Zobrazeno 1 - 10
of 2 871
pro vyhledávání: '"de novo lipogenesis"'
Autor:
Huanxian Cui, Yongli Wang, Yuting Zhu, Xiaojing Liu, Lu Liu, Jie Wang, Xiaodong Tan, Yidong Wang, Siyuan Xing, Na Luo, Li Liu, Ranran Liu, Maiqing Zheng, Guiping Zhao, Jie Wen
Publikováno v:
Journal of Advanced Research, Vol 65, Iss , Pp 19-31 (2024)
Introduction: The proportion of animal based foods in daily diet of consumers is constantly increasing, with chicken being highly favored due to its high protein and low fat characteristics. The consumption of chicken around the world is steadily inc
Externí odkaz:
https://doaj.org/article/51f4a3f37da9413e86e4aaa20e0128d9
Autor:
Yang Song, Wei Zhong, Harry Cheuk-Hay Lau, Yating Zhang, Huayu Guan, Mingxu Xie, Suki Ha, Diwen Shou, Yongjian Zhou, Hongzhi Xu, Jun Yu, Xiang Zhang
Publikováno v:
Engineering, Vol 41, Iss , Pp 204-215 (2024)
Carboxyl ester lipase (CEL), a pivotal enzyme involved in lipid metabolism, is recurrently mutated in obese mice. Here, we aimed to elucidate the functional significance, molecular mechanism, and therapeutic potential of CEL in metabolic dysfunction-
Externí odkaz:
https://doaj.org/article/cee61af6a9e2452aa805d19c15d00b50
Publikováno v:
Journal of Experimental Pharmacology, Vol Volume 16, Pp 351-364 (2024)
Putri Anggreini,1,2,* Hadi Kuncoro,2,* Sri Adi Sumiwi,3,* Jutti Levita3,* 1Doctoral Program in Pharmacy, Faculty of Pharmacy, Padjadjaran University, Sumedang, West Java, Indonesia; 2Department of Pharmacognosy and Medicinal Chemistry
Externí odkaz:
https://doaj.org/article/e463702430364d0c8eb00028ad9fa4e6
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Hepatocellular carcinoma (HCC), an aggressive malignancy with a dismal prognosis, poses a significant public health challenge. Recent research has highlighted the crucial role of lipid metabolism in HCC development, with enhanced lipid synth
Externí odkaz:
https://doaj.org/article/64ea9247b2f2407f92af95d24edf84da
Autor:
Janina Behrens, Ingke Braren, Michelle Y. Jaeckstein, Luka Lilie, Markus Heine, Finnja Sass, Judith Sommer, Dagmar Silbert-Wagner, Marceline M. Fuh, Anna Worthmann, Leon Straub, Tarek Moustafa, Joerg Heeren, Ludger Scheja
Publikováno v:
Molecular Metabolism, Vol 88, Iss , Pp 101999- (2024)
Objective: Recombinant adeno-associated virus (rAAV) vectors are powerful tools for the sustained expression of proteins in vivo and have been successfully used for mechanistic studies in mice. A major challenge associated with this method is to obta
Externí odkaz:
https://doaj.org/article/107161de55d9488bb70aeb07ce4f4045
Autor:
Liuchunyang Yu, Jinxiu Qian, Xiaoxia Xue, Mingshi Pang, Xiangpeng Wang, Xiaoyu Li, Meng Tian, Cheng Lu, Cheng Xiao, Yuanyan Liu
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 179, Iss , Pp 117432- (2024)
Hepatocellular carcinoma (HCC) remains the fourth leading cause of cancer-associated death globally with a lack of efficient therapy. The pathogenesis of HCC is a complex and multistep process, highly reliant on de novo lipogenesis, from which tumor
Externí odkaz:
https://doaj.org/article/1083baa6f6a64d32b41852bcf7473dca
Autor:
Amée M. Buziau, Maaike H. Oosterveer, Kristiaan Wouters, Trijnie Bos, Dean R. Tolan, Loranne Agius, Brian E. Ford, David Cassiman, Coen D.A. Stehouwer, Casper G. Schalkwijk, Martijn C.G.J. Brouwers
Publikováno v:
Molecular Metabolism, Vol 87, Iss , Pp 101984- (2024)
Objective: Stable isotope studies have shown that hepatic de novo lipogenesis (DNL) plays an important role in the pathogenesis of intrahepatic lipid (IHL) deposition. Furthermore, previous research has demonstrated that fructose 1-phosphate (F1P) no
Externí odkaz:
https://doaj.org/article/f788e7cbbd6b437a8180795a7483cdf6
Autor:
Yanmei Yuan, Junting Xu, Quanxin Jiang, Chuanxin Yang, Ning Wang, Xiaolong Liu, Hai-long Piao, Sijia Lu, Xianjing Zhang, Liu Han, Zhiyan Liu, Jiabin Cai, Fang Liu, Suzhen Chen, Junli Liu
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-21 (2024)
Abstract Background Targeting ferroptosis has been identified as a promising approach for the development of cancer therapies. Monounsaturated fatty acid (MUFA) is a type of lipid that plays a crucial role in inhibiting ferroptosis. Ficolin 3 (FCN3)
Externí odkaz:
https://doaj.org/article/a0fde06c913349df8656e2b1aeadc564
Publikováno v:
Journal of Advanced Biotechnology and Experimental Therapeutics, Vol 7, Iss 3, Pp 612-619 (2024)
Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver pathologies. Molecular mechanisms of NAFLD pathogenesis are complex and still require further clarification. Thus, this study aimed to investigate the impact of lipoic a
Externí odkaz:
https://doaj.org/article/cf72931b28e449989626491be4dc1e16
Autor:
Sonoko Karino, Haruki Usuda, Shoma Kanda, Takayuki Okamoto, Tomomi Niibayashi, Takahisa Yano, Kohji Naora, Koichiro Wada
Publikováno v:
Biochemistry and Biophysics Reports, Vol 40, Iss , Pp 101848- (2024)
This study investigated whether a standard calorie diet that is high in glucose and deficient in dietary fibre (described as HGD [high glucose diet]) induces hepatic fat accumulation in mice. We evaluated hepatic steatosis at 7 days and 14 days after
Externí odkaz:
https://doaj.org/article/40a0aedacf6349a4992ad120707ed221