Výsledky vyhledávání - "de novo enhancers"

Akademický článek

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Data from Identification of De Novo Enhancers Activated by TGFβ to Drive Expression of CDKN2A and B in HeLa Cells

Autor: Stephen X. Skapek, Yanbin Zheng, Priscilla Liem, Qinbo Zhou, Jing Liu, Jared C. Hooks, Lynda Bennett, Lin Xu, Yen-Ting Liu

Disruption of the CDKN2A (INK4A/ARF) and B (INK4B) genes, which encode three function-independent tumor suppressors, is one of the most common events in human cancer. Because their relative importance in tumor prevention appears to be species- and co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdacb882248483cb660a5ce1f2ea3454
https://doi.org/10.1158/1541-7786.c.6540370

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Supplementary Data and Methods from Identification of De Novo Enhancers Activated by TGFβ to Drive Expression of CDKN2A and B in HeLa Cells

Autor: Stephen X. Skapek, Yanbin Zheng, Priscilla Liem, Qinbo Zhou, Jing Liu, Jared C. Hooks, Lynda Bennett, Lin Xu, Yen-Ting Liu

Supplementary Table S1. Sequences of siRNAs, sgRNAs and primers for regular PCR, qRT-PCR and ChIP-qPCR Figure S1. Global analysis of ARF regulation from The Cancer Genome Atlas (TCGA). Figure S2. The status of DNA methylation at promoter regions of C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15abb094d51e6a185b5fbcd3ea41b526
https://doi.org/10.1158/1541-7786.22512907.v1

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Identification of De Novo Enhancers Activated by TGFβ to Drive Expression of CDKN2A and B in HeLa Cells

Autor: Jared C. Hooks, Yanbin Zheng, Yen Ting Liu, Jing Liu, Lin Xu, Priscilla Liem, Stephen X. Skapek, Lynda Bennett, Qinbo Zhou

Publikováno v: Molecular Cancer Research. 17:1854-1866

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::87df8aa8aa53c4222fce40caf955ddff
https://doi.org/10.1158/1541-7786.mcr-19-0289

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Akademický článek

Multi-Dimensional Gene Regulation in Innate and Adaptive Lymphocytes: A View From Regulomes

Autor: Nilisha Fernando, Giuseppe Sciumè, John J. O’Shea, Han-Yu Shih

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

The precise control of cytokine production by innate lymphoid cells (ILCs) and their T cell adaptive system counterparts is critical to mounting a proper host defense immune response without inducing collateral damage and autoimmunity. Unlike T cells

Externí odkaz: https://doaj.org/article/a384158720d147568e23778c7954183a

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Rapid enhancer remodeling and transcription factor repurposing enable high magnitude gene induction upon acute activation of NK cells

Autor: Hong-Wei Sun, Chen Yao, Fred P. Davis, Kiyoshi Hirahara, Tasha A. Morrison, Vittorio Sartorelli, Yuka Kanno, Beatrice Zitti, Yohei Mikami, Giuseppe Sciumè, Sadie Signorella, Stephen R. Brooks, Difeng Fang, Han-Yu Shih, Dragana Jankovic, Hiroyuki Nagashima, Alejandro V. Villarino, Shingo Nakayamada, John J. O'Shea

Publikováno v: Immunity

Summary Innate immune responses rely on rapid and precise gene regulation mediated by accessibility of regulatory regions to transcription factors (TFs). In natural killer (NK) cells and other innate lymphoid cells, competent enhancers are primed dur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ad1806cd35645a8c74d4aa2f748034d
https://europepmc.org/articles/PMC7572751/

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