Structure Guided Discovery of Novel Pan Metallo-β-Lactamase Inhibitors with Improved Gram-Negative Bacterial Cell Penetration.

Autor: Dong S; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Zhao Z; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Tang H; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Li G; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Pan J; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Gu X; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Jiang J; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Xiao L; Computational and Structural Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Scapin G; Computational and Structural Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Hunter DN; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Yang D; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Huang Y; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Bennett F; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Yang SW; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Mandal M; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Tang H; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Su J; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Tudge C; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., deJesus RK; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Ding FX; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Lombardo M; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Hicks JD; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Fischmann T; Computational and Structural Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Mirza A; Antibacterial/Antifungal, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Dayananth P; Quantitative Biosciences, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Painter RE; Quantitative Biosciences, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Villafania A; Quantitative Biosciences, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Garlisi CG; Quantitative Biosciences, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Zhang R; Quantitative Biosciences, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Mayhood TW; Quantitative Biosciences, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Si Q; Quantitative Biosciences, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Li N; Nonclinical Drug Safety, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Amin RP; Nonclinical Drug Safety, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Bhatt B; Nonclinical Drug Safety, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Chen F; Nonclinical Drug Safety, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Regan CP; Nonclinical Drug Safety, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Regan H; Nonclinical Drug Safety, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Lin X; Pharmacokinetics Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Wu J; Pharmacokinetics Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Leithead A; Discovery Pharmaceutical Sciences, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Pollack SR; Discovery Process Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Scott JD; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Nargund RP; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Therien AG; Exploratory Science Center, Merck & Co., Inc., Cambridge, Massachusetts 02139, United States., Black T; Antibacterial/Antifungal, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Young K; Antibacterial/Antifungal, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Pasternak A; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Mar 14; Vol. 67 (5), pp. 3400-3418. Date of Electronic Publication: 2024 Feb 22.