Zobrazeno 1 - 10
of 3 672
pro vyhledávání: '"deubiquitination"'
Autor:
Ruiqiu Zhu, Mingyue Li, Difan Wang, Chengzhi Liu, Liwei Xie, Yinyin Yang, Xuhao Gu, Kui Zhao, Ye Tian, Shang Cai
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-17 (2024)
Abstract Background Radiation-induced intestinal injury (RIII) interrupts the scheduled processes of abdominal and pelvic radiotherapy (RT) and compromises the quality of life of cancer survivors. However, the specific regulators and mechanisms under
Externí odkaz:
https://doaj.org/article/966b0e265d814b8fa2708fda4809fbbd
Publikováno v:
Cellular & Molecular Biology Letters, Vol 29, Iss 1, Pp 1-23 (2024)
Abstract Transactivation of epidermal growth factor receptors (EGFR) provides intricate control over multiple regulatory cellular processes that merge the diversity of G protein-coupled receptors (GPCRs) with the robust signaling capacities of recept
Externí odkaz:
https://doaj.org/article/c809f781c35341f786a27114164239b3
Autor:
Yanyan Zhang, Yun Huang, Dianping Yu, Mengting Xu, Hongmei Hu, Qing Zhang, Minchen Cai, Xiangxin Geng, Hongwei Zhang, Jianhua Xia, Mengmeng Guo, Dong Lu, Hanchi Xu, Linyang Li, Xing Zhang, Qun Wang, Sanhong Liu, Weidong Zhang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 10, Pp 4312-4328 (2024)
Programmed cell death ligand-1 (PD-L1) is a T cell inhibitory immune checkpoint molecule that interacts with programmed cell death-1 (PD-1) to promote immune escape of tumor cells. Compared with antibody therapies, small molecule drugs show better pr
Externí odkaz:
https://doaj.org/article/a7130bd47bb441cfbc68faa19f780568
Autor:
Jia‐He Yang, Jun Gao, Ya‐Qi E, Li‐Jie Jiao, Ren Wu, Qiu‐Yi Yan, Zi‐Yi Wei, Guo‐Liang Yan, Jin‐Long Liang, Hong‐Zhu Li
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 15, Iss 5, Pp 2118-2133 (2024)
Abstract Background Hydrogen sulfide (H2S), the third gasotransmitter discovered, regulates a variety of physiological functions. Whether H2S alleviates skeletal muscle ageing by regulating autophagy has not been reported. Methods Mice were administe
Externí odkaz:
https://doaj.org/article/e9e2fa6e578a47f2bf95d2e201fe9c9f
Autor:
Yang Chen, Hengyang Shen, Zhenling Wang, Changzhi Huang, Hongqiang Zhang, Yu Shao, Ying Tong, Lei Xu, Yunfei Lu, Zan Fu
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-17 (2024)
Abstract Background Long-term accumulation of misfolded proteins leads to endoplasmic reticulum (ER) stress in colorectal cancer (CRC). However, the precise pathways controlling the decision between survival and apoptosis in CRC are unclear. Therefor
Externí odkaz:
https://doaj.org/article/654c8e7a60d0478cbf43e94e7c6e84d1
Publikováno v:
BMC Gastroenterology, Vol 24, Iss 1, Pp 1-10 (2024)
Abstract Background MutT homolog 1 (MTH1) sanitizes oxidized dNTP pools to promote the survival of cancer cells and its expression is frequently upregulated in cancers. Polyubiquitination stabilizes MTH1 to facilitate the proliferation of melanoma ce
Externí odkaz:
https://doaj.org/article/54360eb852da4d0da6144b2c07cb19fe
Publikováno v:
Biological Procedures Online, Vol 26, Iss 1, Pp 1-18 (2024)
Abstract Breast cancer is the most common female malignancy worldwide. Ubiquitin-specific peptidase 53 (USP53) has been shown to exert cancer-suppressing functions in several solid tumors, but its role and the underlying mechanism in breast cancer ha
Externí odkaz:
https://doaj.org/article/abe30febad3341fdb4041ba389c1eb68
Publikováno v:
Biology Direct, Vol 19, Iss 1, Pp 1-11 (2024)
Abstract Background Hepatocellular carcinoma (HCC) ranks as the second leading cause of global cancer-related deaths and is characterized by a poor prognosis. Eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) have been proved to play import
Externí odkaz:
https://doaj.org/article/6be795aa0027494ba667787e9f502eea
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
IntroductionProtein homeostasis is maintained by the opposing action of ubiquitin ligase and deubiquitinase, two important components of the ubiquitin-proteasome pathway, and contributes to both normal physiological and pathophysiological processes.
Externí odkaz:
https://doaj.org/article/bfa423f9d01e45bdbaa76b2427ed7149