A multimodal atlas of hepatocellular carcinoma reveals convergent evolutionary paths and ‘bad apple’ effect on clinical trajectory

Autor: Chen, Jianbin, Kaya, Neslihan Arife, Zhang, Ying, Kendarsari, Raden Indah, Sekar, Karthik, Lee Chong, Shay, Seshachalam, Veerabrahma Pratap, Ling, Wen Huan, Jin Phua, Cheryl Zi, Lai, Hannah, Yang, Hechuan, Lu, Bingxin, Lim, Jia Qi, Ma, Siming, Chew, Sin Chi, Chua, Khi Pin, Santiago Alvarez, Jacob Josiah, Wu, Lingyan, Ooi, London, Yaw-Fui Chung, Alexander, Cheow, Peng Chung, Kam, Juinn Huar, Wei-Chieh Kow, Alfred, Ganpathi, Iyer Shridhar, Bunchaliew, Chairat, Thammasiri, Jidapa, Koh, Peng Soon, Bee-Lan Ong, Diana, Lim, Jasmine, de Villa, Vanessa H., Dela Cruz, Rouchelle D., Loh, Tracy Jiezhen, Wan, Wei Keat, Leow, Wei Qiang, Yang, Yi, Liu, Jin, Skanderup, Anders Jacobsen, Pang, Yin Huei, Ting Soon, Gwyneth Shook, Madhavan, Krishnakumar, Kiat-Hon Lim, Tony, Bonney, Glenn, Goh, Brian K.P., Chew, Valerie, Dan, Yock Young, Toh, Han Chong, Sik-Yin Foo, Roger, Tam, Wai Leong, Zhai, Weiwei, Kah-Hoe Chow, Pierce

Publikováno v: In Journal of Hepatology October 2024 81(4):667-678

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Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in hepatocellular carcinoma: the PLANET study.

Autor: Zhai W; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore 138672, Singapore., Lai H; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore 138672, Singapore., Kaya NA; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore 138672, Singapore., Chen J; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore 138672, Singapore., Yang H; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore 138672, Singapore., Lu B; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore 138672, Singapore., Lim JQ; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore 138672, Singapore., Ma S; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore 138672, Singapore., Chew SC; Division of Surgery and Surgical Oncology, National Cancer Centre, Singapore 169610, Singapore., Chua KP; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore 138672, Singapore., Alvarez JJS; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore 138672, Singapore., Chen PJ; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore 138672, Singapore., Chang MM; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore 138672, Singapore., Wu L; Division of Surgery and Surgical Oncology, National Cancer Centre, Singapore 169610, Singapore., Goh BKP; Department of Hepato-Pancreato-Biliary and Transplant Surgery, Singapore General Hospital, Singapore 169608, Singapore., Chung AY; Department of Hepato-Pancreato-Biliary and Transplant Surgery, Singapore General Hospital, Singapore 169608, Singapore., Chan CY; Department of Hepato-Pancreato-Biliary and Transplant Surgery, Singapore General Hospital, Singapore 169608, Singapore., Cheow PC; Department of Hepato-Pancreato-Biliary and Transplant Surgery, Singapore General Hospital, Singapore 169608, Singapore., Lee SY; Department of Hepato-Pancreato-Biliary and Transplant Surgery, Singapore General Hospital, Singapore 169608, Singapore., Kam JH; Department of Hepato-Pancreato-Biliary and Transplant Surgery, Singapore General Hospital, Singapore 169608, Singapore., Kow AW; Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, University Surgical Cluster, National University Health System, Singapore 119228, Singapore., Ganpathi IS; Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, University Surgical Cluster, National University Health System, Singapore 119228, Singapore., Chanwat R; Hepato-Pancreato-Biliary Surgery Unit, Department of Surgery, National Cancer Institute, Bangkok 10310, Thailand., Thammasiri J; Division of Pathology, National Cancer Institute, Bangkok 10400, Thailand., Yoong BK; Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur 59100, Malaysia., Ong DB; Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur 59100, Malaysia., de Villa VH; Department of Surgery and Center for Liver Disease Management and Transplantation, The Medical City, Pasig City, Metro Manila, Philippines., Dela Cruz RD; Department of Laboratories, The Medical City, Pasig City, Metro Manila, Philippines., Loh TJ; Department of Pathology, Singapore General Hospital, Singapore 169608, Singapore., Wan WK; Department of Pathology, Singapore General Hospital, Singapore 169608, Singapore., Zeng Z; Institute for Infocomm Research, ASTAR, Singapore 138632, Singapore., Skanderup AJ; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore 138672, Singapore., Pang YH; Department of Pathology, National University Health System, Singapore 119228, Singapore., Madhavan K; Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, University Surgical Cluster, National University Health System, Singapore 119228, Singapore., Lim TK; Department of Pathology, Singapore General Hospital, Singapore 169608, Singapore., Bonney G; Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, University Surgical Cluster, National University Health System, Singapore 119228, Singapore., Leow WQ; Department of Pathology, Singapore General Hospital, Singapore 169608, Singapore., Chew V; Translational Immunology Institute (TII), SingHealth Duke-NUS Academic Medical Centre, Singapore 168753, Singapore., Dan YY; Division of Gastroenterology and Hepatology, University Medicine Cluster, National University Hospital, Singapore 119228, Singapore., Tam WL; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore 138672, Singapore., Toh HC; Division of Medical Oncology, National Cancer Center Singapore, Singapore 169610, Singapore., Foo RS; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore 138672, Singapore., Chow PK; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore 138672, Singapore.

Publikováno v: National science review [Natl Sci Rev] 2021 Oct 29; Vol. 9 (3), pp. nwab192. Date of Electronic Publication: 2021 Oct 29 (Print Publication: 2022).