Výsledky vyhledávání - "delta-agonists"

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N-Phenethyl Substitution in 14-Methoxy-N-methylmorphinan-6-ones Turns Selective mu Opioid Receptor Ligands into Dual mu/delta Opioid Receptor Agonists

Autor: Dumitrascuta, Maria, Bermúdez, Marcel, Ben Haddou, Tanila, Guerrieri, Elena, Schläfer, Lea, Ritsch, Andreas, Hosztafi, Sandor, Lantero, Aquilino, Kreutz, Christoph, Wolber, Gerhard

Morphine and structurally-derived compounds are mu opioid receptor (mu OR) agonists, and the most effective analgesic drugs. However, their usefulness is limited by serious side effects, including dependence and abuse potential. The N-substituent in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1769271c0835d5aa47f022c41fb4fa4

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Dose-dependent effects of peroxisome proliferator-activated receptors β/δ agonist on systemic inflammation after haemorrhagic shock

Autor: Martijn van Griensven, Michel Teuben, Daniel Busch, Hans-Christoph Pape, Roman Pfeifer, Luxu Yin, Zhi Qiao, Frank Hildebrand

Publikováno v: Cytokine, 103, 127-132. Elsevier Science

Introduction PPARβ/δ agonists are known to modulate the systemic inflammatory response after sepsis. In this study, inflammation modulation effects of PPARβ/δ are investigated using the selective PPARβ/δ agonist (GW0742) in a model of haemorrha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c59d0f2f83f844fc185da7af619d145
https://cris.maastrichtuniversity.nl/en/publications/764d8d6b-dc33-420f-a1bd-4462c0f8d2db

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Discovering highly selective and diverse PPAR-delta agonists by ligand based machine learning and structural modeling

Autor: Anwar Rayan, Amiram Goldblum, Jianwei Che, David Marcus, Benny Da’adoosh, Frederick J. King

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports

PPAR-δ agonists are known to enhance fatty acid metabolism, preserving glucose and physical endurance and are suggested as candidates for treating metabolic diseases. None have reached the clinic yet. Our Machine Learning algorithm called “Iterati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d166c3a84706022173d6df4e6e1070b1
https://doi.org/10.1038/s41598-019-38508-8

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Novel molecular therapies for coronary stents

Autor: Hytönen, Jarkko

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3891::d10a8189cf575d1ca6886b14c77c14c0
http://urn.fi/URN:ISBN:978-952-61-2896-2

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Evaluation of Peroxisome Proliferator-activated receptor beta/delta behavior in skin regeneration processes and its modulation by ligands

Autor: Natália Bernardi Videira

Publikováno v: Biblioteca Digital de Teses e Dissertações da Universidade Estadual de Campinas (UNICAMP)
Universidade Estadual de Campinas (UNICAMP)
instacron:UNICAMP

Orientador: Ana Carolina Migliorini Figueira Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia Resumo: Os Receptores Ativadores da Proliferacao de Peroxissomos (PPAR) sao fatores de transcricao modulados por ligantes e perte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95686f670f6925b2f0f94b5e6831164f

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PPARγ Agonists Attenuate Trigeminal Neuropathic Pain

Autor: Liping Zhang, Craig S. Miller, Danielle N. Lyons, Karin N. Westlund, Robert J. Danaher

Publikováno v: The Clinical journal of pain. 33(12)

The aim of this study is to investigate the role of peroxisome proliferator-activated receptor-gamma isoform (PPARγ), in trigeminal neuropathic pain utilizing a novel mouse trigeminal inflammatory compression (TIC) injury model. The study determined

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63ed32b9465b6869790c844cfecb0fa1
https://pubmed.ncbi.nlm.nih.gov/28514232

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