Zobrazeno 1 - 10
of 649
pro vyhledávání: '"death-associated protein 6"'
Autor:
Sung-Min Kim, Won-Hee Hur, Byung-Yoon Kang, Sung-Won Lee, Pu-Reun Roh, Dong-Jun Park, Pil-Soo Sung, Seung-Kew Yoon
Publikováno v:
Cells, Vol 10, Iss 7, p 1742 (2021)
Transforming growth factor-β (TGF-β) has been identified as an inducer of hepatocyte epithelial–mesenchymal transition (EMT), which triggers liver fibrosis. Death-associated protein 6 (Daxx) is known to be associated with the TGF-β-induced apopt
Externí odkaz:
https://doaj.org/article/1520a5fd9e724b83b7221d7359bf01e7
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:1585-1592
Tyrosine kinase 2 (Tyk2) is a member of the Janus family of protein tyrosine kinases (Jaks). Tyk2 associates with interferon (IFN)-α, IFN-β, interleukin (IL)-6, IL-10, IL-12, and IL-23 receptors and mediates their downstream signaling pathways. Bas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20f8ce2048df228ae684a00291d4a2e9
https://doi.org/10.1248/bpb.b21-00609
https://doi.org/10.1248/bpb.b21-00609
Autor:
Guixin Zhu, Ronen Marmorstein, Xiaolu Yang, Liming Tao, JiaBei Lin, Trisha Agrawal, Sixiang Yu, Liangqian Huang, James Shorter
Publikováno v:
Nature. 597:132-137
Protein quality control systems are crucial for cellular function and organismal health. At present, most known protein quality control systems are multicomponent machineries that operate via ATP-regulated interactions with non-native proteins to pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c510382f88abb2dc24fa9f993920f15
https://doi.org/10.1038/s41586-021-03824-5
https://doi.org/10.1038/s41586-021-03824-5
Autor:
Muhammet Nafi Civan, Ahmet Bekar, Mevlut Ozgur Taskapilioglu, Omer Gokay Argadal, Pinar Eser Ocak, Secil Ak Aksoy, Ismail Seckin Kaya, Sahsine Tolunay, Cagla Tekin, Melis Mutlu, Berrin Tunca, Hasan Kocaeli
Publikováno v:
Neurological Research. 43:916-925
Objective: This study was designed to conduct molecular classification based on IDH1/2, TERT, ATRX, and DAXX changes in pediatric and adult primary glioblastoma (GB) and to analyze the potential interaction of LncRNA MALAT1 in the determined homogene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::144b3addcffb29b04bf7ce960349cef4
https://doi.org/10.1080/01616412.2021.1948738
https://doi.org/10.1080/01616412.2021.1948738
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-4 (2021)
The PCAWG Consortium has recently released an unprecedented set of tumor whole genome sequence (WGS) data from 2,658 cancer patients across 38 different primary tumor sites1. WGS is able to document the quantity and distribution of telomeric repeats2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcaa8e4d99ee4ea9a68ee88576440a18
https://doaj.org/article/d925a76ff46a4b74bb89120223902ae9
https://doaj.org/article/d925a76ff46a4b74bb89120223902ae9
Autor:
Valentina Loi, Didier Portilla, Sundararaman Swaminathan, Yogesh Scindia, Elizabeth Ghias, Ewa Wlazlo, Sylvia Cechova, Joseph Leeds, Jonathan Ledesma
Publikováno v:
Am J Physiol Renal Physiol
Acute kidney injury (AKI) is a frequent complication of sepsis and an important cause of morbidity and mortality worldwide. A cornerstone of sepsis-associated AKI is dysregulated inflammation, leading to increased tissue oxidative stress and free rad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4e617a29f54807514d6de3ac7dc892d
https://doi.org/10.1152/ajprenal.00064.2020
https://doi.org/10.1152/ajprenal.00064.2020
Publikováno v:
npj Breast Cancer, Vol 6, Iss 1, Pp 1-12 (2020)
NPJ Breast Cancer
NPJ Breast Cancer
Recurrence of estrogen receptor (ER)-positive breast tumors despite curative-intent adjuvant therapy is thought to be due to enrichment of tumor initiating cells (TIC) during endocrine therapy (ET). Recently, it was identified that by antagonizing th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e50e8f7d19cb18651750e9b509da4b9f
http://link.springer.com/article/10.1038/s41523-020-00178-5
http://link.springer.com/article/10.1038/s41523-020-00178-5
Autor:
Christine Davis, Sandro Santagata, Fausto J. Rodriguez, Gary L. Gallia, Wenya Linda Bi, Christopher M. Heaphy, Shannon Coy
Publikováno v:
Mod Pathol
Telomeres are nucleoprotein complexes located at the termini of eukaryotic chromosomes that prevent exonucleolytic degradation and end-to-end chromosomal fusions. Cancers often have critically shortened, dysfunctional telomeres contributing to genomi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bd04733111cffd674e83c3beec1f97a
https://doi.org/10.1038/s41379-020-0523-2
https://doi.org/10.1038/s41379-020-0523-2
Publikováno v:
Virchows Archiv
The objective of this study was to analyze the expression and clinical role of mitosis regulators α-thalassemia/mental retardation syndrome X-linked (ATRX) and death-domain-associated protein (DAXX) in metastatic high-grade serous carcinoma (HGSC).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1f59b19432cda1baf10b860308587d6
https://doi.org/10.1007/s00428-020-02842-4
https://doi.org/10.1007/s00428-020-02842-4
Autor:
Koen M.A. Dreijerink, Charlotte M. Heidsma, Wenzel M. Hackeng, G. Johan A. Offerhaus, Willemien Schelhaas, Susanne van Eeden, Lodewijk A.A. Brosens, Gerlof D. Valk, Folkert H.M. Morsink, Christopher M. Heaphy, Menno R. Vriens, Els J. M. Nieveen van Dijkum
Publikováno v:
Endocrine Pathology, 31(2), 108-118. Humana Press
Endocrine Pathology
Hackeng, W M, Schelhaas, W, Morsink, F H M, Heidsma, C M, van Eeden, S, Valk, G D, Vriens, M R, Heaphy, C M, Nieveen van Dijkum, E J M, Offerhaus, G J A, Dreijerink, K M A & Brosens, L A A 2020, ' Alternative Lengthening of Telomeres and Differential Expression of Endocrine Transcription Factors Distinguish Metastatic and Non-metastatic Insulinomas ', Endocrine Pathology, vol. 31, no. 2, pp. 108-118 . https://doi.org/10.1007/s12022-020-09611-8
Endocrine Pathology
Hackeng, W M, Schelhaas, W, Morsink, F H M, Heidsma, C M, van Eeden, S, Valk, G D, Vriens, M R, Heaphy, C M, Nieveen van Dijkum, E J M, Offerhaus, G J A, Dreijerink, K M A & Brosens, L A A 2020, ' Alternative Lengthening of Telomeres and Differential Expression of Endocrine Transcription Factors Distinguish Metastatic and Non-metastatic Insulinomas ', Endocrine Pathology, vol. 31, no. 2, pp. 108-118 . https://doi.org/10.1007/s12022-020-09611-8
Insulin-producing pancreatic neuroendocrine tumors (PanNETs)/insulinomas are generally considered to be indolent tumors with an excellent prognosis after complete resection. However, some insulinomas have a poor prognosis due to relapses and metastat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fba1a951a08019835aa2bbc6ccc317a9
https://doi.org/10.1007/s12022-020-09611-8
https://doi.org/10.1007/s12022-020-09611-8