Zobrazeno 1 - 10
of 247
pro vyhledávání: '"deming sun"'
Publikováno v:
Current Research in Immunology, Vol 3, Iss , Pp 73-84 (2022)
The extracellular level of adenosine increases greatly during inflammation, which modulates immune responses. We have previously reported that adenosine enhances Th17 responses while it suppresses Th1 responses. This study examined whether response o
Externí odkaz:
https://doaj.org/article/16cf4c93c4734173a5fcd4761b832e64
Publikováno v:
Biomolecules, Vol 13, Iss 10, p 1432 (2023)
Autoimmune diseases caused by T cells can arise from either T-helper 1 (Th1) or T-helper 17 (Th17)-type pathogenic T cells. However, it is unclear whether these two T-cell subsets are influenced by distinct pathogenic factors and whether treatments t
Externí odkaz:
https://doaj.org/article/8fb8d60bd5024b1e9be20f9a31077738
Publikováno v:
Current Research in Immunology, Vol 2, Iss , Pp 93-103 (2021)
Various pathological conditions are accompanied by release of adenosine triphosphate (ATP) from the intracellular to the extracellular compartment, where it degrades into adenosine and modulates immune responses. Previous studies concluded that both
Externí odkaz:
https://doaj.org/article/675aeefd4b8349b58f5698c91088f3a2
Autor:
Judy A. MacArthur Clark, Deming Sun
Publikováno v:
Animal Models and Experimental Medicine, Vol 3, Iss 1, Pp 103-113 (2020)
ABSTRACT These Chinese National Guidelines (GB/T 35892‐20181) were issued February 06, 2018 and became effective September 01, 2018. The authors recognized the urgent need for an authentic English translation to inform the international community o
Externí odkaz:
https://doaj.org/article/aa4c95ee85f5415a9debf99e8c92e768
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Previous studies have shown that CD73 is pivotal in the conversion of pro-inflammatory adenosine triphosphate into anti-inflammatory adenosine and that immune cells of the same type that express different levels of CD73 are functionally distinct. In
Externí odkaz:
https://doaj.org/article/46c437831b38430498dbc53953f0d2a0
Autor:
Zhoutao He, Xiaoning Sun, Zhichao Ma, Jiao Fu, Baili Huang, Fujin Liu, Yi Chen, Taozhi Deng, Xiangyang Han, Deming Sun, Cheng Lan
Publikováno v:
Cell & Bioscience, Vol 8, Iss 1, Pp 1-9 (2018)
Abstracts Background This study investigated the role of HSP70 in modulating intestinal γδ T cells’ Th17 response in Trichinella spiralis-induced PI-IBS mice model. Methods The intestinal HSP70’s expression and mRNA level were measured by Weste
Externí odkaz:
https://doaj.org/article/2991c9e98a2d4d089b84865d6e0ee63e
Autor:
Ronglan Zhao, Jinjuan Qiao, Xumei Zhang, Yansong Zhao, Xiangying Meng, Deming Sun, Xiaoxiang Peng
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Toll-like receptors (TLRs) trigger innate immune responses through their recognition of conserved molecular ligands of either endogenous or microbial origin. Although activation, function, and signaling pathways of TLRs were already well-studied, the
Externí odkaz:
https://doaj.org/article/c5a55047ce1a4ac9b9c6dbcd8ef40222
Autor:
Swati Popat Phalke, Yafei Huang, Kira Rubtsova, Andrew Getahun, Deming Sun, Richard L Reinhardt, Rebecca L O'Brien, Willi K Born
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0218827 (2019)
Size and composition of γδ T cell populations change dramatically with tissue location, during development, and in disease. Given the functional differentiation of γδ T cell subsets, such shifts might alter the impact of γδ T cells on the immun
Externí odkaz:
https://doaj.org/article/6e77a4c1673248d6813c0c1a7c07637b
Autor:
Dongchun Liang, Jeong-Im Woo, Hui Shao, Willi K Born, Rebecca L O'Brien, Henry J Kaplan, Deming Sun
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197189 (2018)
Whether γδ T cells inhibit or enhance the Foxp3 T cell response depends upon their activation status. The critical enhancing effector in the supernatant is adenosine. Activated γδ T cells express adenosine receptors at high levels, which enables
Externí odkaz:
https://doaj.org/article/160b4676efa74df4a6b0b6524420edf6
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0199601 (2018)
We previously reported that activated γδ T cells greatly enhance autoimmune responses, particularly the Th17 response. To determine the mechanisms involved, we made a series of comparisons between activated and non-activated γδ T cells. Our resul
Externí odkaz:
https://doaj.org/article/0f138dd9efc742369bb0d95489fbbda9