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E2F1 and E2F2-Mediated Repression of CPT2 Establishes a Lipid-Rich Tumor-Promoting Environment.

Autor: González-Romero F; Department of Physiology, Faculty of Medicine and Nursing, University of Basque Country UPV/EHU, Leioa, Spain., Mestre D; Department of Physiology, Faculty of Medicine and Nursing, University of Basque Country UPV/EHU, Leioa, Spain.; BioCruces Bizkaia Health Research Institute, Cruces University Hospital, CIBERehd, Barakaldo, Spain., Aurrekoetxea I; Department of Physiology, Faculty of Medicine and Nursing, University of Basque Country UPV/EHU, Leioa, Spain.; BioCruces Bizkaia Health Research Institute, Cruces University Hospital, CIBERehd, Barakaldo, Spain., O'Rourke CJ; Department of Health and Medical Sciences, Biotech Research and Innovation Center, University of Copenhagen, Denmark., Andersen JB; Department of Health and Medical Sciences, Biotech Research and Innovation Center, University of Copenhagen, Denmark., Woodhoo A; Center for Cooperative Research in Bioscience (CIC bioGUNE), Derio, Spain.; Ikerbasque, Basque Foundation for Science, Bilbao, Spain., Tamayo-Caro M; Center for Cooperative Research in Bioscience (CIC bioGUNE), Derio, Spain., Varela-Rey M; Liver Disease Laboratory, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), CIBERehd Derio, Spain., Palomo-Irigoyen M; Center for Cooperative Research in Bioscience (CIC bioGUNE), Derio, Spain., Gómez-Santos B; Department of Physiology, Faculty of Medicine and Nursing, University of Basque Country UPV/EHU, Leioa, Spain., de Urturi DS; Department of Physiology, Faculty of Medicine and Nursing, University of Basque Country UPV/EHU, Leioa, Spain., Núñez-García M; Department of Physiology, Faculty of Medicine and Nursing, University of Basque Country UPV/EHU, Leioa, Spain., García-Rodríguez JL; Department of Physiology, Faculty of Medicine and Nursing, University of Basque Country UPV/EHU, Leioa, Spain., Fernández-Ares L; Department of Physiology, Faculty of Medicine and Nursing, University of Basque Country UPV/EHU, Leioa, Spain.; BioCruces Bizkaia Health Research Institute, Cruces University Hospital, CIBERehd, Barakaldo, Spain., Buqué X; Department of Physiology, Faculty of Medicine and Nursing, University of Basque Country UPV/EHU, Leioa, Spain.; BioCruces Bizkaia Health Research Institute, Cruces University Hospital, CIBERehd, Barakaldo, Spain., Iglesias-Ara A; Department of Genetic, Physical Anthropology and Animal Physiology, Faculty of Science and Technology, University of Basque Country UPV/EHU, Leioa, Spain., Bernales I; SGIKER, University of Basque Country UPV/EHU, Leioa, Spain., De Juan VG; Liver Disease Laboratory, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), CIBERehd Derio, Spain., Delgado TC; Liver Disease Laboratory, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), CIBERehd Derio, Spain., Goikoetxea-Usandizaga N; Liver Disease Laboratory, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), CIBERehd Derio, Spain., Lee R; Ionis Pharmaceuticals, Carlsbad, California., Bhanot S; Ionis Pharmaceuticals, Carlsbad, California., Delgado I; Department of Physiology, Faculty of Medicine and Nursing, University of Basque Country UPV/EHU, Leioa, Spain., Perugorria MJ; Department of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital, University of the Basque Country UPV/EHU, CIBERehd, San Sebastian, Spain.; Department of Medicine, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU, Leioa, Spain., Errazti G; BioCruces Bizkaia Health Research Institute, Cruces University Hospital, CIBERehd, Barakaldo, Spain., Mosteiro L; BioCruces Bizkaia Health Research Institute, Cruces University Hospital, CIBERehd, Barakaldo, Spain., Gaztambide S; BioCruces Bizkaia Health Research Institute, Cruces University Hospital, CIBERehd, Barakaldo, Spain.; Faculty of Medicine and Nursing, University of Basque Country UPV/EHU, CIBERDEM, CIBERER, Leioa, Spain., Martinez de la Piscina I; BioCruces Bizkaia Health Research Institute, Cruces University Hospital, CIBERehd, Barakaldo, Spain., Iruzubieta P; Department of Gastroenterology and Hepatology, Marqués de Valdecilla University Hospital, Santander, Spain., Crespo J; Department of Gastroenterology and Hepatology, Marqués de Valdecilla University Hospital, Santander, Spain., Banales JM; Ikerbasque, Basque Foundation for Science, Bilbao, Spain.; Department of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital, University of the Basque Country UPV/EHU, CIBERehd, San Sebastian, Spain., Martínez-Chantar ML; Liver Disease Laboratory, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), CIBERehd Derio, Spain., Castaño L; BioCruces Bizkaia Health Research Institute, Cruces University Hospital, CIBERehd, Barakaldo, Spain.; Faculty of Medicine and Nursing, University of Basque Country UPV/EHU, CIBERDEM, CIBERER, Leioa, Spain., Zubiaga AM; Department of Genetic, Physical Anthropology and Animal Physiology, Faculty of Science and Technology, University of Basque Country UPV/EHU, Leioa, Spain., Aspichueta P; Department of Physiology, Faculty of Medicine and Nursing, University of Basque Country UPV/EHU, Leioa, Spain. patricia.aspichueta@ehu.eus.; BioCruces Bizkaia Health Research Institute, Cruces University Hospital, CIBERehd, Barakaldo, Spain.

Publikováno v: Cancer research [Cancer Res] 2021 Jun 01; Vol. 81 (11), pp. 2874-2887. Date of Electronic Publication: 2021 Mar 26.