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Akademický článek

Chronic inflammation with microglia senescence at basal forebrain: impact on cholinergic deficit in Alzheimer's brain haemodynamics.

Autor: Liu D; Drug Design & Development Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA., Hsueh SC; Drug Design & Development Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.; Department of Pediatrics, Columbia University Irving Medical Center, Columbia University Vagelos Physicians & Surgeons College of Medicine, New York City, NY 10032, USA., Tweedie D; Drug Design & Development Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA., Price N; Experimental Gerontology Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA., Glotfelty E; Drug Design & Development Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.; Department of Neuroscience, Karolinska Institute, Stockholm 17177, Sweden.; Cellular Stress and Inflammation Section, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA., Lecca D; Drug Design & Development Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.; Shock, Trauma & Anesthesiology Research Center, University of Maryland, Baltimore, MD 21201, USA., Telljohann R; Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA., deCabo R; Department of Pediatrics, Columbia University Irving Medical Center, Columbia University Vagelos Physicians & Surgeons College of Medicine, New York City, NY 10032, USA., Hoffer BJ; Department of Neurosurgery, Case Western Reserve University School of Medicine, University Hospitals, Cleveland, OH 44106, USA., Greig NH; Drug Design & Development Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.

Publikováno v: Brain communications [Brain Commun] 2024 Jun 12; Vol. 6 (4), pp. fcae204. Date of Electronic Publication: 2024 Jun 12 (Print Publication: 2024).

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Akademický článek

The effects of age and lipopolysaccharide (LPS)-mediated peripheral inflammation on numbers of central catecholaminergic neurons

Autor: Mouton, P.R., Kelley-Bell, B., Tweedie, D., Spangler, E.L., Perez, E., Carlson, O.D., Short, R.G., deCabo, R., Chang, J., Ingram, D.K., Li, Y., Greig, N.H.

Publikováno v: In Neurobiology of Aging February 2012 33(2):423-423

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Find drugs that delay many diseases of old age

Autor: Bellantuono, I., DeCabo, R., Ehninger, D., Fernandes, A., Howlett, S.E., Müller, R., Potter, P., Tchkonia, T., Trendelenburg, A.-U., Trejo, J.L., Vandenbroucke, R., van Os, R., van Riel, N.A.W.

Publikováno v: Nature, 554(7692), 293-295. Nature Publishing Group

Simply extending lifespan is not enough. We need treatments that boost resilience to multiple age-related diseases, argue Ilaria Bellantuono and 12 co-signatories. Simply extending lifespan is not enough. We need treatments that boost resilience to m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb920f87e5f370bc6ac071153645c0d8
https://pubmed.ncbi.nlm.nih.gov/29446384

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Akademický článek

Early life interventions metformin and trodusquemine metabolically reprogram the developing mouse liver through transcriptomic alterations.

Autor: Ashiqueali, Sarah A.¹ (AUTHOR), Schneider, Augusto² (AUTHOR), Zhu, Xiang¹ (AUTHOR), Juszczyk, Ewelina³ (AUTHOR), Mansoor, Mishfak A. M.¹ (AUTHOR), Zhu, Yun⁴ (AUTHOR), Fang, Yimin⁴ (AUTHOR), Zanini, Bianka M.² (AUTHOR), Garcia, Driele N.² (AUTHOR), Hayslip, Natalie¹ (AUTHOR), Medina, David⁴ (AUTHOR), McFadden, Samuel⁴ (AUTHOR), Stockwell, Robert⁴ (AUTHOR), Yuan, Rong⁴ (AUTHOR), Bartke, Andrzej⁴ (AUTHOR), Zasloff, Michael⁵ (AUTHOR), Siddiqi, Shadab¹ (AUTHOR), Masternak, Michal M.^1,6 (AUTHOR) michal.masternak@ucf.edu

Publikováno v: Aging Cell. Sep2024, Vol. 23 Issue 9, p1-22. 22p.

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Akademický článek

Resveratrol and Vitamin D: Eclectic Molecules Promoting Mitochondrial Health in Sarcopenia.

Autor: Russo, Cristina¹ (AUTHOR) cristina.russo@unict.it, Valle, Maria Stella² (AUTHOR) m.valle@unict.it, D'Angeli, Floriana³ (AUTHOR) floriana.dangeli@uniroma5.it, Surdo, Sofia⁴ (AUTHOR) s.surdo98@yahoo.com, Malaguarnera, Lucia¹ (AUTHOR) lucmal@unict.it

Publikováno v: International Journal of Molecular Sciences. Jul2024, Vol. 25 Issue 14, p7503. 22p.

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The effects of age and LPS-mediated peripheral inflammation on numbers of central catecholaminergic neurons

Autor: Mouton, P.R., Kelley-Bell, B., Tweedie, D., Spangler, E.L, Perez, E., Carlson, O.D., Short, R.G., deCabo, R., Chang, J., Ingram, D.K., Li, Y., Greig, N.H.

Parkinson's disease (PD), an age-related movement disorder, is characterized by severe catecholaminergic neuron loss in the substantia nigra pars compacta (SN(PC))-ventral tegmental area (VTA) and locus coeruleus (LC). To assess the stability of thes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c7392597c0a167dfa4631b11b641351c
https://europepmc.org/articles/PMC3116956/

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Akademický článek

Decreasing Intracellular Entropy by Increasing Mitochondrial Efficiency and Reducing ROS Formation—The Effect on the Ageing Process and Age-Related Damage.

Autor: Poljšak, Borut¹ (AUTHOR) borut.poljsak@zf.uni-lj.si, Milisav, Irina^1,2 (AUTHOR) irina.milisav@mf.uni-lj.si

Publikováno v: International Journal of Molecular Sciences. Jun2024, Vol. 25 Issue 12, p6321. 24p.

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Akademický článek

Caloric Restriction Mimetics Slow Aging of Neuromuscular Synapses and Muscle Fibers.

Autor: Stockinger J; Virginia Tech Carilion Research Institute, Roanoke College, Virginia.; Department of Biology, Roanoke College, Virginia., Maxwell N; Virginia Tech Carilion Research Institute, Roanoke College, Virginia., Shapiro D; Virginia Tech Carilion Research Institute, Roanoke College, Virginia., deCabo R; Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, Maryland., Valdez G; Virginia Tech Carilion Research Institute, Roanoke College, Virginia.; Department of Biological Sciences, Virginia Tech.

Publikováno v: The journals of gerontology. Series A, Biological sciences and medical sciences [J Gerontol A Biol Sci Med Sci] 2017 Dec 12; Vol. 73 (1), pp. 21-28.

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