Zobrazeno 1 - 10
of 2 184
pro vyhledávání: '"deubiquitinase"'
Autor:
Alireza Zangooie, Shima Tavoosi, Mahan Arabhosseini, Aram Halimi, Helia Zangooie, Amir Hossein Baghsheikhi, Soheila Rahgozar, Mohammad Ahmadvand, Alireza Mosavi Jarrahi, Zahra Salehi
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-16 (2024)
Abstract Background Leukemia, a type of blood cell cancer, is categorized by the type of white blood cells affected (lymphocytes or myeloid cells) and disease progression (acute or chronic). In 2020, it ranked 15th among the most diagnosed cancers an
Externí odkaz:
https://doaj.org/article/a03ca13de0b240f6ac9f62ddb2e82125
Autor:
Qi Zhang, Zihan Chen, Jinglei Li, Kunpeng Huang, Zhihao Ding, Biao Chen, Tianxing Ren, Peng Xu, Guoliang Wang, Hongji Zhang, Xiao-Dong Zhang, Jinxiang Zhang, Hui Wang
Publikováno v:
Redox Biology, Vol 75, Iss , Pp 103287- (2024)
Hepatic ischemia/reperfusion (I/R) injury is an important cause of liver function impairment following liver surgery. The ubiquitin-proteasome system (UPS) plays a crucial role in protein quality control and has substantial impact on the hepatic I/R
Externí odkaz:
https://doaj.org/article/99dfc1b12e23455b9ff48dc7a833f3b1
Autor:
Yunhui Li, Lei Li, Xinshu Wang, Fei Zhao, Yuntong Yang, Yujuan Zhou, Jiyuan Zhang, Li Wang, Zeshan Jiang, Yuanyuan Zhang, Yuping Chen, Chenming Wu, Ke Li, Tingting Zhang, Ping Wang, Zhiyong Mao, Weiguo Zhu, Xingzhi Xu, Shikang Liang, Zhenkun Lou, Jian Yuan
Publikováno v:
Advanced Science, Vol 11, Iss 28, Pp n/a-n/a (2024)
Abstract DNA damage plays a significant role in the tumorigenesis and progression of the disease. Abnormal DNA repair affects the therapy and prognosis of cancer. In this study, it is demonstrated that the deubiquitinase USP25 promotes non‐homologo
Externí odkaz:
https://doaj.org/article/15c5e763094144a7a13720809e1edf7a
Autor:
Jiaqi Huang, Qianqian Yin, Yuqing Wang, Xin Zhou, Yunyun Guo, Yuanjun Tang, Rui Cheng, Xiaotong Yu, Jie Zhang, Chen Huang, Zhanya Huang, Jianlin Zhang, Zhengyang Guo, Xiao Huo, Yan Sun, Yanfang Li, Hao Wang, Jianling Yang, Lixiang Xue
Publikováno v:
Advanced Science, Vol 11, Iss 23, Pp n/a-n/a (2024)
Abstract The regulation of PD‐L1 is the key question, which largely determines the outcome of the immune checkpoint inhibitors (ICIs) based therapy. However, besides the transcription level, the protein stability of PD‐L1 is closely correlated wi
Externí odkaz:
https://doaj.org/article/d6dbdb4db2dc4d5bb8cacfb58f1b695d
Autor:
Cheng Zhou, Xuehu Zhang, Hangbin Ma, Yinghao Zhou, Yibo Meng, Chenchen Chen, Guowei Shi, Wandong Yu, Jun Zhang
Publikováno v:
BMC Urology, Vol 24, Iss 1, Pp 1-11 (2024)
Abstract Background USP54, a ubiquitin-specific protease in the deubiquitinase (DUB) family, facilitates the malignant progression of several types of cancer. However, the role of USP54 in prostate cancer (PCa), especially castration-resistant prosta
Externí odkaz:
https://doaj.org/article/1ef892c83f4e4c48ab2f7cda93033182
Publikováno v:
Veterinary Research, Vol 55, Iss 1, Pp 1-15 (2024)
Abstract Toxoplasma gondii is among the most important parasites worldwide. The apicoplast is a unique organelle shared by all Apicomplexan protozoa. Increasing lines of evidence suggest that the apicoplast possesses its own ubiquitination system. De
Externí odkaz:
https://doaj.org/article/c46cf0912a904a5ea0155c87c7a3997c
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
OTULIN deficiency is a complex disease characterized by a wide range of clinical manifestations, including skin rash, joint welling, lipodystrophy to pulmonary abscess, and sepsis shock. This disease is mechanistically linked to mutations in the OTUL
Externí odkaz:
https://doaj.org/article/74ed912d91db415f960ca1e8a768d696
Autor:
Lu Ding, Yang Sun, Yan Liang, Jie Zhang, Zhendong Fu, Caiyue Ren, Pengfei Li, Wen Liu, Rong Xiao, Hao Wang, Zhaoying Zhang, Xuetian Yue, Chunyang Li, Zhuanchang Wu, Yuemin Feng, Xiaohong Liang, Chunhong Ma, Lifen Gao
Publikováno v:
Advanced Science, Vol 11, Iss 16, Pp n/a-n/a (2024)
Abstract Inadequate β‐cell mass and insulin secretion are essential for the development of type 2 diabetes (T2D). TNF‐α‐induced protein 8‐like 1 (Tipe1) plays a crucial role in multiple diseases, however, a specific role in T2D pathogenesis
Externí odkaz:
https://doaj.org/article/4156cecc84ad4a0e8710791f05e9deea
Autor:
Seema Zadi, Sumaira Javaid, Atia-tul-Wahab, Humaira Zafar, Muhammad Awais, Innokentiy Maslennikov, M. Iqbal Choudhary
Publikováno v:
Heliyon, Vol 10, Iss 5, Pp e26345- (2024)
Ubiquitin-specific protease7 (USP7) regulates the stability of the p53 tumor suppressor protein and several other proteins critical for tumor cell survival. Aberrant expression of USP7 facilitates human malignancies by altering the activity of proto-
Externí odkaz:
https://doaj.org/article/a3f986d778754196a171c92e4a18f2ae
Autor:
Keqiang Zhang, Ting Sun, Wendong Li, Yuming Guo, Aimin Li, Marcus Hsieh, Jinghan Wang, Jun Wu, Leonidas Arvanitis, Dan J. Raz
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-16 (2023)
Abstract Deubiquitinases (DUBs) play important roles in various human cancers and targeting DUBs is considered as a novel anticancer therapeutic strategy. Overexpression of ubiquitin specific protease 7 and 22 (USP7 and USP22) are associated with mal
Externí odkaz:
https://doaj.org/article/9418c66ed2374292bc602b7430429b92