Nuclear Factor-κB Decoy Oligodeoxynucleotide Attenuates Cartilage Resorption In Vitro

Autor: Hitoshi Nemoto, Daisuke Sakai, Deborah Watson, Koichi Masuda

Publikováno v: Bioengineering, Vol 11, Iss 1, p 46 (2024)

Background: Cartilage harvest and transplantation is a common surgery using costal, auricular, and septal cartilage for craniofacial reconstruction. However, absorption and warping of the cartilage grafts can occur due to inflammatory factors associa

Externí odkaz: https://doaj.org/article/ff6bcde018dd4d4a92189d0af8203f61

The Effects of Synthetic SREBP-1 and PPAR-γ Decoy Oligodeoxynucleotide on Acne-like Disease In Vivo and In Vitro via Lipogenic Regulation

Autor: Hyemin Gu, Hyun-Jin An, Mi-Gyeong Gwon, Seongjae Bae, Christos C. Zouboulis, Kwan-Kyu Park

Publikováno v: Biomolecules, Vol 12, Iss 12, p 1858 (2022)

Acne vulgaris has a pathogenesis that involves increased sebum production and perifollicular inflammation. Sterol regulatory element-binding protein-1 (SREBP-1) and peroxisome proliferator activated receptor-γ (PPAR-γ) are transcription factors tha

Externí odkaz: https://doaj.org/article/24a9c69aa50f4a47996dc71be469acba

Prevention of Asthma Exacerbation in a Mouse Model by Simultaneous Inhibition of NF-κB and STAT6 Activation Using a Chimeric Decoy Strategy

Autor: Tetsuo Miyake, Takashi Miyake, Makoto Sakaguchi, Hirokazu Nankai, Takahiro Nakazawa, Ryuichi Morishita

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 10, Iss , Pp 159-169 (2018)

Transactivation of inflammatory and immune mediators in asthma is tightly regulated by nuclear factor κB (NF-κB) and signal transducer and activator of transcription 6 (STAT6). Therefore, we investigated the efficacy of simultaneous inhibition of N

Externí odkaz: https://doaj.org/article/d76b4abf12514741820129bbb16b2278

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Recent trends of NFκB decoy oligodeoxynucleotide-based nanotherapeutics in lung diseases

Autor: Peter Wich, Quian Peter Su, Vipan K. Parihar, Keshav Raj Paudel, Philip M. Hansbro, Vinod Kumar Kannaujiya, Kamal Dua, Meenu Mehta, Niraj Kumar Jha, Venkata Sita Rama Raju Allam, Amlan Chakraborty, Amlan Das, Nisha Panth, Shakti D. Shukla, Jon Adams, Dikaia Xenaki, Dinesh Kumar Chellappan, Khadem Ali, Brian G. Oliver

Publikováno v: Mehta, M, Paudel, K R, Shukla, S D, Allam, V S R R, Kannaujiya, V K, Panth, N, Das, A, Parihar, V K, Chakraborty, A, Ali, M K, Jha, N K, Xenaki, D, Su, Q P, Wich, P R, Adams, J, Hansbro, P M, Chellappan, D K, Oliver, B G G & Dua, K 2021, ' Recent trends of NFkB decoy oligodeoxynucleotide-based nanotherapeutics in lung diseases ', Journal of Controlled Release, vol. 337, pp. 629-644 . https://doi.org/10.1016/j.jconrel.2021.08.010

Nuclear factor κB (NFκB) is a unique protein complex that plays a major role in lung inflammation and respiratory dysfunction. The NFκB signaling pathway, therefore becomes an avenue for the development of potential pharmacological interventions,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::800b91932a21a54caf3abe5becfd0839
https://pubmed.ncbi.nlm.nih.gov/34375688