Zobrazeno 1 - 10
of 1 887
pro vyhledávání: '"delta-opioid receptor"'
A novel delta opioid receptor specific peptide reduces craving in an animal model of cocaine seeking
Autor:
Pnina Shirel Itzhak-Israeli, Hevroni Yael, Erez Matsree, Hilla Pe'er-Nissan, Shira Ofer Lancman, Barnea R, Luboshits G, Menachem Motiei, Oshra Betzer, Iris Gispan, Rachela Popovtzer, Yaakov Anker, Firer MA, Yadid G
Publikováno v:
Addiction Neuroscience, Vol 12, Iss , Pp 100159- (2024)
Substance use disorder, and particularly cocaine use disorder, is a complex disease that affects societal, economic, and psychological factors. Endogenous β-endorphin released after prolonged cocaine withdrawal has been reported to activate the accu
Externí odkaz:
https://doaj.org/article/d741b3c5cfe5434b9ad64e270aaa1e8c
Autor:
Ayako Kawaminami, Daisuke Yamada, Toshinori Yoshioka, Azumi Hatakeyama, Moeno Nishida, Keita Kajino, Tsuyoshi Saitoh, Hiroshi Nagase, Akiyoshi Saitoh
Publikováno v:
Neuropsychopharmacology Reports, Vol 44, Iss 1, Pp 256-261 (2024)
Abstract Aim Excitatory projections from the prelimbic cortex (PL) to the basolateral nucleus of the amygdala (BLA) are implicated in the regulation of anxiety‐like behaviors, and we previously demonstrated that anxiolytic‐like effects of the sel
Externí odkaz:
https://doaj.org/article/b4c8e0fe11204d0f9b4c52cf4d1b04ad
Autor:
Sophia C. Levis, Matthew T. Birnie, Yiyan Xie, Noriko Kamei, Puja V. Kulkarni, Johanna S. Montesinos, Christina R. Perrone, Catherine M. Cahill, Tallie Z. Baram, Stephen V. Mahler
Publikováno v:
Addiction Neuroscience, Vol 13, Iss , Pp 100175- (2024)
Opioid use disorder (OUD) is associated with a history of early-life adversity (ELA), an association that is particularly strong in women. In a rodent model, we previously found that ELA enhances risk for opioid addiction selectively in females, but
Externí odkaz:
https://doaj.org/article/8d64dd9956d94e94af54816248959924
Autor:
Eliyahu Dremencov, Henrieta Oravcova, Daniil Grinchii, Zuzana Romanova, Roman Dekhtiarenko, Lubica Lacinova, Daniela Jezova
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Background: There is growing evidence that the treatment of several mental disorders can potentially benefit from activation of delta-opioid receptors. In the future, delta-agonists with a safe pharmacological profile can be used for the treatment of
Externí odkaz:
https://doaj.org/article/46edd60e42a2417c90e34163c8920a2f
Publikováno v:
Molecules, Vol 29, Iss 14, p 3331 (2024)
We recently developed a series of nalfurafine analogs (TK10, TK33, and TK35) that may serve as non-addictive candidate analgesics. These compounds are mixed-action agonists at the kappa and delta opioid receptors (KOR and DOR, respectively) and produ
Externí odkaz:
https://doaj.org/article/3bd22c861a0e4555aaa74314112260cd
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: Modern methods for quantifying signaling bias at G protein–coupled receptors (GPCRs) rely on using a single β-arrestin isoform. However, it is increasingly appreciated that the two β-arrestin isoforms have unique roles, requiring the
Externí odkaz:
https://doaj.org/article/226cef4e1ff64cb6bf6f37cbbe6fe9e4
Autor:
Lu Wang, Jing Li, Fengxia Ren, Hongxin Jia, Zixing Yu, Jingchao Cheng, Tao Zhang, Weiguo Shi, Xuesong Feng
Publikováno v:
Arabian Journal of Chemistry, Vol 16, Iss 8, Pp 105018- (2023)
For the treatment of pain, the design of a bifunctional mu-opioid receptor (MOR)/delta-opioid receptor (DOR) agonist is an effective strategy to seek safer opioids with higher antinociceptive efficacy and diminished adverse side effects. Herein, we d
Externí odkaz:
https://doaj.org/article/63137ff92a5342cdb7c6e1a5468c7d35
Autor:
Keith M. Olson, Andrea L. Devereaux, Payal Chatterjee, Savanah L. Saldaña-Shumaker, Amanda Shafer, Adam Plotkin, Ram Kandasamy, Alexander D. MacKerell, John R. Traynor, Christopher W. Cunningham
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: There is a major societal need for analgesics with less tolerance, dependence, and abuse liability. Preclinical rodent studies suggest that bifunctional ligands with both mu (MOPr) and delta (DOPr) opioid peptide receptor activity may p
Externí odkaz:
https://doaj.org/article/d66de2654cdc423f8f571b1ac7860458
Autor:
Yangmei Li, Shainnel O. Eans, Michelle Ganno-Sherwood, Abbe Eliasof, Richard A. Houghten, Jay P. McLaughlin
Publikováno v:
Molecules, Vol 28, Iss 22, p 7548 (2023)
Peptide-based opioid ligands are important candidates for the development of novel, safer, and more effective analgesics to treat pain. To develop peptide-based safer analgesics, we synthesized a mixture-based cyclic pentapeptide library containing a
Externí odkaz:
https://doaj.org/article/a54656c2537040219523f325ecf69be0
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