Zobrazeno 1 - 10
of 107
pro vyhledávání: '"deleterious variants"'
Publikováno v:
Heliyon, Vol 10, Iss 11, Pp e31885- (2024)
Background: Dystonia is a kind of movement disorder but its pathophysiological mechanisms are still largely unknown. Recent evidence reveals that genetical defects may play important roles in the pathogenesis of dystonia. Objectives and Methods: -To
Externí odkaz:
https://doaj.org/article/1856ea79002e4b52868a9c15ff079db8
Publikováno v:
Journal of Human, Earth, and Future, Vol 3, Iss 0, Pp 22-29 (2022)
Animals are used as preclinical models for human diseases in drug development. Dogs, especially, are used in preclinical research to support clinical safety evaluations during drug development. Comparisons of patterns of regions of homozygosity (ROH)
Externí odkaz:
https://doaj.org/article/c7dd084eb6c84eb498a47f1f15b90db1
Akademický článek
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Autor:
Langqing Liu, Mirte Bosse, Hendrik‐Jan Megens, Manon de Visser, Martien A. M.Groenen, Ole Madsen
Publikováno v:
Evolutionary Applications, Vol 14, Iss 3, Pp 710-720 (2021)
Abstract Increasing human disturbance and climate change have a major impact on habitat integrity and size, with far‐reaching consequences for wild fauna and flora. Specifically, population decline and habitat fragmentation result in small, isolate
Externí odkaz:
https://doaj.org/article/abfe8123e4f54247bbbf06c6a83116aa
Autor:
Clive T. Darwell, Samart Wanchana, Vinitchan Ruanjaichon, Meechai Siangliw, Burin Thunnom, Wanchana Aesomnuk, Theerayut Toojinda
Publikováno v:
Frontiers in Plant Science, Vol 13 (2022)
Agricultural crop breeding programs, particularly at the national level, typically consist of a core panel of elite breeding cultivars alongside a number of local landrace varieties (or other endemic cultivars) that provide additional sources of phen
Externí odkaz:
https://doaj.org/article/6f0aa93adaaa4f17a06e49ef8b469cf6
Autor:
Hong-xu Pan, Yu-wen Zhao, Jun-pu Mei, Zheng-huan Fang, Yige Wang, Xun Zhou, Yang-jie Zhou, Rui Zhang, Kai-lin Zhang, Li Jiang, Qian Zeng, Yan He, Zheng Wang, Zhen-hua Liu, Qian Xu, Qi-ying Sun, Yang Yang, Ya-cen Hu, Ya-se Chen, Juan Du, Li-fang Lei, Hai-nan Zhang, Chun-yu Wang, Xin-xiang Yan, Lu Shen, Hong Jiang, Jie-qiong Tan, Jin-chen Li, Bei-sha Tang, Ji-feng Guo
Publikováno v:
Translational Neurodegeneration, Vol 9, Iss 1, Pp 1-12 (2020)
Abstract Background Common and rare variants of guanosine triphosphate cyclohydrolase 1 (GCH1) gene may play important roles in Parkinson’s disease (PD). However, there is a lack of comprehensive analysis of GCH1 genotypes, especially in non-coding
Externí odkaz:
https://doaj.org/article/e37c50f7cbe541038d65d3dfff802d0e
Autor:
Chiara Bortoluzzi, Mirte Bosse, Martijn F. L. Derks, Richard P. M. A. Crooijmans, Martien A. M. Groenen, Hendrik‐Jan Megens
Publikováno v:
Evolutionary Applications, Vol 13, Iss 2, Pp 330-341 (2020)
Abstract Predictions about the consequences of a small population size on genetic and deleterious variation are fundamental to population genetics. As small populations are more affected by genetic drift, purifying selection acting against deleteriou
Externí odkaz:
https://doaj.org/article/c1e18ff390f444e08aa28592dab444e3
Akademický článek
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Akademický článek
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Autor:
Sankar Subramanian
Publikováno v:
BMC Genetics, Vol 20, Iss 1, Pp 1-12 (2019)
Abstract Background It is well known that the effective size of a population (N e ) is one of the major determinants of the amount of genetic variation within the population. However, it is unclear whether the types of genetic variations are also dic
Externí odkaz:
https://doaj.org/article/2ce1e71499bf402ea3a03ca5de497e0c