Cases of endophthalmitis caused by Candida albicans and Candida dubliniensis identified via internal transcribed spacer deep sequencing

Autor: Kazunobu Asao, Noriyasu Hashida, Kazuichi Maruyama, Daisuke Motooka, Shota Nakamura, Kohji Nishida

Publikováno v: BMC Ophthalmology, Vol 24, Iss 1, Pp 1-8 (2024)

Abstract Background We report two cases of fungal endophthalmitis induced by Candida species identified based on internal transcribed spacer 1 (ITS1) sequencing. Case presentation In two cases, endophthalmitis was suspected, and the patients underwen

Externí odkaz: https://doaj.org/article/94392de760064c9491c8082b07d5ff36

Native and tagged CENP-A histones are functionally inequivalent

Autor: Minh Bui, Songjoon Baek, Reda S. Bentahar, Daniël P. Melters, Yamini Dalal

Publikováno v: Epigenetics & Chromatin, Vol 17, Iss 1, Pp 1-15 (2024)

Abstract Background Over the past several decades, the use of biochemical and fluorescent tags has elucidated mechanistic and cytological processes that would otherwise be impossible. The challenging nature of certain nuclear proteins includes low ab

Externí odkaz: https://doaj.org/article/19de9942344745358a8999691b1518a9

Predictive genomic and transcriptomic analysis on endoscopic ultrasound-guided fine needle aspiration materials from primary pancreatic adenocarcinoma: a prospective multicentre studyResearch in context

Autor: Rémy Nicolle, Cindy Canivet, Laurent Palazzo, Bertrand Napoléon, Mira Ayadi, Camille Pignolet, Jérôme Cros, Sophie Gourgou, Janick Selves, Jérôme Torrisani, Nelson Dusetti, Pierre Cordelier, Louis Buscail, Barbara Bournet, Nicolas Carrère, Fabrice Muscari, Bertrand Suc, Rosine Guimbaud, Corinne Couteau, Marion Deslandres, Pascale Rivera, Emily Alouany, Nadim Fares, Karl Barange, Anne Gomez-Brouchet, Adrian Culetto, Guillaume Le Cosquer, Marion Jaffrelot, Bertrand Pujol, Fabien Fumex, Jérôme Desrame, Christine Lefort, Vincent Lepilliez, Rodica Gincul, Pascal Artru, Léa Clavel, Anne-Isabelle Lemaistre, Sarah Tubiana, Nicolas Flori, Pierre Senesse, Pierre-Emmanuel Colombo, Emmanuelle Samalin-Scalzi, Fabienne Portales, Lise Roca, Claire Honfo Ga, Carinne Plassot, Marc Ychou, Pierre Guibert, Christelle De La Fouchardière, Mathieu Sarabi, Patrice Peyrat, Séverine Tabone-Eglinger, Caroline Renard, Guillaume Piessen, Stéphanie Truant, Alain Saudemont, Guillaume Millet, Florence Renaud, Emmanuelle Leteurtre, Patrick Gelé, Eric Assenat, Jean-Michel Fabre, François-Régis Souche, Marie Dupuy, Anne-Marie Gorce-Dupuy, Jeanne Ramos, Jean-François Seitz, Jean Hardwigsen, Emmanuelle Norguet-Monnereau, Philippe Grandval, Muriel Duluc, Dominique Figarella-Branger, Véronique Vendrely, Clément Subtil, Eric Terrebonne, Jean-Frédéric Blanc, Jean-Philippe Merlio, Dominique Farges-Bancel, Jean-Marc Gornet, Daniela Geromin, Geoffroy Vanbiervliet, Anne-Claire Frin, Delphine Ouvrier, Marie-Christine Saint-Paul, Philippe Berthélémy, Chelbabi Fouad, Stéphane Garcia, Nathalie Lesavre, Mohamed Gasmi, Marc Barthet, Vanessa Cottet, Cyrille Delpierre

Publikováno v: EBioMedicine, Vol 109, Iss , Pp 105373- (2024)

Summary: Background: We apply endoscopic ultrasound-guided fine needle aspiration biopsy to cytopathologically diagnose and sample nucleic acids from primary tumours regardless of the disease stage. Methods: 397 patients with proven pancreatic adenoc

Externí odkaz: https://doaj.org/article/42b1e90f321d4eb681ad93fd73b2d3f5

Molecular detection of exosomal miRNAs of blood serum for prognosis of colorectal cancer

Autor: Tahani Bakhsh, Safiah Alhazmi, Ali Farsi, Abdulaziz S. Yusuf, Amani Alharthi, Safa H. Qahl, Maha Ali Alghamdi, Faisal A. Alzahrani, Ola H. Elgaddar, Mohanad A. Ibrahim, Ahmed Bahieldin

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-21 (2024)

Abstract Colorectal cancer (CRC) is the third most common cancer affecting people. The discovery of new, non-invasive, specific, and sensitive molecular biomarkers for CRC may assist in the diagnosis and support therapeutic decision making. Exosomal

Externí odkaz: https://doaj.org/article/2f5ac08bbc2c4f7a821b5ee7a54569df

The rise of big data: deep sequencing-driven computational methods are transforming the landscape of synthetic antibody design

Autor: Eugenio Gallo

Publikováno v: Journal of Biomedical Science, Vol 31, Iss 1, Pp 1-19 (2024)

Abstract Synthetic antibodies (Abs) represent a category of artificial proteins capable of closely emulating the functions of natural Abs. Their in vitro production eliminates the need for an immunological response, streamlining the process of Ab dis

Externí odkaz: https://doaj.org/article/b434980509e24be2871ca33b2faae13e