Zobrazeno 1 - 10
of 680
pro vyhledávání: '"den Dunnen Johan T"'
Autor:
Mastrokolias Anastasios, den Dunnen Johan T, van Ommen GertJan B, 't Hoen Peter AC, van Roon-Mom Willeke MC
Publikováno v:
BMC Genomics, Vol 13, Iss 1, p 28 (2012)
Abstract Background Transcriptome analysis is of great interest in clinical research, where significant differences between individuals can be translated into biomarkers of disease. Although next generation sequencing provides robust, comparable and
Externí odkaz:
https://doaj.org/article/73aa8a3a63cd4d22a79779fb888dab24
Autor:
van Ommen Gert Jan B, den Dunnen Johan T, de Gorter David JJ, Terlouw Samuel, van Heiningen Sandra H, Hoogaars Willem MH, Kemaladewi Dwi U, Aartsma-Rus Annemieke, ten Dijke Peter, 't Hoen Peter AC
Publikováno v:
BMC Medical Genomics, Vol 4, Iss 1, p 36 (2011)
Abstract Background Myostatin is a potent muscle growth inhibitor that belongs to the Transforming Growth Factor-β (TGF-β) family. Mutations leading to non functional myostatin have been associated with hypermuscularity in several organisms. By con
Externí odkaz:
https://doaj.org/article/07a8f75a00944b1382c2e811e51b786e
Publikováno v:
BMC Genomics, Vol 11, Iss 1, p 716 (2010)
Abstract Background MicroRNAs are small non-coding RNA transcripts that regulate post-transcriptional gene expression. The millions of short sequence reads generated by next generation sequencing technologies make this technique explicitly suitable f
Externí odkaz:
https://doaj.org/article/75d6665bf5524188afb0da1f8753c6cc
Autor:
den Dunnen Johan T, Chin-A-Woeng Thomas FC, Dibbits Bert W, Veenendaal Albertine, Crooijmans Richard PMA, Kerstens Hindrik HD, Groenen Martien AM
Publikováno v:
BMC Genomics, Vol 10, Iss 1, p 479 (2009)
Abstract Background The development of second generation sequencing methods has enabled large scale DNA variation studies at moderate cost. For the high throughput discovery of single nucleotide polymorphisms (SNPs) in species lacking a sequenced ref
Externí odkaz:
https://doaj.org/article/a232bf8900454b42b1c85788fcd0e99a
Autor:
den Dunnen Johan T, Kloosterman Ate D, van Duijn Kate, Kersbergen Paula, Kayser Manfred, de Knijff Peter
Publikováno v:
BMC Genetics, Vol 10, Iss 1, p 69 (2009)
Abstract Background The identification and use of Ancestry-Sensitive Markers (ASMs), i.e. genetic polymorphisms facilitating the genetic reconstruction of geographical origins of individuals, is far from straightforward. Results Here we describe the
Externí odkaz:
https://doaj.org/article/da3dc73bae434ef284902c1fb5d118c9
Autor:
den Dunnen Johan T, Povey Sue, Ekong Rosemary, Sampson Julian, Kwiatkowski David, Hoogeveen-Westerveld Marianne, Mozaffari Melika, van den Ouweland Ans, Halley Dicky, Nellist Mark
Publikováno v:
BMC Medical Genetics, Vol 10, Iss 1, p 88 (2009)
Abstract Background Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterised by the development of hamartomas in a variety of organs and tissues. The disease is caused by mutations in either the TSC1 gene on chromosome 9q34, o
Externí odkaz:
https://doaj.org/article/db660f5d451042aab2d87fb45d111a89
Autor:
Crooijmans Richard PMA, Dibbits Bert, Heuven Henri CM, Kerstens Hindrik HD, Megens Hendrik-Jan, Amaral Andreia J, den Dunnen Johan T, Groenen Martien AM
Publikováno v:
BMC Genomics, Vol 10, Iss 1, p 374 (2009)
Abstract Background Although the Illumina 1 G Genome Analyzer generates billions of base pairs of sequence data, challenges arise in sequence selection due to the varying sequence quality. Therefore, in the framework of the International Porcine SNP
Externí odkaz:
https://doaj.org/article/14441bf2e72c42eab4b900e3a0332061
Autor:
van Ommen Gert-Jan B, Vossen Rolf HAM, Schut Menno H, Pepers Barry A, den Dunnen Johan T, van Roon-Mom Willeke MC
Publikováno v:
BMC Biotechnology, Vol 9, Iss 1, p 50 (2009)
Abstract Background Methodologies like phage display selection, in vitro mutagenesis and the determination of allelic expression differences include steps where large numbers of clones need to be compared and characterised. In the current study we sh
Externí odkaz:
https://doaj.org/article/e7a7be47267341599548c150a92bdd81
Autor:
den Dunnen Johan T, van Ommen Gert-Jan B, Villerius Michel P, van Galen Michiel, Hestand Matthew S, 't Hoen Peter AC
Publikováno v:
BMC Bioinformatics, Vol 9, Iss 1, p 495 (2008)
Abstract Background The identification of transcription factor binding sites is difficult since they are only a small number of nucleotides in size, resulting in large numbers of false positives and false negatives in current approaches. Computationa
Externí odkaz:
https://doaj.org/article/2761837e2bdd49a0878f324ddf8dd7f9
Autor:
van Ommen Gert-Jan B, den Dunnen Johan T, Sterrenburg Ellen, 't Hoen Peter AC, Jelier Rob, Kors Jan A, Mons Barend
Publikováno v:
BMC Bioinformatics, Vol 9, Iss 1, p 291 (2008)
Abstract Background Comparative analysis of expression microarray studies is difficult due to the large influence of technical factors on experimental outcome. Still, the identified differentially expressed genes may hint at the same biological proce
Externí odkaz:
https://doaj.org/article/2d5c80381d17436aaef295bafd0f093e