Zobrazeno 1 - 10
of 1 143
pro vyhledávání: '"decoy receptor"'
Autor:
Savanna Skeeters, Kamal Bagale, Galina Stepanyuk, David Thieker, Aaron Aguhob, Kui K. Chan, Benjamin Dutzar, Sergei Shalygin, Asif Shajahan, Xu Yang, Paul A. DaRosa, Emily Frazier, Maximilian M. Sauer, Lisa Bogatzki, Kelly A. Byrnes-Blake, Yifan Song, Parastoo Azadi, Eric Tarcha, Lianghui Zhang, Erik Procko
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 3, Pp 101301- (2024)
The Spike of SARS-CoV-2 recognizes a transmembrane protease, angiotensin-converting enzyme 2 (ACE2), on host cells to initiate infection. Soluble derivatives of ACE2, in which Spike affinity is enhanced and the protein is fused to Fc of an immunoglob
Externí odkaz:
https://doaj.org/article/b2b2bd2891874b01b757aa1d70d24fa4
Publikováno v:
陆军军医大学学报, Vol 46, Iss 5, Pp 484-490 (2024)
Objective To investigate the correlation between decoy receptor 2 (DcR2) and clinical indicators and pathological damage in patients with acute kidney injury (AKI). Methods A total of 51 AKI patients diagnosed with renal biopsy and 20 healthy control
Externí odkaz:
https://doaj.org/article/abb96a98716a42419769426b19a08dd8
Autor:
Jingqian Su, Wenzhi Chen, Fen Zhou, Rui Li, Zhiyong Tong, Shun Wu, Zhen Ye, Yichao Zhang, Ben Lin, Xing Yu, Biyun Guan, Zhihua Feng, Kunsen Chen, Qi Chen, Long Chen
Publikováno v:
mBio, Vol 15, Iss 6 (2024)
ABSTRACT Despite its high mortality, specific and effective drugs for sepsis are lacking. Decoy receptor 3 (DcR3) is a potential biomarker for the progression of inflammatory diseases. The recombinant human DcR3-Fc chimera protein (DcR3.Fc) suppresse
Externí odkaz:
https://doaj.org/article/afb8cfd3125c4bd49ecb4247a5f5d89b
Publikováno v:
Nefrología (English Edition), Vol 43, Iss 3, Pp 344-350 (2023)
Introduction: The cardiovascular risk has been increased in chronic kidney disease associated with chronic inflammation and atherosclerosis. Decoy receptor 3, is a member of the TNF receptor superfamily and associated with inflammation and atheroscle
Externí odkaz:
https://doaj.org/article/e7fa64e0f7c74a9e97d67f479de36e24
Autor:
Sven H. Petersen, Kays Al Badawy, Richard Hopkins, Dang L. Vu, Mehran Rahmani, Sonia M.P. Maia, John E. Connolly
Publikováno v:
Molecular Therapy: Oncolytics, Vol 31, Iss , Pp 100730- (2023)
Transforming growth factor β (TGF-β) is a pleiotropic cytokine expressed by a wide range of cell types and is known for hampering the effectiveness of cancer immune cell therapeutic approaches. We have designed a novel construct containing the extr
Externí odkaz:
https://doaj.org/article/83027325b8ec46cd8570a044c90ebe39
Autor:
William M. Pardridge
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
Parkinson’s disease (PD) is characterized by neurodegeneration of nigral-striatal neurons in parallel with the formation of intra-neuronal α-synuclein aggregates, and these processes are exacerbated by neuro-inflammation. All 3 components of PD pa
Externí odkaz:
https://doaj.org/article/efb8bef39da14e3489ae7e4319e22b58
Autor:
Bolun Wang, Junxuan Zhao, Shuo Liu, Jingyuan Feng, Yufeng Luo, Xinyu He, Yanmin Wang, Feixiang Ge, Junyi Wang, Buqing Ye, Weijin Huang, Xiaochen Bo, Youchun Wang, Jianzhong Jeff Xi
Publikováno v:
Emerging Microbes and Infections, Vol 11, Iss 1, Pp 1488-1499 (2022)
The recent global pandemic was a spillover from the SARS-CoV-2 virus. Viral entry involves the receptor binding domain (RBD) of the viral spike protein interacting with the protease domain (PD) of the cellular receptor, ACE2. We hereby present a comp
Externí odkaz:
https://doaj.org/article/4d718cb00c0d4fdba291a6aacbfa40b9
Akademický článek
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Akademický článek
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Autor:
Wenlin Ren, Yu Zhang, Juhong Rao, Ziyi Wang, Jun Lan, Kunpeng Liu, Xuekai Zhang, Xue Hu, Chen Yang, Guocai Zhong, Rong Zhang, Xinquan Wang, Chao Shan, Qiang Ding
Publikováno v:
mBio, Vol 14, Iss 2 (2023)
ABSTRACT Recently, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant B.1.1.529 (Omicron) has rapidly become the dominant strain, with an unprecedented number of mutations within its spike gene. However, it remains unknown whether t
Externí odkaz:
https://doaj.org/article/c91c990f4ee744818ee4b604cf5612df