Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity.

Autor: Uitdehaag JCM; Netherlands Translational Research Center B.V., Kloosterstraat 9, 5349AB Oss, The Netherlands., de Man J; Netherlands Translational Research Center B.V., Kloosterstraat 9, 5349AB Oss, The Netherlands., Willemsen-Seegers N; Netherlands Translational Research Center B.V., Kloosterstraat 9, 5349AB Oss, The Netherlands., Prinsen MBW; Netherlands Translational Research Center B.V., Kloosterstraat 9, 5349AB Oss, The Netherlands., Libouban MAA; Netherlands Translational Research Center B.V., Kloosterstraat 9, 5349AB Oss, The Netherlands., Sterrenburg JG; Netherlands Translational Research Center B.V., Kloosterstraat 9, 5349AB Oss, The Netherlands., de Wit JJP; Netherlands Translational Research Center B.V., Kloosterstraat 9, 5349AB Oss, The Netherlands., de Vetter JRF; Netherlands Translational Research Center B.V., Kloosterstraat 9, 5349AB Oss, The Netherlands., de Roos JADM; Netherlands Translational Research Center B.V., Kloosterstraat 9, 5349AB Oss, The Netherlands., Buijsman RC; Netherlands Translational Research Center B.V., Kloosterstraat 9, 5349AB Oss, The Netherlands., Zaman GJR; Netherlands Translational Research Center B.V., Kloosterstraat 9, 5349AB Oss, The Netherlands. Electronic address: guido.zaman@ntrc.nl.

Publikováno v: Journal of molecular biology [J Mol Biol] 2017 Jul 07; Vol. 429 (14), pp. 2211-2230. Date of Electronic Publication: 2017 May 21.