision between survival and apoptosis in CRC are unclear. Therefor
Externí odkaz:
https://doaj.org/article/654c8e7a60d0478cbf43e94e7c6e84d1
Publikováno v:
BMC Gastroenterology, Vol 24, Iss 1, Pp 1-10 (2024)
Abstract Background MutT homolog 1 (MTH1) sanitizes oxidized dNTP pools to promote the survival of cancer cells and its expression is frequently upregulated in cancers. Polyubiquitination stabilizes MTH1 to facilitate the proliferation of melanoma ce
Externí odkaz:
https://doaj.org/article/54360eb852da4d0da6144b2c07cb19fe
Publikováno v:
Biological Procedures Online, Vol 26, Iss 1, Pp 1-18 (2024)
Abstract Breast cancer is the most common female malignancy worldwide. Ubiquitin-specific peptidase 53 (USP53) has been shown to exert cancer-suppressing functions in several solid tumors, but its role and the underlying mechanism in breast cancer ha
Externí odkaz:
https://doaj.org/article/abe30febad3341fdb4041ba389c1eb68
Publikováno v:
Biology Direct, Vol 19, Iss 1, Pp 1-11 (2024)
Abstract Background Hepatocellular carcinoma (HCC) ranks as the second leading cause of global cancer-related deaths and is characterized by a poor prognosis. Eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) have been proved to play import
Externí odkaz:
https://doaj.org/article/6be795aa0027494ba667787e9f502eea
Autor:
Shunshun Han, Chunlin Yu, Mohan Qiu, Xia Xiong, Han Peng, Xiaoyan Song, Chenming Hu, Zengrong Zhang, Bo Xia, Li Yang, Jialei Chen, Shiliang Zhu, Wen Li, Chaowu Yang
Publikováno v:
Poultry Science, Vol 103, Iss 11, Pp 104209- (2024)
ABSTRACT: The development and maturation of follicles are intricately linked to egg production and reproductive performance of chickens. Granulosa cells death directly affects the development and maturation of follicles, thereby impacting the reprodu
Externí odkaz:
https://doaj.org/article/7e9b8ec6d0c94cb0a5188c272e031572
Autor:
Huiling Guo, Jianwei Wei, Yuyan Zhang, Li Wang, Junhu Wan, Weiwei Wang, Ling Gao, Jiajing Li, Ting Sun, Liwei Ma
Publikováno v:
Genes and Diseases, Vol 11, Iss 6, Pp 101158- (2024)
Ovarian cancer is a common cancer for females, and the incidence and mortality rates are on the rise. Many treatment strategies have been developed for ovarian cancer, including chemotherapy and immunotherapy, but they are often ineffective and prone
Externí odkaz:
https://doaj.org/article/d0929691ff514d34a2726d21bc39c804
Autor:
Haiying Rui, Huaxiang Yu, Kai Chi, Ziqi Han, Wenyong Zhu, Jian Zhang, Haipeng Guo, Wenyi Zou, Fengxin Wang, Ping Xu, Dan Zou, Xiaoshuai Song, Lulu Liu, Xuting Wu, Wenxiao Wu, Dandan Qin, Yihai Cao, Feng Xu, Li Xue, Yuguo Chen
Publikováno v:
Redox Biology, Vol 76, Iss , Pp 103318- (2024)
The aldehyde dehydrogenase 2 (ALDH2) rs671 polymorphism commonly exists in the East Asian populations and is associated with high risks of cardiovascular disease (CVD). However, the cellular and molecular mechanisms that underlie the ALDH2 rs671 muta
Externí odkaz:
https://doaj.org/article/60df617efe8f482e9e81a4db2f777657