Zobrazeno 1 - 10
of 49
pro vyhledávání: '"delayed start design"'
Publikováno v:
Contemporary Clinical Trials Communications, Vol 2, Iss C, Pp 34-53 (2016)
The basic problem that causes the frequent failure of a standard randomized parallel placebo-controlled clinical trial with a high placebo response rate is the underestimation of the treatment effect by the observed relative treatment difference. A t
Externí odkaz:
https://doaj.org/article/b070f4e06c35491491102a902570baf4
Publikováno v:
Annali dell'Istituto Superiore di Sanità, Vol 47, Iss 1, Pp 49-54 (2011)
Neurodegenerative diseases are disabling conditions continuously increasing due to aging of population. A disease modifying therapy that slows or stops disease progression is therefore a major unmet medical need. Unfortunately, research for effective
Externí odkaz:
https://doaj.org/article/22812d8f640546f2815666720e08b58b
Publikováno v:
Statistics in Medicine. 37(25):3573-3588
Stepped wedge designs and delayed start designs can all be considered as special cases of the so-called unidirectional switch design. This paper provides optimal proportions of clusters that are allocated to switch patterns in a unidirectional switch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dris___00893::55deacd5ead76fc4024c58e95dae1292
https://doi.org/10.1002/sim.7853
https://doi.org/10.1002/sim.7853
Akademický článek
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Akademický článek
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Publikováno v:
Statistical Methods in Medical Research. 26(2):766-775
This paper compares the power of the parallel group design, the matched-pairs design, and several options for the stepped wedge and delayed start designs for testing a possible effect of intranasal insulin with respect to placebo on developmental gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dris___01180::863e79f88085a24fdd3cb69548636b59
https://doi.org/10.1177/0962280214558864
https://doi.org/10.1177/0962280214558864
Publikováno v:
Statistical Methods in Medical Research. 26(2):766-775
This paper compares the power of the parallel group design, the matched-pairs design, and several options for the stepped wedge and delayed start designs for testing a possible effect of intranasal insulin with respect to placebo on developmental gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c733753a3e2999de53be55031944b72
https://doi.org/10.1177/0962280214558864
https://doi.org/10.1177/0962280214558864
Publikováno v:
Contemporary Clinical Trials Communications, Vol 2, Iss C, Pp 34-53 (2016)
Contemporary Clinical Trials Communications
Contemporary Clinical Trials Communications
The basic problem that causes the frequent failure of a standard randomized parallel placebo-controlled clinical trial with a high placebo response rate is the underestimation of the treatment effect by the observed relative treatment difference. A t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f74126228a369323717bf038118ef1a
Publikováno v:
Statistics in Medicine, 37(25), 3573-3588. Wiley
Stepped wedge designs and delayed start designs can all be considered as special cases of the so-called unidirectional switch design. This paper provides optimal proportions of clusters that are allocated to switch patterns in a unidirectional switch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::75089eebf9293c31011b5fa814906306
https://research.tue.nl/nl/publications/51e4d9ff-27ed-4808-b259-40510e2e511a
https://research.tue.nl/nl/publications/51e4d9ff-27ed-4808-b259-40510e2e511a
Publikováno v:
Statistical Methods in Medical Research, 27(9), 2872-2882. SAGE Publications Ltd
Statistical Methods in Medical Research, 27(9), 2872-2882. SAGE Publications Inc.
Statistical Methods in Medical Research, 27(9), 2872-2882. SAGE Publications Inc.
Clinical trials may apply or use a sequential introduction of a new treatment to determine its efficacy or effectiveness with respect to a control treatment. The reasons for choosing a particular switch design have different origins. For instance, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55617640ec388708ad057a6dfac99073
https://research.tue.nl/nl/publications/1f39aeda-8036-47ac-852e-bbe25474402a
https://research.tue.nl/nl/publications/1f39aeda-8036-47ac-852e-bbe25474402a