Zobrazeno 1 - 10
of 673
pro vyhledávání: '"deep mutational scanning"'
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-19 (2024)
Abstract Adeno-associated viruses 2 (AAV2) are minute viruses renowned for their capacity to infect human cells and akin organisms. They have recently emerged as prominent candidates in the field of gene therapy, primarily attributed to their inheren
Externí odkaz:
https://doaj.org/article/553499d5eb064011adeae295355f32b3
Autor:
Alexander F McDonnell, Marcin Plech, Benjamin J Livesey, Lukas Gerasimavicius, Liusaidh J Owen, Hildegard Nikki Hall, David R FitzPatrick, Joseph A Marsh, Grzegorz Kudla
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 7, Pp 825-844 (2024)
Abstract Nonsense and missense mutations in the transcription factor PAX6 cause a wide range of eye development defects, including aniridia, microphthalmia and coloboma. To understand how changes of PAX6:DNA binding cause these phenotypes, we combine
Externí odkaz:
https://doaj.org/article/46f6b432ee554b1bbff01429fb10cdbb
Autor:
Alexandra M Bendel, Kristjana Skendo, Dominique Klein, Kenji Shimada, Kotryna Kauneckaite-Griguole, Guillaume Diss
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-16 (2024)
Abstract Deep Mutational Scanning (DMS) assays are powerful tools to study sequence-function relationships by measuring the effects of thousands of sequence variants on protein function. During a DMS experiment, several technical artefacts might dist
Externí odkaz:
https://doaj.org/article/1fb594eb28444d5ba39c36f144ec3f1c
Publikováno v:
eLife, Vol 13 (2024)
Evolutionary arms races can arise at the contact surfaces between host and viral proteins, producing dynamic spaces in which genetic variants are continually pursued. However, the sampling of genetic variation must be balanced with the need to mainta
Externí odkaz:
https://doaj.org/article/6d939e365f7a4bc7991e4d0e1ac6be3a
Autor:
Gabriella O Estevam, Edmond M Linossi, Christian B Macdonald, Carla A Espinoza, Jennifer M Michaud, Willow Coyote-Maestas, Eric A Collisson, Natalia Jura, James S Fraser
Publikováno v:
eLife, Vol 12 (2024)
MET is a receptor tyrosine kinase (RTK) responsible for initiating signaling pathways involved in development and wound repair. MET activation relies on ligand binding to the extracellular receptor, which prompts dimerization, intracellular phosphory
Externí odkaz:
https://doaj.org/article/b6001b942b874658867de1b8cb4e8907
Autor:
Melina Claussnitzer, Victoria N. Parikh, Alex H. Wagner, Jeremy A. Arbesfeld, Carol J. Bult, Helen V. Firth, Lara A. Muffley, Alex N. Nguyen Ba, Kevin Riehle, Frederick P. Roth, Daniel Tabet, Benedetta Bolognesi, Andrew M. Glazer, Alan F. Rubin
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-8 (2024)
Abstract Multiplexed assays of variant effect (MAVEs) have emerged as a powerful approach for interrogating thousands of genetic variants in a single experiment. The flexibility and widespread adoption of these techniques across diverse disciplines h
Externí odkaz:
https://doaj.org/article/ee5b2abbc9bf4533aed98196fa9861b1
Autor:
Victoria I. Bunik
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
Externí odkaz:
https://doaj.org/article/798316d8703b4603a7127ff76953728f
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
B cells surveil the body for foreign matter using their surface-expressed B cell antigen receptor (BCR), a tetrameric complex comprising a membrane-tethered antibody (mIg) that binds antigens and a signaling dimer (CD79AB) that conveys this interacti
Externí odkaz:
https://doaj.org/article/01e0ede57de04b9e9e729f528e89d11f
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 6 (2024)
Externí odkaz:
https://doaj.org/article/ea8ccd7d841840ddbf7be63eb0a4d03b
Publikováno v:
eLife, Vol 12 (2024)
A protein’s genetic architecture – the set of causal rules by which its sequence produces its functions – also determines its possible evolutionary trajectories. Prior research has proposed that the genetic architecture of proteins is very comp
Externí odkaz:
https://doaj.org/article/322993c1c1ed478d814735598c95cd5f