Mathematical modeling of hypoxia and adenosine to explore tumor escape mechanisms in DC-based immunotherapy

Autor: Elahe Ghiyabi, Abazar Arabameri, Mostafa Charmi

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)

Abstract Identifying and controlling tumor escape mechanisms is crucial for improving cancer treatment effectiveness. Experimental studies reveal tumor hypoxia and adenosine as significant contributors to such mechanisms. Hypoxia exacerbates adenosin

Externí odkaz: https://doaj.org/article/b8689aac524641e7a86b2be0129b693c

Case Report: In Situ Vaccination by Autologous CD16+ Dendritic Cells and Anti-PD-L 1 Antibody Synergized With Radiotherapy To Boost T Cells-Mediated Antitumor Efficacy In A Psoriatic Patient With Cutaneous Squamous Cell Carcinoma

Autor: Jun-Wei Huang, Chun-Lin Kuo, Li-Tzu Wang, Kevin Sheng-Kai Ma, Wen-Yen Huang, Feng-Cheng Liu, Kuender D. Yang, Bing-Heng Yang

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

The combination of radiotherapy and immunotherapy improves the survival rate of patients with malignancies developed through escape from T-cell-mediated immune surveillance. Immune checkpoint inhibitors, such as anti-programmed cell death protein-lig

Externí odkaz: https://doaj.org/article/e026164313a1409ab201c20478155eaf

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Nuclear receptor Nur77 deficiency alters dendritic cell function

Autor: Carlie J. de Vries, Hiroshi Ichinose, Marleen Ansems, Nina Tel-Karthaus, Esther D. Kers-Rebel, Maaike W. G. Looman

Publikováno v: Frontiers in immunology, 9(AUG):1797. Frontiers Media S.A.
Frontiers in Immunology, 9
Frontiers in Immunology
Frontiers in Immunology, Vol 9 (2018)

Dendritic cells (DCs) are the professional antigen-presenting cells of the immune system. Proper function of DCs is crucial to elicit an effective immune response against pathogens and to induce antitumor immunity. Different members of the nuclear re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2e97019cb7bb42c2a9939c42790fe18
https://pure.amc.nl/en/publications/nuclear-receptor-nur77-deficiency-alters-dendritic-cell-function(5d5c2cc2-0940-4411-b49d-935f16899776).html